Alcohol and HIV: Biobehavioral Interactions and Interventions

酒精和艾滋病毒：生物行为相互作用和干预措施

• 批准号: 9493323
• 负责人: PETER M. MONTI
• 金额: $ 123.16万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9493323
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adult; Alabama; Alcohol consumption; Alcohols; Area; Behavior Therapy; Behavioral; Behavioral Mechanisms; Behavioral Research; Biological; Biostatistics Core; Boston; Brain; California; Caring; Ceramides; Clinic; Clinical; Collaborations; Complement; Complex; Cytokine Activation; Decision Making; Enhancement Technology; Epidemic; Florida; Funding; Gap Junctions; Genetic Markers; HIV; HIV Infections; Health; Heavy Drinking; Hepatic; Hepatitis; Hospitals; Human; Human immunodeficiency virus test; Impaired cognition; Individual; Infection; Institution; Insulin Resistance; Interdisciplinary Study; International; Intervention; Investigation; Laboratories; Link; Liver Dysfunction; Longevity; Measures; Medical center; Methods; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Neurocognitive; Neurocognitive Deficit; Outcome; Outcomes Research; Pathway interactions; Patients; Pilot Projects; Postdoctoral Fellow; Public Health; Public Health Schools; Research; Research Activity; Research Personnel; Research Priority; Resources; Role; Science; Sex Behavior; Structure; Tablets; Technology; Training Support; U-Series Cooperative Agreements; Universities; Work; alcohol effect; alcohol intervention; alcohol research; alcohol risk; alcohol use disorder; antiretroviral therapy; base; behavior change; biobehavior; co-infection; high risk men; high risk sexual behavior; imaging approach; immune function; improved; innovation; interdisciplinary approach; liver function; medical schools; men who have sex with men; minority health; mortality; multidisciplinary; neuroimaging; neuroimaging marker; post-doctoral training; prevent; programs; public health relevance; reduced alcohol use; sex risk; sexual minority; therapy adherence; translational approach; transmission process; viral transmission; virology; white matter

 DESCRIPTION (provided by applicant): Alcohol use contributes to morbidity and mortality associated with HIV by (a) reducing antiretroviral therapy adherence, (b) worsening virologic outcomes and immune functioning, (c) exacerbating liver dysfunction, and (d) exacerbating neurocognitive deficits associated with HIV. In addition, alcohol use among both HIV-infected and uninfected individuals is implicated in high-risk sexual behavior that leads to HIV transmission. The Brown University Alcohol Research Center on HIV (ARCH) was funded by NIAAA in 2010 to conduct integrated interdisciplinary research on alcohol and HIV that can inform clinical approaches to caring for people living with HIV and efforts to prevent HIV transmission, as well as to serve as a regional and national resource for collaborative research on alcohol and HIV interactions. Through collaborations with the Lifespan/Tufts/Brown Center for AIDS Research and local hospitals, Fenway Health, UMass-Boston, Columbia University, University of Florida, and UCSD, we have been conducting state-of-the-art research on the combined effects of alcohol and HIV on brain structure and function and on the effects of behavioral alcohol intervention on alcohol use, sexual risk behavior, virologic outcomes, liver function, and neurocognitive function in HIV-infected men who have sex with men. The addition of two Resource Cores (U24AA022000; U24AA022003) to the ARCH have further broadened this collaborative research with a particular emphasis on two strengths at Brown, sexual minority health and mechanisms of behavior change; these cooperative agreements with NIAAA involve collaborations with Yale University, Harvard, University of Pittsburgh, University of Alabama-Birmingham, and Johns Hopkins University. This renewal application seeks to build on the progress made through the Brown ARCH expanding the scope of our research around our tightly integrated core themes. The ARCH is comprised of an Administrative Core (which also handles postdoctoral training and pilots), three Research Components, and Virology and Biostatistics Cores. Research activities address overlapping hypotheses regarding key variables (alcohol use, virology, hepatic function, neurocognitive function, and high-risk sexual behavior) and interrelationships among these variables using diverse methods including neuroimaging, biomarker analysis, behavioral interventions, technology-assisted interventions, and human laboratory-based behavioral research. These activities provide an integrated body of innovative alcohol-HIV research that can yield far greater total public health impact than any or all of them could if conducted independently. Further, the ARCH serves as a nexus for integration of alcohol-HIV science across proposed components, pilot projects, and complementary studies within Brown including investigators from all four departments in the Brown University School of Public Health and four additional departments in the Medical School. Finally, the ARCH serves as a bridge between the deep pool of investigators at Brown focusing on alcohol and HIV and investigators at the other NIAAA-funded Consortiums for HIV/AIDS and Alcohol-Related Outcomes Research.

 说明(申请人提供)：酒精使用通过以下方式导致与艾滋病毒有关的发病率和死亡率：(A)减少抗逆转录病毒治疗的依从性，(B)恶化病毒学结果和免疫功能，(C)加剧肝功能障碍，以及(D)加剧与艾滋病毒有关的神经认知缺陷。此外，无论是艾滋病毒感染者还是非感染者，饮酒都与导致艾滋病毒传播的高危性行为有关。布朗大学艾滋病毒酒精研究中心(ARCH)于2010年由NIAAA资助，开展关于酒精和艾滋病毒的跨学科综合研究，可为护理艾滋病毒携带者和预防艾滋病毒传播的临床方法提供信息，并作为关于酒精和艾滋病毒相互作用的区域和国家合作研究的资源。通过与生命周期/塔夫茨/布朗艾滋病研究中心和当地医院、芬威健康、马萨诸塞州大学波士顿分校、哥伦比亚大学、佛罗里达大学和加州大学圣地亚哥分校的合作，我们一直在进行最先进的研究，研究酒精和艾滋病毒对大脑结构和功能的联合影响，以及行为酒精干预对酒精使用、性风险行为、病毒学结果、肝功能和神经认知功能的影响。ARCH增加了两个资源核心(U24AA022000和U24AA022003)，进一步扩大了这项合作研究的范围，特别强调了布朗大学的两个优势，性少数群体健康和行为改变机制；这些与NIAAA的合作协议涉及与耶鲁大学、哈佛大学、匹兹堡大学、阿拉巴马大学伯明翰分校和约翰·霍普金斯大学的合作。这项续签申请寻求在通过布朗拱门取得的进展的基础上，围绕我们紧密结合的核心主题扩大我们的研究范围。ARCH由一个管理核心(还负责博士后培训和试点)、三个研究部分以及病毒学和生物统计学核心组成。研究活动使用不同的方法，包括神经成像、生物标记物分析、行为干预、技术辅助干预和基于实验室的行为研究，解决了关于关键变量(酒精使用、病毒学、肝功能、神经认知功能和高危性行为)以及这些变量之间的相互关系的重叠假设。这些活动提供了一个创新的酒精-艾滋病毒研究的综合机构，可以产生比任何一个或全部单独进行的更大的总体公共卫生影响。此外，该拱门是整合酒精-艾滋病毒科学的纽带，涉及布朗大学公共卫生学院所有四个系和医学院另外四个系的拟议组成部分、试点项目和补充研究。最后，这座拱门是布朗大学专注于酒精和艾滋病毒的深层调查人员与其他NIAAA资助的艾滋病毒/艾滋病和酒精相关结果研究财团的调查人员之间的桥梁。