Vector/Host-Parasite Interface of Leishmaniasis in Colombia

描述(申请人提供)：培训资助的目标是建立研究能力，以确定通过干预无脊椎动物和脊椎动物宿主病原体的相互作用来中断利什曼病传播和发病循环的策略和方法。为了实现这一目标，培训计划将加强利什曼原虫与沙蝇媒介和哺乳动物宿主之间相互作用的分子分析方面的研究能力。拟议的计划建立在发展中国家机构在皮肤和内脏利什曼病和其他传染性疾病的临床、流行病学和生物学方面的现有研究能力和正在进行的项目的基础上，事先与耶鲁大学的教职员工合作，以及耶鲁大学提供的对动粒体寄生虫和宿主反应进行分子分析的关键教员和基础设施。哥伦比亚科学家将在耶鲁接受指导研究、研究生课程审计和研究技能短期课程的培训，如生物安全、负责任的研究行为和科学写作。每年将在CIDEIM举办研讨会，由耶鲁大学教职员工参加(现场和电话会议)，以培养和提高研究技能，并向国家研究人员介绍分子分析(生物信息学和数据挖掘、功能基因组学、表达分析)的概念和原理。博士前实习生将从哥伦比亚大学在CIDEIM进行论文研究的研究生中挑选出来。学生将是人类或兽医学和基础科学的应届毕业生，他们有资格获得COLCIENCIAS青年研究员计划框架内的奖学金支持。CIDEIM的研究人员将接受为期4个月的博士后培训和科学交流，他们的研究与病媒或宿主-利什曼病的相互作用有关。在该计划的第五年，CIDEIM将向国家和地区的学生提供关于宿主(哺乳动物/载体)-PAMSITE相互作用的分子遗传学分析的正式研究生课程。总体而言，开展的培训将使调查人员在新的研究领域做好准备，通过电话会议进行培训，并确保有能力为哥伦比亚和区域研究生提供正式课程。所有这些都将有助于研究能力的可持续性。

DESCRIPTION (provided by applicant): The goal of the training grant is to build research capacity to identify strategies and devise means to interrupt the cycle of transmission and pathogenesis of leishmaniasis through intervention of the invertebrate and vertebrate host pathogen interactions. To achieve this goal, the training program will implement research capacity in the molecular analysis of the interaction between Leishmania and both the sandfly vector and the mammalian host. The proposed program builds upon the existing research capacity and ongoing projects of the developing country institution in clinical, epidemiological and biological aspects of cutaneous and visceral leishmaniasis and other transmissible diseases, prior collaboration with Yale faculty, and the critical mass of faculty and infrastructure for the conduct of molecular analyses of kinetoplastid parasites and host responses available at Yale University. Colombian scientists will receive training at Yale through the conduct of mentored research, auditing of postgraduate courses and short courses on research skills, such as biosafety, responsible conduct of research, and scientific writing. Workshops will be offered each year at CIDEIM with the participation of Yale Faculty (on site and teleconferencing) to build and multiply research skills and introduce national investigators to concepts and principles of molecular analysis (bioinformatics and data mining, functional genomics, expression analysis). Predoctoral trainees will be selected among postgraduate students from Colombian universities who conduct thesis research in CIDEIM. Students will be recent graduates of human or veterinary medicine and basic science who have qualified for scholarship support within the framework of COLCIENCIAS' Young Investigator program. Post-doctoral training and scientific exchange for periods of up to 4 months will be available to research staff of CIDEIM whose research is relevant to the vector or host- Leishmania interaction. During year 5 of the program, formal postgraduate courses on the molecular genetic analyses of host (mammalian/vector)-pamsite interactions will be offered to national and regional students by CIDEIM. Overall, the training conducted will prepare investigators in new areas of research, implement training by teleconferencing, and assure the capacity to offer formal courses for Colombian and regional post-graduate students. All of these will contribute to the sustainability of research capacity.