Mentored Vision Clinician-Scientist Program at OHSU

项目总结 基础科学技术的进步正在以前所未有的速度发展。培训下一个 一代视觉科学家如何利用这些知识创造新的临床和公共卫生 干预措施对于减少失明的频率和严重程度至关重要，这是公众对 毁灭性的个人和社会代价。不幸的是，眼科医生往往缺乏 设想如何利用基础和临床研究的最新进展来改善患者护理和视觉 科学家往往缺乏临床视角，无法找出可以指导他们研究的患者护理方面的差距。这 应用程序建议在俄勒冈州健康与科学学院创建机构K12指导体验 大学(OHSU)为初级临床医生科学家教员谁是在他们的头几年的培训。这 该计划的总体目标是让这些有前途的人为成功的、独立的学术和 通过提供教学教育和密集的指导性研究在视觉科学研究中的科学职业 在多学科环境中的经验。OHSU的视力研究和培训环境非常好 协作和跨学科，在将研究从BASE转化为BASE方面提供强有力的方案支持 在床边，如基因治疗，分子遗传学，药物开发，临床试验，眼科 成像、动物模型开发和生物医学信息学。这所大学有顶尖的教育项目 在临床眼科和基础视觉科学方面，并已跻身NEI全国前5名- 在过去的几年里，蓝岭医学研究所一直在支持这项研究。这次培训 计划将填补教育方面的一个重要空白；目前OHSU(或旧金山以北)还没有计划 旧金山和芝加哥以西)，支持临床医生和科学家在视觉科学和 眼科。具体地说，我们提出了一项计划，该计划将在任何给定时间支持两名K12接受者 不同的职业阶段，由咨询委员会选择。培训将由四个主要部分组成：(1) 与导师和合作者一起的个性化研究项目，(2)基础教学课程 基础、临床和转化性视觉科学以及通过俄勒冈州的临床研究计划 临床与翻译研究所(OCTRI)，如人类研究计划(HIP)和 临床研究硕士项目，(3)由项目教职员工和 眼科，以及(4)负责任的研究行为培训。我们相信这个项目 将为现有基础科学和基础科学背景的受训者提供临床前景 背景：已有临床眼科背景的受训者。OHSU是一个严格的环境 通过K12计划进行的基础和临床研究培训将提供有前途的初级临床医生科学家 拥有支持和背景的教职员工，使他们能够实现成为 独立视力科学家、临床医生和教育工作者。

PROJECT SUMMARY Advances in basic science and technology are occurring at an unprecedented pace. Training the next generation of vision scientists in how to use this knowledge to create new clinical and public health interventions is critical toward reducing the frequency and severity of blindness, a major public fear with devastating individual and societal costs. Unfortunately, ophthalmologists often lack the background to envision how to use recent advances in basic and clinical research to improve patient care, and visual scientists often lack the clinical perspective to identify gaps in patient care that could guide their research. This application proposes to create an institutional K12 mentored experience at the Oregon Health & Science University (OHSU) for junior clinician scientist faculty who are in their first few years out of training. This program's overall goal is to prepare these promising individuals for successful, independent academic and scientific careers in vision science research by providing didactic education and intensive mentored research experience in a multidisciplinary environment. The vision research and training environment at OHSU is highly collaborative and interdisciplinary, with strong programmatic support in translation of research from bench to bedside in areas such as gene therapy, molecular genetics, drug development, clinical trials, ophthalmic imaging, animal model development and biomedical informatics. The university has top educational programs in clinical ophthalmology and basic visual science, and has been ranked in the top 5 nationally in NEI- supported research by the Blue Ridge Institute for Medical Research for the past several years. This training program will fill an important gap in education; currently there are no programs at OHSU (or north of San Francisco and west of Chicago) which support the training of clinician-scientists in visual science and ophthalmology. Specifically, we propose a program that will support two K12 recipients at any given time, at different career stages, chosen by an Advisory Committee. Training will consist of four key components: (1) Individualized research projects with mentors and collaborators, (2) A didactic course in the fundamentals of basic, clinical, and translational vision science and access to clinical research programs through the Oregon Clinical & Translational Research Institute (OCTRI), such as the Human Investigations Program (HIP) and Master of Clinical Research Program, (3) Regular research seminars hosted by program faculty and the ophthalmology department, and (4) Training in responsible conduct of research. We believe that this program will provide clinical perspective to trainees with existing backgrounds in basic science, and basic science background to trainees with existing backgrounds in clinical ophthalmology. OHSU is a setting where rigorous training in basic and clinical research through this K12 program will provide promising junior clinician scientist faculty members with the support and background to allow them to realize their career goals of becoming independent vision scientists, clinicians and educators.