Advancing a Bio-Psycho-Social Alcohol Treatment Research and Mentoring Program

描述（由申请人提供）：这是一个高级研究和导师奖（K 05）的新申请。候选人彼得·M。蒙蒂，酒精和成瘾研究的杰出教授，主任，酒精和成瘾研究中心和行为和社会科学科在布朗大学的负责人，提出了一个密集的研究指导的初始阶段，四个杰出的布朗大学的科学家在他的中心和他的研究计划，以青年和年轻人的转变。因此，蒙蒂博士建议从VA高级职业科学家奖过渡到K 05。指导者和指导计划。其中一位被提议的学员Don Operario（社会心理学家）最近从牛津大学招聘，并处于终身职位。另外两名被推荐的教师学员，罗伯特米兰达（临床心理学家）和塔拉白色（神经科学家）正在“研究”轨道上。虽然这三个人都有很好的出版记录，但只有米兰达发表了关于酒精的论文，并获得了NIAAA的资助（一个K23和两个R21）。Operario和白色是NIDA资助的。没有一个获得NIAAA的R 01级资助，尽管这三个研究所都表现出了对成为酒精研究人员的浓厚兴趣。米兰达是最远的沿着，虽然两个操作和白色都提交了酒精申请的一部分，候选人的悬而未决的P60中心赠款提案。第四位学员，玛吉·斯凯尔（社会流行病学家）是蒙蒂的博士后候选人。她也有很好的出版记录。然而，她才刚刚发表了她的第一个酒精手稿，虽然她表示对酒精感兴趣，因为这是她来布朗的原因。所有申请人的指导目标包括为研究人员提供有针对性的和一般性的指导和支持，酒精研究计划的发展，以及更一般的专业发展问题，包括如何指导自己的学员的反馈。重要的是，所有四名学员都已被纳入申请人的研究方案，该方案正朝着青少年酒精干预和酒精/艾滋病毒相互作用研究的方向发展。申请人打算获得该领域以及神经科学和MRI模式的补充专业知识-他的P60的所有主题。关于研究计划，申请人打算继续专注于广泛的研究议程，但重点是治疗机制，药物治疗，背景因素和个体差异。利用他现有的数据集，他建议研究调解人和调解人的治疗结果和评估的日常饮酒行为的背景下，他的简短的干预工作。此外，他将在他正在进行的托吡酯对重度饮酒者的试验中增加一项基于实验室的酒精效应研究，从而能够在实验室（收集新数据）和自然环境中（通过已经收集的生态瞬时评估数据作为他正在进行的R 01的一部分）研究托吡酯和饮酒的影响。最后，随着他悬而未决的P60申请的资金变得更加明确，他将开始有关该项目各个方面的试点工作。 公共卫生相关性：通过改进早期干预和治疗减少青年人的酒精使用，推进酒精治疗和指导的生物心理社会方法有可能影响公共卫生。更多和更好地指导酒精治疗科学家将促进减少青年使用的目标。

DESCRIPTION (provided by applicant): This is a new application for a Senior Research and Mentorship Award (K05). The candidate, Peter M. Monti, Distinguished Professor of Alcohol and Addiction Studies, Director, Center for Alcohol and Addiction Studies and Head of the Behavioral and Social Sciences Section at Brown University, proposes an initial period of intense research mentoring to four outstanding Brown University scientists in his Center and a shift in his research program to youth and young adults. Therefore, Dr. Monti proposes to transition from a VA Senior Career Scientist Award to the K05. Mentees and Mentoring Plan. One of the proposed mentees, Don Operario (a social psychologist) was recently recruited from Oxford University and is in a tenure-track position. The other two proposed faculty mentees, Robert Miranda (a clinical psychologist) and Tara White (a neuroscientist) are on a "research" track. While all three have excellent publication records, only Miranda has published alcohol papers and has received funding from NIAAA (a K23 and 2 R21s). Operario and White are NIDA-funded. None have been funded at the R01 level from NIAAA, though all three have demonstrated strong interest in becoming alcohol researchers. Miranda is furthest along, though both Operario and White have submitted alcohol applications as part of the candidate's pending P60 Center Grant Proposal. The fourth mentee, Margie Skeer (a social epidemiologist) is a postdoctoral candidate working with Monti. She too has a strong publication record. However, she has only just published her first alcohol manuscript, though she has indicated interest in alcohol, as this was her reason for coming to Brown. Mentoring goals for all applicants involve providing both targeted and general guidance and support for grantsmanship, the development of alcohol research programs, and more general professional development issues including feedback on how to mentor their own trainees. Importantly, all four mentees have been incorporated into the applicant's research program which is moving in the direction of youth alcohol intervention and the study of alcohol/HIV interactions. The applicant intends to gain complementary expertise in this area as well as in neuroscience and MRI modalities - all topics of his P60. With respect to the Research Plan, the applicant intends to continue to focus on a research agenda that is broad and yet focused on treatment mechanisms, pharmacotherapy, contextual factors and individual differences. Using his existing data sets he proposes to study mediators and moderators of treatment outcomes and the assessment of daily drinking behavior in the context of his brief intervention work. In addition he will add a study of lab-based alcohol effects onto his ongoing trial of topiramate for heavy drinkers, thus enabling the study of the effects of topiramate and drinking both in the lab (new data to be collected) and in the natural environment (through Ecological Momentary Assessment data that are already collected as part of his ongoing R01). Finally, as funding for his pending P60 application becomes clearer, he will begin pertinent pilot work on aspects of this project. PUBLIC HEALTH RELEVANCE: Advancing biopsychosocial approaches to alcohol treatment and mentoring has the potential to influence public health by reducing alcohol use in youth through improved early intervention and treatment. More and better mentored alcohol treatment scientists will facilitate the goal of reduced use in youth.