Mobile Combined Alcohol and HIV Prevention Including PrEP Uptake/Adherence for High-Risk Young Men
移动酒精和艾滋病毒联合预防,包括高危年轻男性的 PrEP 摄取/坚持
基本信息
- 批准号:10020295
- 负责人:
- 金额:$ 38.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAddressAdherenceAftercareAgeAlcohol consumptionAlcohol or Other Drugs useAlcoholsAreaBenchmarkingBloodDataEducationElementsEnsureFeedbackFloridaFocus GroupsGoalsHIVHIV InfectionsHIV SeronegativityHIV riskHeavy DrinkingHispanicsIndividualInternetInterventionIntervention StudiesLatinoMediator of activation proteinMonitorMotivationNational Institute on Alcohol Abuse and AlcoholismOnline SystemsOutcomeParticipantPhasePreventionPreventivePreventive InterventionRadialRandomizedReportingRiskRisk BehaviorsRuralSex BehaviorStandardizationSurveysTestingTherapeuticUnsafe SexVoicealcohol contentalcohol preventionavoidance of risky sexual behaviorbasebrief motivational interventioncost effectivedesigndrinkingfollow-upgroup interventionhigh riskhigh risk menhigh risk populationinfection riskinnovationlow socioeconomic statusmedication compliancemen who have sex with menopen labelpre-exposure prophylaxispreventrecruitreduced alcohol useresponserisk perceptionsexsexual risk behaviorsuccesstheoriestreatment adherenceuptakeusabilityyoung adultyoung manyoung men who have sex with men
项目摘要
PROJECT SUMMARY
The rate of new HIV infections remains unacceptable, particularly in Florida and among men who have sex
with men (MSM). Black and Hispanic/Latino, as well as young adult MSM are at particularly high risk, due in
part to overlapping risk behaviors like heavy drinking. Alcohol use increases unprotected sex and reduces
treatment adherence, making combined alcohol and risky sex prevention optimal. New preventive efforts for
HIV and alcohol are a high priority area for NIAAA and must be targeted to these highest-risk groups. The goal
of this UH2/UH3 project is to develop and test initially a synergistic, mobile intervention that will reduce alcohol
use and risky sex and prevent HIV infection among the highest-risk individuals. The proposed intervention
combines brief motivational intervention; daily monitoring via interactive voice response (IVR) with
personalized feedback; and pre-exposure prophylaxis (PrEP). Combining them offers the strengths of all 3
while compensating for limitations of each, yielding a combined intervention with great potential impact. Based
on theory and prior evidence, we hypothesize that this combined preventive intervention will be associated with
greater alcohol use reduction and medication adherence than a standardized educational control condition.
This project is innovative in that this combination of 3 efficacious interventions has not been tested to reduce
alcohol use and HIV risk. Further, there are no established interventions to enhance PrEP uptake/adherence
and no studies have provided intervention targeting both alcohol and PrEP uptake/adherence. In the UH2
phase, we will recruit MSM ages 18-30 who report HIV-negative status for a web survey (N=683) to yield
normative data for the personalized feedback intervention component and focus groups (N=30) to provide
input on the initial version of the intervention. Based on the web survey and focus groups, the intervention will
be modified and tested in a preliminary usability study (N=10) to prepare for the UH3 phase. Completing each
benchmark of the UH2 phase indicates feasibility of the UH3 intervention study. For the UH3 phase, we will
recruit higher-risk MSM (N=80) for a 30-day study to test the combined mobile alcohol and HIV preventive
intervention. All participants will receive open-label PrEP and complete a 5-minute daily IVR assessment of
alcohol/substance use, sexual behavior and PrEP taking. Participants randomized to intervention will get brief
web-based alcohol and HIV prevention followed by IVR monitoring including personalized feedback. The web-
based component is designed to increase risk perception and motivation to change while the IVR component
will enhance PrEP adherence and bolster risk perception and motivation further. Participants randomized to
control will get standardized education, not personalized intervention, and give IVR responses for assessment
purposes only with no feedback. Follow-up will occur at the end of the 30-day intervention and 6-months post-
treatment. This project represents an early step in developing and testing a cost-effective, scalable preventive
intervention that will be readily accessible, even to rural and lower socioeconomic status individuals.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROBERT F LEEMAN其他文献
ROBERT F LEEMAN的其他文献
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{{ truncateString('ROBERT F LEEMAN', 18)}}的其他基金
Development and Initial Testing of a Multi-Component Breath Alcohol-Focused Intervention for Young Adults
针对年轻人的多成分呼吸酒精干预措施的开发和初步测试
- 批准号:
10755467 - 财政年份:2023
- 资助金额:
$ 38.13万 - 项目类别:
Linking Impulsivity Domains and Subjective Response to Alcohol in Young Adults Using Lab and Daily Assessment Methods
使用实验室和日常评估方法将年轻人的冲动域和对酒精的主观反应联系起来
- 批准号:
10453125 - 财政年份:2022
- 资助金额:
$ 38.13万 - 项目类别:
Linking Impulsivity Domains and Subjective Response to Alcohol in Young Adults Using Lab and Daily Assessment Methods
使用实验室和日常评估方法将年轻人的冲动域和对酒精的主观反应联系起来
- 批准号:
10706464 - 财政年份:2022
- 资助金额:
$ 38.13万 - 项目类别:
Novel Extensions of Alcohol Contingency Management in People Living with HIV
艾滋病毒感染者酒精应急管理的新扩展
- 批准号:
10304325 - 财政年份:2021
- 资助金额:
$ 38.13万 - 项目类别:
Novel Extensions of Alcohol Contingency Management in People Living with HIV
艾滋病毒感染者酒精应急管理的新扩展
- 批准号:
10682456 - 财政年份:2021
- 资助金额:
$ 38.13万 - 项目类别:
Mobile Combined Alcohol and HIV Prevention Including PrEP Uptake/Adherence for High-Risk Young Men
移动酒精和艾滋病毒联合预防,包括高危年轻男性的 PrEP 摄取/坚持
- 批准号:
10242805 - 财政年份:2017
- 资助金额:
$ 38.13万 - 项目类别:
Mobile Combined Alcohol and HIV Prevention Including PrEP Uptake/Adherence for High-Risk Young Men
移动酒精和艾滋病毒联合预防,包括高危年轻男性的 PrEP 摄取/坚持
- 批准号:
10840225 - 财政年份:2017
- 资助金额:
$ 38.13万 - 项目类别:
Mobile Combined Alcohol and HIV Prevention Including PrEP Uptake/Adherence for High-Risk Young Men
移动酒精和艾滋病毒联合预防,包括高危年轻男性的 PrEP 摄取/坚持
- 批准号:
9564824 - 财政年份:2017
- 资助金额:
$ 38.13万 - 项目类别:
Testing a Smartphone Breathalyzer and BAC Estimator in Young Adult Heavy Drinkers
在年轻成年酗酒者中测试智能手机呼气分析仪和 BAC 估算器
- 批准号:
9282848 - 财政年份:2016
- 资助金额:
$ 38.13万 - 项目类别:
Testing a Smartphone Breathalyzer and BAC Estimator in Young Adult Heavy Drinkers
在年轻成年酗酒者中测试智能手机呼气分析仪和 BAC 估算器
- 批准号:
9212072 - 财政年份:2016
- 资助金额:
$ 38.13万 - 项目类别:
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