Advancing a Bio-Psycho-Social Alcohol Treatment Research and Mentoring Program

描述(由申请人提供)：这是一份新的高级研究和导师奖的申请(K05)。候选人彼得·M·蒙蒂是著名的酒精和成瘾研究教授、酒精和成瘾研究中心主任、布朗大学行为和社会科学部门负责人，他提议在他的中心为四名杰出的布朗大学科学家提供初期的密集研究指导，并将他的研究项目转向年轻人。因此，蒙蒂博士建议从退伍军人管理局高级职业科学家奖过渡到K05奖。指导对象和指导计划。Don Operario(社会心理学家)是被提名的学员之一，他最近从牛津大学招聘，目前处于终身教职轨道上。另外两名被提名的教员导师罗伯特·米兰达(临床心理学家)和塔拉·怀特(神经学家)正在进行“研究”。虽然这三家公司都有出色的出版记录，但只有米兰达发表过酒精论文，并获得了NIAAA的资助(K23和2辆R21)。Operario和White是由NIDA资助的。没有一个是从NIAAA获得的R01水平的资金，尽管这三个人都表现出了成为酒精研究人员的强烈兴趣。米兰达走得最远，尽管操作员和怀特都提交了酒精申请，作为候选人悬而未决的P60中心拨款提案的一部分。第四位导师Margie Skeer(社会流行病学家)是蒙蒂的博士后候选人。她也有很好的出版记录。然而，她刚刚出版了她的第一份酒精手稿，尽管她已经表示对酒精感兴趣，因为这是她来布朗的原因。为所有申请者提供有针对性和一般性的指导和支持，包括酒精研究项目的开发，以及更一般的职业发展问题，包括如何指导自己的学员的反馈。重要的是，所有四名被辅导者都被纳入了申请者的研究计划，该计划正朝着青少年酒精干预和酒精/艾滋病毒相互作用的研究方向发展。申请人打算在这一领域以及在神经科学和核磁共振成像方面获得补充专业知识--所有这些都是他的P60主题。关于研究计划，申请者打算继续侧重于一项广泛的研究议程，但重点是治疗机制、药物治疗、背景因素和个体差异。利用他现有的数据集，他建议在他的短暂干预工作的背景下，研究治疗结果的调解人和调解人，以及对日常饮酒行为的评估。此外，他还将在他正在进行的针对重度饮酒者的托吡酯试验中增加一项基于实验室的酒精影响研究，从而能够在实验室(将收集新数据)和在自然环境中(通过作为他正在进行的R01的一部分已经收集的生态瞬时评估数据)研究托吡酯和饮酒的影响。最后，随着他悬而未决的P60申请的资金变得更加明确，他将开始这个项目各方面的相关试点工作。 公共卫生相关性：通过改进早期干预和治疗，提高酒精治疗和辅导的生物、心理和社会方法，通过减少青少年的酒精使用，有可能影响公共健康。更多和更好地指导酒精治疗的科学家将有助于实现减少年轻人使用酒精的目标。

DESCRIPTION (provided by applicant): This is a new application for a Senior Research and Mentorship Award (K05). The candidate, Peter M. Monti, Distinguished Professor of Alcohol and Addiction Studies, Director, Center for Alcohol and Addiction Studies and Head of the Behavioral and Social Sciences Section at Brown University, proposes an initial period of intense research mentoring to four outstanding Brown University scientists in his Center and a shift in his research program to youth and young adults. Therefore, Dr. Monti proposes to transition from a VA Senior Career Scientist Award to the K05. Mentees and Mentoring Plan. One of the proposed mentees, Don Operario (a social psychologist) was recently recruited from Oxford University and is in a tenure-track position. The other two proposed faculty mentees, Robert Miranda (a clinical psychologist) and Tara White (a neuroscientist) are on a "research" track. While all three have excellent publication records, only Miranda has published alcohol papers and has received funding from NIAAA (a K23 and 2 R21s). Operario and White are NIDA-funded. None have been funded at the R01 level from NIAAA, though all three have demonstrated strong interest in becoming alcohol researchers. Miranda is furthest along, though both Operario and White have submitted alcohol applications as part of the candidate's pending P60 Center Grant Proposal. The fourth mentee, Margie Skeer (a social epidemiologist) is a postdoctoral candidate working with Monti. She too has a strong publication record. However, she has only just published her first alcohol manuscript, though she has indicated interest in alcohol, as this was her reason for coming to Brown. Mentoring goals for all applicants involve providing both targeted and general guidance and support for grantsmanship, the development of alcohol research programs, and more general professional development issues including feedback on how to mentor their own trainees. Importantly, all four mentees have been incorporated into the applicant's research program which is moving in the direction of youth alcohol intervention and the study of alcohol/HIV interactions. The applicant intends to gain complementary expertise in this area as well as in neuroscience and MRI modalities - all topics of his P60. With respect to the Research Plan, the applicant intends to continue to focus on a research agenda that is broad and yet focused on treatment mechanisms, pharmacotherapy, contextual factors and individual differences. Using his existing data sets he proposes to study mediators and moderators of treatment outcomes and the assessment of daily drinking behavior in the context of his brief intervention work. In addition he will add a study of lab-based alcohol effects onto his ongoing trial of topiramate for heavy drinkers, thus enabling the study of the effects of topiramate and drinking both in the lab (new data to be collected) and in the natural environment (through Ecological Momentary Assessment data that are already collected as part of his ongoing R01). Finally, as funding for his pending P60 application becomes clearer, he will begin pertinent pilot work on aspects of this project. PUBLIC HEALTH RELEVANCE: Advancing biopsychosocial approaches to alcohol treatment and mentoring has the potential to influence public health by reducing alcohol use in youth through improved early intervention and treatment. More and better mentored alcohol treatment scientists will facilitate the goal of reduced use in youth.