AHRQ Mentored Clinical Scientist Research Career Development Award (K08): Maya Dewan

AHRQ 指导临床科学家研究职业发展奖 (K08)：Maya Dewan

• 批准号: 10597999
• 负责人: Maya L Dewan
• 金额: $ 15.04万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10597999
• 关键词: AHRQ; Mentored; Clinical; Scientist; Research

PROJECT ABSTRACT Pediatric in-hospital cardiac arrest most commonly occurs in the pediatric intensive care unit and carries extensive morbidity and mortality. This proposal describes a 5-year research and training program that will allow Dr. Maya Dewan to address the prevention of pediatric cardiac arrest through clinical decision support and implementation science. Having completed fellowship training in pediatric critical care medicine and building on a background of improvement science, epidemiology/biostatistics, and clinical informatics the applicant seeks to develop new knowledge and skills to use design informed clinical decision support and implementation science to improve the care and outcomes for critically ill children. This application seeks to address prevention of pediatric cardiac arrest. Prevention of cardiac arrest events is feasible because children often display warning signs prior to deterioration. The applicant’s preliminary studies demonstrate that prediction of pediatric patients at high-risk for clinical deterioration is feasible. The specific aims of the proposed investigations are to: 1) To prospectively validate the PICU Warning Tool to predict clinical deterioration, 2) To evaluate the impact on prediction and situational awareness of adding manual high- risk criteria to the automated PICU Warning Tool, 3) To elucidate factors in system design that will improve implementation of the PICU Warning Tool. This work is significant as it focuses on the development and implementation of an effective health information technology intervention to improve health care quality. It leverages the capability of health information technology to improve quality, efficiency, and effectiveness of care for the highest risk pediatric patients. While this training grant focuses on the implementation of health IT in improvement science work, it also addresses the research areas of design, use, and impact on outcomes. Through a Type 1 effectiveness-implementation hybrid design, Dr. Dewan will identify barriers and facilitators to implementation to facilitate a successful translation from an academic research tool to a well implemented clinical decision support tool suitable for routine practice.

项目摘要 儿科院内心脏骤停最常发生在儿科重症监护室， 广泛的发病率和死亡率。该提案描述了一项为期5年的研究和培训计划， 允许Maya Dewan博士通过临床决策支持来预防儿童心脏骤停 和实施科学。完成儿科重症监护医学研究员培训， 建立在改进科学，流行病学/生物统计学和临床信息学的背景上， 申请人寻求发展新的知识和技能，以使用设计知情的临床决策支持， 实施科学，以改善重症儿童的护理和结果。 本申请寻求解决儿科心脏骤停的预防。预防心脏骤停事件是 这是可行的，因为儿童在病情恶化前往往会出现警告信号。申请人的初步研究 证明预测儿科患者临床恶化的高风险是可行的。具体 拟议调查的目的是：1）前瞻性验证PICU警告工具，以预测 临床恶化，2）评估增加手动高- 自动化PICU警告工具的风险标准，3）阐明系统设计中的因素， 使用PICU警告工具。 这项工作意义重大，因为它侧重于制定和实施有效的卫生信息系统， 技术干预，提高医疗质量。它利用了健康信息的能力， 技术，以提高最高风险儿科患者的护理质量，效率和有效性。而 这项培训补助金的重点是在改善科学工作中实施卫生信息技术，它还涉及 设计，使用和对结果的影响的研究领域。通过类型1有效性实施 混合设计，Dewan博士将确定实施的障碍和促进因素，以促进成功的 从学术研究工具到实施良好的临床决策支持工具的转换， 例行训练