AHRQ Mentored Clinical Scientist Research Career Development Award (K08): Maya Dewan

AHRQ 指导临床科学家研究职业发展奖 (K08)：Maya Dewan

• 批准号: 10374768
• 负责人: Maya L Dewan
• 金额: $ 14.99万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10374768
• 关键词: AHRQ; Mentored; Clinical; Scientist; Research

PROJECT ABSTRACT Pediatric in-hospital cardiac arrest most commonly occurs in the pediatric intensive care unit and carries extensive morbidity and mortality. This proposal describes a 5-year research and training program that will allow Dr. Maya Dewan to address the prevention of pediatric cardiac arrest through clinical decision support and implementation science. Having completed fellowship training in pediatric critical care medicine and building on a background of improvement science, epidemiology/biostatistics, and clinical informatics the applicant seeks to develop new knowledge and skills to use design informed clinical decision support and implementation science to improve the care and outcomes for critically ill children. This application seeks to address prevention of pediatric cardiac arrest. Prevention of cardiac arrest events is feasible because children often display warning signs prior to deterioration. The applicant’s preliminary studies demonstrate that prediction of pediatric patients at high-risk for clinical deterioration is feasible. The specific aims of the proposed investigations are to: 1) To prospectively validate the PICU Warning Tool to predict clinical deterioration, 2) To evaluate the impact on prediction and situational awareness of adding manual high- risk criteria to the automated PICU Warning Tool, 3) To elucidate factors in system design that will improve implementation of the PICU Warning Tool. This work is significant as it focuses on the development and implementation of an effective health information technology intervention to improve health care quality. It leverages the capability of health information technology to improve quality, efficiency, and effectiveness of care for the highest risk pediatric patients. While this training grant focuses on the implementation of health IT in improvement science work, it also addresses the research areas of design, use, and impact on outcomes. Through a Type 1 effectiveness-implementation hybrid design, Dr. Dewan will identify barriers and facilitators to implementation to facilitate a successful translation from an academic research tool to a well implemented clinical decision support tool suitable for routine practice.

项目摘要 儿科院内心脏骤停最常发生在儿科重症监护室，并携带 广泛的发病率和死亡率。该提案描述了一项为期 5 年的研究和培训计划，该计划将 让 Maya Dewan 博士通过临床决策支持解决儿童心脏骤停的预防问题 和实施科学。完成儿科重症监护医学进修培训并 以改进科学、流行病学/生物统计学和临床​​信息学为背景 申请人寻求发展新的知识和技能，以使用设计知情的临床决策支持和 实施科学以改善危重儿童的护理和结果。 该应用旨在解决儿童心脏骤停的预防问题。预防心脏骤停事件的方法是 可行，因为儿童在病情恶化之前通常会表现出警告信号。申请人的初步研究 证明预测临床恶化高风险的儿科患者是可行的。具体的 拟议调查的目的是： 1) 前瞻性验证 PICU 警告工具来预测 临床恶化，2）评估添加手动高位对预测和态势感知的影响 自动 PICU 警告工具的风险标准，3) 阐明系统设计中可改善的因素 实施 PICU 警告工具。 这项工作意义重大，因为它侧重于有效的健康信息的开发和实施 技术干预提高医疗保健质量。它利用健康信息的能力 旨在提高高风险儿科患者护理质量、效率和效果的技术。尽管 该培训补助金的重点是在改进科学工作中实施卫生信息技术，它还涉及 设计、使用和对结果的影响的研究领域。通过 1 类有效性实施 混合设计，Dewan 博士将确定实施的障碍和促进因素，以促进成功 从学术研究工具转变为适用于实施良好的临床决策支持工具 日常练习。