Vector/Host-Parasite Interface of Leishmaniasis in Colombia

描述（由申请人提供）：培训补助金的目标是建立研究能力，以确定战略和设计方法，通过干预无脊椎动物和脊椎动物宿主病原体的相互作用，中断利什曼病的传播和发病周期。为了实现这一目标，培训计划将实施利什曼原虫与白蛉载体和哺乳动物宿主之间相互作用的分子分析研究能力。拟议的计划建立在现有的研究能力和发展中国家机构在皮肤和内脏利什曼病和其他传染病的临床，流行病学和生物学方面的正在进行的项目，与耶鲁大学教师的事先合作，以及教师和基础设施的临界质量进行动质体寄生虫和宿主反应的分子分析。哥伦比亚科学家将在耶鲁大学接受培训，培训方式包括指导研究、审核研究生课程和研究技能短期课程，如生物安全、负责任的研究行为和科学写作。每年将在CIDEIM举办讲习班，耶鲁大学教师参加（现场和电话会议），以培养和提高研究技能，并向国家研究人员介绍分子分析的概念和原则（生物信息学和数据挖掘，功能基因组学，表达分析）。将从哥伦比亚各大学在CIDEIM进行论文研究的研究生中挑选博士前学员。学生将是人类或兽医学和基础科学的应届毕业生，他们有资格获得COLCIENCIAS青年研究者计划框架内的奖学金支持。CIDEIM的研究人员，如果其研究与媒介或宿主-利什曼原虫相互作用有关，将获得为期4个月的博士后培训和科学交流。在该方案的第5年，CIDEIM将向国家和区域学生提供关于宿主（哺乳动物/载体）-pamsite相互作用的分子遗传分析的正式研究生课程。总的来说，所进行的培训将使调查人员在新的研究领域做好准备，通过电话会议进行培训，并确保有能力为哥伦比亚和区域研究生提供正式课程。所有这些都将有助于研究能力的可持续性。

DESCRIPTION (provided by applicant): The goal of the training grant is to build research capacity to identify strategies and devise means to interrupt the cycle of transmission and pathogenesis of leishmaniasis through intervention of the invertebrate and vertebrate host pathogen interactions. To achieve this goal, the training program will implement research capacity in the molecular analysis of the interaction between Leishmania and both the sandfly vector and the mammalian host. The proposed program builds upon the existing research capacity and ongoing projects of the developing country institution in clinical, epidemiological and biological aspects of cutaneous and visceral leishmaniasis and other transmissible diseases, prior collaboration with Yale faculty, and the critical mass of faculty and infrastructure for the conduct of molecular analyses of kinetoplastid parasites and host responses available at Yale University. Colombian scientists will receive training at Yale through the conduct of mentored research, auditing of postgraduate courses and short courses on research skills, such as biosafety, responsible conduct of research, and scientific writing. Workshops will be offered each year at CIDEIM with the participation of Yale Faculty (on site and teleconferencing) to build and multiply research skills and introduce national investigators to concepts and principles of molecular analysis (bioinformatics and data mining, functional genomics, expression analysis). Predoctoral trainees will be selected among postgraduate students from Colombian universities who conduct thesis research in CIDEIM. Students will be recent graduates of human or veterinary medicine and basic science who have qualified for scholarship support within the framework of COLCIENCIAS' Young Investigator program. Post-doctoral training and scientific exchange for periods of up to 4 months will be available to research staff of CIDEIM whose research is relevant to the vector or host- Leishmania interaction. During year 5 of the program, formal postgraduate courses on the molecular genetic analyses of host (mammalian/vector)-pamsite interactions will be offered to national and regional students by CIDEIM. Overall, the training conducted will prepare investigators in new areas of research, implement training by teleconferencing, and assure the capacity to offer formal courses for Colombian and regional post-graduate students. All of these will contribute to the sustainability of research capacity.