AHRQ Mentored Clinical Scientist Research Career Development Award (K08): Maya Dewan

AHRQ 指导临床科学家研究职业发展奖 (K08)：Maya Dewan

• 批准号: 10374768
• 负责人: Maya L Dewan
• 金额: $ 14.99万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10374768
• 关键词: AHRQ; Mentored; Clinical; Scientist; Research

PROJECT ABSTRACT Pediatric in-hospital cardiac arrest most commonly occurs in the pediatric intensive care unit and carries extensive morbidity and mortality. This proposal describes a 5-year research and training program that will allow Dr. Maya Dewan to address the prevention of pediatric cardiac arrest through clinical decision support and implementation science. Having completed fellowship training in pediatric critical care medicine and building on a background of improvement science, epidemiology/biostatistics, and clinical informatics the applicant seeks to develop new knowledge and skills to use design informed clinical decision support and implementation science to improve the care and outcomes for critically ill children. This application seeks to address prevention of pediatric cardiac arrest. Prevention of cardiac arrest events is feasible because children often display warning signs prior to deterioration. The applicant’s preliminary studies demonstrate that prediction of pediatric patients at high-risk for clinical deterioration is feasible. The specific aims of the proposed investigations are to: 1) To prospectively validate the PICU Warning Tool to predict clinical deterioration, 2) To evaluate the impact on prediction and situational awareness of adding manual high- risk criteria to the automated PICU Warning Tool, 3) To elucidate factors in system design that will improve implementation of the PICU Warning Tool. This work is significant as it focuses on the development and implementation of an effective health information technology intervention to improve health care quality. It leverages the capability of health information technology to improve quality, efficiency, and effectiveness of care for the highest risk pediatric patients. While this training grant focuses on the implementation of health IT in improvement science work, it also addresses the research areas of design, use, and impact on outcomes. Through a Type 1 effectiveness-implementation hybrid design, Dr. Dewan will identify barriers and facilitators to implementation to facilitate a successful translation from an academic research tool to a well implemented clinical decision support tool suitable for routine practice.

项目摘要 儿科内心脏骤停最常见发生在小儿重症监护病房中，并携带 广泛的发病率和死亡率。该建议描述了一项为期5年的研究和培训计划 允许Maya Dewan博士通过临床决策支持解决儿科心脏骤停 和实施科学。完成了小儿重症监护医学的研究金培训和 建立在改进科学，流行病学/生物统计学和临床​​信息的背景下 申请人试图开发新的知识和技能，以使用设计知识的临床决策支持和 实施科学，以改善重症儿童的护理和成果。 该申请旨在解决预防儿科心脏骤停。预防心脏骤停事件是 可行，因为孩子在确定之前经常显示警告标志。申请人的初步研究 证明在高危临床定义时对小儿患者的预测是可行的。具体 拟议调查的目的是：1）前瞻性验证PICU警告工具以预测 临床确定，2）评估对预测和情境意识的影响 自动PICU警告工具的风险标准，3）阐明系统设计中的因素，以改善 PICU警告工具的实现。 这项工作非常重要，因为它着重于开发和实施有效的健康信息 技术干预以提高医疗保健质量。它利用健康信息的能力 提高最高风险儿科患者护理质量，效率和有效性的技术。尽管 这项培训补助金的重点是改善科学工作中的健康IT，它也解决了 设计，使用和影响结果的研究领域。通过1型有效性实施 混合设计，Dewan博士将确定障碍和促进者，以促进成功 从学术研究工具转换为实施良好的临床决策支持工具 常规练习。