Advancing a Bio-Psycho-Social Alcohol Treatment Research and Mentoring Program

描述（由申请人提供）：这是一份新的高级研究和导师奖（K05）申请。候选人Peter M. Monti是布朗大学酒精与成瘾研究中心的杰出教授、酒精与成瘾研究中心主任和行为与社会科学部主任，他建议对布朗大学中心的四位杰出科学家进行初步的密集研究指导，并将他的研究项目转向青年和年轻人。因此，Monti博士建议将VA高级职业科学家奖改为K05奖。学员和师徒计划。其中一名被提议的学员，唐·奥普拉里奥（社会心理学家）最近从牛津大学（Oxford University）招聘，并获得了终身教职。另外两名被推荐的教员指导者，罗伯特·米兰达（临床心理学家）和塔拉·怀特（神经科学家）正在“研究”的轨道上。虽然这三个人都有出色的发表记录，但只有米兰达发表过酒精论文，并获得了NIAAA的资助（1个K23和2个r21）。Operario和White是nida资助的。虽然他们三人都对成为酒精研究人员表现出了浓厚的兴趣，但他们都没有得到NIAAA的R01级别的资助。米兰达走得最远，尽管Operario和White都提交了酒精申请，作为候选人未决的P60中心拨款提案的一部分。第四个学员，玛吉·斯基（社会流行病学家）是与蒙蒂一起工作的博士后候选人。她也有很好的出版记录。然而，她刚刚发表了她的第一本关于酒精的手稿，尽管她表示对酒精感兴趣，因为这是她来布朗大学的原因。对所有申请者的指导目标包括提供有针对性的和一般性的指导和支持，包括资助，酒精研究项目的发展，以及更一般的专业发展问题，包括如何指导他们自己的学员的反馈。重要的是，所有四名学员都已被纳入申请人的研究方案，该方案正朝着青年酒精干预和酒精/艾滋病毒相互作用研究的方向发展。申请人打算在该领域以及神经科学和MRI模式中获得互补的专业知识-他的P60的所有主题。关于研究计划，申请人打算继续专注于广泛的研究议程，但重点是治疗机制，药物治疗，环境因素和个体差异。利用他现有的数据集，他建议在他短暂的干预工作的背景下，研究治疗结果的中介和调节因子，以及对日常饮酒行为的评估。此外，他将在正在进行的托吡酯对重度饮酒者的影响试验中增加一项基于实验室的酒精影响研究，从而使托吡酯和饮酒的影响研究既可以在实验室中进行（新数据有待收集），也可以在自然环境中进行（通过已经收集的生态瞬间评估数据，作为他正在进行的R01的一部分）。最后，随着他未决的P60申请的资金变得更加清晰，他将开始对这个项目的各个方面进行相关的试点工作。

DESCRIPTION (provided by applicant): This is a new application for a Senior Research and Mentorship Award (K05). The candidate, Peter M. Monti, Distinguished Professor of Alcohol and Addiction Studies, Director, Center for Alcohol and Addiction Studies and Head of the Behavioral and Social Sciences Section at Brown University, proposes an initial period of intense research mentoring to four outstanding Brown University scientists in his Center and a shift in his research program to youth and young adults. Therefore, Dr. Monti proposes to transition from a VA Senior Career Scientist Award to the K05. Mentees and Mentoring Plan. One of the proposed mentees, Don Operario (a social psychologist) was recently recruited from Oxford University and is in a tenure-track position. The other two proposed faculty mentees, Robert Miranda (a clinical psychologist) and Tara White (a neuroscientist) are on a "research" track. While all three have excellent publication records, only Miranda has published alcohol papers and has received funding from NIAAA (a K23 and 2 R21s). Operario and White are NIDA-funded. None have been funded at the R01 level from NIAAA, though all three have demonstrated strong interest in becoming alcohol researchers. Miranda is furthest along, though both Operario and White have submitted alcohol applications as part of the candidate's pending P60 Center Grant Proposal. The fourth mentee, Margie Skeer (a social epidemiologist) is a postdoctoral candidate working with Monti. She too has a strong publication record. However, she has only just published her first alcohol manuscript, though she has indicated interest in alcohol, as this was her reason for coming to Brown. Mentoring goals for all applicants involve providing both targeted and general guidance and support for grantsmanship, the development of alcohol research programs, and more general professional development issues including feedback on how to mentor their own trainees. Importantly, all four mentees have been incorporated into the applicant's research program which is moving in the direction of youth alcohol intervention and the study of alcohol/HIV interactions. The applicant intends to gain complementary expertise in this area as well as in neuroscience and MRI modalities - all topics of his P60. With respect to the Research Plan, the applicant intends to continue to focus on a research agenda that is broad and yet focused on treatment mechanisms, pharmacotherapy, contextual factors and individual differences. Using his existing data sets he proposes to study mediators and moderators of treatment outcomes and the assessment of daily drinking behavior in the context of his brief intervention work. In addition he will add a study of lab-based alcohol effects onto his ongoing trial of topiramate for heavy drinkers, thus enabling the study of the effects of topiramate and drinking both in the lab (new data to be collected) and in the natural environment (through Ecological Momentary Assessment data that are already collected as part of his ongoing R01). Finally, as funding for his pending P60 application becomes clearer, he will begin pertinent pilot work on aspects of this project. PUBLIC HEALTH RELEVANCE: Advancing biopsychosocial approaches to alcohol treatment and mentoring has the potential to influence public health by reducing alcohol use in youth through improved early intervention and treatment. More and better mentored alcohol treatment scientists will facilitate the goal of reduced use in youth.