Yale Core Grant for Vision Research

耶鲁大学视觉研究核心补助金

• 批准号: 10705290
• 负责人: Jonathan B Demb
• 金额: $ 66.53万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705290
• 关键词: Appointment; Basic Science; Behavior; Behavioral; Biological Models; Cell Culture Techniques; Cells; Computers; Core Grant; Custom; DNA; Department chair; Dependovirus; Development; Environment; Faculty; Fishes; Fostering; Foundations; Functional Imaging; Funding; Future; Genotype; Histology; Human; Image; Individual; Infrastructure; Institution; Investments; Laboratories; Microscope; Minor; Molecular Biology; Mus; Neurosciences; Ophthalmology; Production; Protocols documentation; Research; Research Methodology; Research Personnel; Research Project Grants; Research Project Summaries; Resources; Retina; Services; Techniques; Technology; Thalamic structure; Tissues; Training; Universities; Virus; Vision; Vision research; Visual Cortex; Visual System; cellular imaging; collaborative environment; design; fabrication; fly; innovation; innovative technologies; interest; neurotechnology; nonhuman primate; programs; recruit; superior colliculus Corpora quadrigemina; trend; vision development; vision science

Yale Core Grant for Vision Research Project Summary The overall objective of the Yale Vision Research Core Program is to provide fundamental and innovative technologies to support and enhance vision research at Yale University. With three key resource/service Core modules, this Program will aid the ongoing research projects of vision investigators by providing facilities and expertise that cannot be readily supported by individual research grants. The Core grant will facilitate a collaborative environment that increases the scientific interactions between vision researchers and extends interactions to researchers in other fields. The Core grant will facilitate the development of vision research programs for new investigators at Yale and for established investigators interested in entering the field of vision research. Three Core modules are proposed to maximize impact on vision research at Yale. A Neurotechnology & Fabrication Core will assist in the design, development and construction of a wide range of custom experimental apparatus for vision research (e.g., microscopes, recording chambers, behavioral rigs). These custom technologies will be used in studies that employ a range of model systems (e.g., fly, fish, mouse, non-human primate, human, cell culture) and levels of analysis (e.g., single cell recording, functional imaging, behavior). This module also supports the development of computer-machine interfaces and minor programming applications. A Virus Production & Molecular Biology Core will produce high quality, high-titer adeno-associated virus (AAV) as well as custom design of DNA constructs for a wide range of applications at multiple levels of the visual system (e.g., retina, thalamus, superior colliculus, visual cortex). This module will also offer consulting services for basic molecular biology and histology techniques, including genotyping and immunostaining. An Imaging Core will provide physical facilities and intellectual resources for state-of- the-art static and dynamic imaging of cells and tissues of the visual system. This module will provide practical and didactic training on microscopes to maintain a high level of proficiency and expertise among vision researchers. These three Core modules comprise a comprehensive Core Program that serves the fundamental needs of vision researchers at Yale University.

耶鲁视觉研究核心基金 项目摘要 耶鲁大学视觉研究核心计划的总体目标是提供基础和创新 技术来支持和加强耶鲁大学的视觉研究。三大关键资源/服务 核心模块，该计划将通过提供视觉研究人员正在进行的研究项目， 这些设施和专业知识不能轻易得到个别研究赠款的支持。核心补助金将 促进协作环境，增加视觉研究人员之间的科学互动 并将互动扩展到其他领域的研究人员。核心补助金将促进 为耶鲁大学的新研究人员和对以下方面感兴趣的已有研究人员提供的愿景研究计划： 进入视觉研究领域。 提出了三个核心模块，以最大限度地提高耶鲁大学视觉研究的影响。神经技术和 制造核心将协助设计，开发和建设一个广泛的定制 用于视觉研究的实验装置（例如，显微镜、记录室、行为装置）。这些 定制技术将用于采用一系列模型系统的研究（例如，苍蝇，鱼，老鼠， 非人灵长类动物、人、细胞培养物）和分析水平（例如，单细胞记录，功能的 成像、行为）。该模块还支持开发计算机-机器接口和次要 编程应用程序。一个病毒生产和分子生物学核心将产生高质量，高滴度 腺相关病毒（AAV）以及DNA构建体的定制设计，用于广泛的应用 在视觉系统的多个级别（例如，视网膜、丘脑、上级丘、视觉皮层）。本模块 还将提供基础分子生物学和组织学技术的咨询服务，包括基因分型 和免疫染色。成像核心将为国家提供物理设施和智力资源， 视觉系统的细胞和组织的最先进的静态和动态成像。本模块将提供 显微镜实用和教学培训，以保持高水平的熟练程度和专业知识 视觉研究者这三个核心模块组成了一个全面的核心计划， 耶鲁大学视觉研究人员的基本需求。

项目成果

Laminar compartmentalization of attention modulation in area V4 aligns with the demands of visual processing hierarchy in the cortex.

• DOI: 10.1038/s41598-023-46722-8
• 发表时间: 2023-11-09
• 期刊: Scientific reports
• 影响因子: 4.6

Object-Displacement-Sensitive Visual Neurons Drive Freezing in Drosophila.

• DOI: 10.1016/j.cub.2020.04.068
• 发表时间: 2020-07-06
• 期刊: Current biology : CB
• 作者: Tanaka R;Clark DA
• 通讯作者: Clark DA

Layer 5 Circuits in V1 Differentially Control Visuomotor Behavior.

V1 中的第 5 层电路差异化地控制视觉运动行为。

• DOI: 10.1016/j.neuron.2019.10.014
• 发表时间: 2020
• 期刊: Neuron
• 影响因子: 16.2
• 作者: Tang,Lan;Higley,MichaelJ
• 通讯作者: Higley,MichaelJ

Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function.

• DOI: 10.1016/j.jtos.2021.08.010
• 发表时间: 2021-10
• 期刊: The ocular surface
• 作者: Thompson B;Chen Y;Davidson EA;Garcia-Milian R;Golla JP;Apostolopoulos N;Orlicky DJ;Schey K;Thompson DC;Vasiliou V
• 通讯作者: Vasiliou V

Rapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals.

视网膜双极神经元突触前末梢膜张力的快速传播。

• DOI: 10.1126/sciadv.abl4411
• 发表时间: 2022
• 期刊: Science advances
• 影响因子: 13.6
• 作者: GomisPerez,Carolina;Dudzinski,NatashaR;Rouches,Mason;Landajuela,Ane;Machta,Benjamin;Zenisek,David;Karatekin,Erdem
• 通讯作者: Karatekin,Erdem