Alcohol and HIV: Biobehavioral Interactions and Interventions

酒精和艾滋病毒：生物行为相互作用和干预措施

• 批准号: 9493323
• 负责人: PETER M. MONTI
• 金额: $ 123.16万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9493323
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adult; Alabama; Alcohol consumption; Alcohols; Area; Behavior Therapy; Behavioral; Behavioral Mechanisms; Behavioral Research; Biological; Biostatistics Core; Boston; Brain; California; Caring; Ceramides; Clinic; Clinical; Collaborations; Complement; Complex; Cytokine Activation; Decision Making; Enhancement Technology; Epidemic; Florida; Funding; Gap Junctions; Genetic Markers; HIV; HIV Infections; Health; Heavy Drinking; Hepatic; Hepatitis; Hospitals; Human; Human immunodeficiency virus test; Impaired cognition; Individual; Infection; Institution; Insulin Resistance; Interdisciplinary Study; International; Intervention; Investigation; Laboratories; Link; Liver Dysfunction; Longevity; Measures; Medical center; Methods; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Neurocognitive; Neurocognitive Deficit; Outcome; Outcomes Research; Pathway interactions; Patients; Pilot Projects; Postdoctoral Fellow; Public Health; Public Health Schools; Research; Research Activity; Research Personnel; Research Priority; Resources; Role; Science; Sex Behavior; Structure; Tablets; Technology; Training Support; U-Series Cooperative Agreements; Universities; Work; alcohol effect; alcohol intervention; alcohol research; alcohol risk; alcohol use disorder; antiretroviral therapy; base; behavior change; biobehavior; co-infection; high risk men; high risk sexual behavior; imaging approach; immune function; improved; innovation; interdisciplinary approach; liver function; medical schools; men who have sex with men; minority health; mortality; multidisciplinary; neuroimaging; neuroimaging marker; post-doctoral training; prevent; programs; public health relevance; reduced alcohol use; sex risk; sexual minority; therapy adherence; translational approach; transmission process; viral transmission; virology; white matter

 DESCRIPTION (provided by applicant): Alcohol use contributes to morbidity and mortality associated with HIV by (a) reducing antiretroviral therapy adherence, (b) worsening virologic outcomes and immune functioning, (c) exacerbating liver dysfunction, and (d) exacerbating neurocognitive deficits associated with HIV. In addition, alcohol use among both HIV-infected and uninfected individuals is implicated in high-risk sexual behavior that leads to HIV transmission. The Brown University Alcohol Research Center on HIV (ARCH) was funded by NIAAA in 2010 to conduct integrated interdisciplinary research on alcohol and HIV that can inform clinical approaches to caring for people living with HIV and efforts to prevent HIV transmission, as well as to serve as a regional and national resource for collaborative research on alcohol and HIV interactions. Through collaborations with the Lifespan/Tufts/Brown Center for AIDS Research and local hospitals, Fenway Health, UMass-Boston, Columbia University, University of Florida, and UCSD, we have been conducting state-of-the-art research on the combined effects of alcohol and HIV on brain structure and function and on the effects of behavioral alcohol intervention on alcohol use, sexual risk behavior, virologic outcomes, liver function, and neurocognitive function in HIV-infected men who have sex with men. The addition of two Resource Cores (U24AA022000; U24AA022003) to the ARCH have further broadened this collaborative research with a particular emphasis on two strengths at Brown, sexual minority health and mechanisms of behavior change; these cooperative agreements with NIAAA involve collaborations with Yale University, Harvard, University of Pittsburgh, University of Alabama-Birmingham, and Johns Hopkins University. This renewal application seeks to build on the progress made through the Brown ARCH expanding the scope of our research around our tightly integrated core themes. The ARCH is comprised of an Administrative Core (which also handles postdoctoral training and pilots), three Research Components, and Virology and Biostatistics Cores. Research activities address overlapping hypotheses regarding key variables (alcohol use, virology, hepatic function, neurocognitive function, and high-risk sexual behavior) and interrelationships among these variables using diverse methods including neuroimaging, biomarker analysis, behavioral interventions, technology-assisted interventions, and human laboratory-based behavioral research. These activities provide an integrated body of innovative alcohol-HIV research that can yield far greater total public health impact than any or all of them could if conducted independently. Further, the ARCH serves as a nexus for integration of alcohol-HIV science across proposed components, pilot projects, and complementary studies within Brown including investigators from all four departments in the Brown University School of Public Health and four additional departments in the Medical School. Finally, the ARCH serves as a bridge between the deep pool of investigators at Brown focusing on alcohol and HIV and investigators at the other NIAAA-funded Consortiums for HIV/AIDS and Alcohol-Related Outcomes Research.

 描述（由适用提供）：通过（a）降低抗逆转录病毒疗法的依从性，（b）令人担忧的病毒学结果和免疫功能，（c）加剧肝功能障碍，以及（d）与HIV相关的恶性症状。此外，感染HIV和未感染的个体中的酒精使用在导致HIV传播的高风险性行为中隐含。 Brown University艾滋病毒（ARCH）的棕色大学酒精研究中心于2010年由NIAAA资助，以对酒精和艾滋病毒进行综合的跨学科研究，这些研究可以告知人们照顾患有艾滋病毒的人的临床方法，并努力预防艾滋病毒传播，并作为对酒精和艾滋病毒互动的区域和国家资源。 Through collaborations with the Lifespan/Tufts/Brown Center for AIDS Research and local hospitals, Fenway Health, UMass-Boston, Columbia University, University of Florida, and UCSD, we have been conducting state-of-the-art research on the combined effects of alcohol and HIV on brain structure and function and on the effects of behavioral alcohol intervention on alcohol use, sexual risk behavior, virologic outcomes, liver function, and neurocognitive function in与男人发生性关系的艾滋病毒感染者。将两个资源核心（U24AA022000； U24AA022003）添加到拱门中，进一步扩大了这项合作研究，特别着重于棕色的两种优势，性少数派健康和行为改变机制；这些与NIAAA的合作协议涉及与耶鲁大学，哈佛大学，匹兹堡大学，阿拉巴马大学 - 伯明翰大学和约翰·霍普金斯大学的合作。该更新应用程序旨在基于通过棕色拱门取得的进展，扩大了我们围绕我们紧密整合的核心主题的研究范围。拱门由行政核心（还处理博士后培训和飞行员），三个研究组成部分以及病毒学和生物统计学核心组成。研究活动涉及有关关键变量的重叠假设（酒精使用，病毒学，肝功能，神经认知功能和高风险的性行为）以及这些变量之间使用神经影像学方法，包括神经影像学，生物标志物分析，行为干预，技术认可的干预措施以及人类实验室的行为研究，以及这些变量之间的相互关系。这些活动提供了一系列创新的饮酒研究综合体系，该研究可以产生比独立进行的任何或全部的公共卫生影响更大。此外，该拱门是跨拟议的组件，试点项目和互补研究的酒精-HIV科学整合的联系，包括布朗大学公共卫生学院所有四个部门的研究人员以及医学院的其他四个部门。最后，拱门是布朗的研究人员之间的桥梁，重点是酒精和艾滋病毒，以及其他NIAAA资助的财团，用于HIV/AIDS和与酒精有关的结果研究。