P30 Core Grant for Vision Research

P30 视觉研究核心资助

• 批准号: 10020564
• 负责人: David H Brainard
• 金额: $ 64.79万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10020564
• 关键词: Affect; Animal Model; Basic Science; Bioinformatics; Biometry; Blindness; Cellular biology; Clinical Research; Collaborations; Computer Models; Confocal Microscopy; Core Grant; Custom; Data; Data Analyses; Disease; Electrophysiology (science); Equipment; Experimental Designs; Eye; Goals; Grant; Image; In Vitro; Maintenance; Molecular Biology; Molecular Genetics; National Eye Institute; Pennsylvania; Physiology; Primates; Public Health; Qualifying; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Retina; Retinal Degeneration; Savings; Scientist; Services; Software Tools; Source; Stimulus; Tissues; Universities; Vision; Vision research; Visual Cortex; Visual Pathways; Visual Psychophysics; Visual impairment; awake; cognitive neuroscience; data acquisition; data curation; design and construction; gene therapy; imaging modality; insight; instrument; instrumentation; multi-electrode arrays; novel; programs; ranpirnase; recruit; repaired; skills; two-photon; visual performance

Overall - Project Summary The broad goal of this proposal is to provide core support services for 16 Participating Investigators and over 40 Associate Investigators to: (1) enhance the quality and quantity of their research; (2) facilitate collaborations between investigators with different backgrounds and skills; and (3) recruit new investigators to vision research, help young vision investigators establish their labs, and allow established investigators to explore new directions. The Participating Investigators hold 18 qualifying R01 research grants from the National Eye Institute. The Associate Investigators study vision but do not currently hold a qualifying R01 grant from the NEI. Collectively, the investigators represent a broad range of vision research, and include experts on animal models of retinal degeneration, retinal circuitry, gene therapy, cell and molecular biology, molecular genetics, eye, central visual pathways and cortical physiology, visual performance and cortical function in awake- behaving primates, cognitive neuroscience of vision, computational modeling, and visual psychophysics. The core grant will support 4 resource/service modules: Biostatistics provides expert assistance in experimental design and data analysis, particularly for clinical studies, as well as bioinformatics support; Imaging and Electrophysiology provides vision investigators access to shared equipment and technical support for a variety of imaging modalities and electrophysiological recording, including conventional and two-photon confocal microscopy, multi-electrode array recording from in vitro tissue, and spectral OCT imaging; Instrumentation provides for design and construction of custom stimulus delivery, data acquisition, and electrophysiological instruments that are unavailable from commercial sources, as well as maintenance and repair of such instruments; Scientific Transparency develops novel software tools for pre-processing, analysis, and presentation of imaging data, and supports data curation and analysis reproducibility.

总体-项目摘要 本提案的总体目标是为16名及以上参与研究者提供核心支持服务 40名助理研究员：（1）提高研究质量和数量;（2）促进合作 不同背景和技能的研究者之间的交流;（3）招募新的研究者， 研究，帮助年轻的视力研究人员建立他们的实验室，并允许成熟的研究人员进行探索 新方向参与研究者持有18项国家眼研究的合格R 01研究赠款 院助理研究员研究愿景，但目前没有从NEI获得合格的R 01资助。 总的来说，研究人员代表了广泛的视觉研究，包括动物视觉方面的专家。 视网膜变性模型，视网膜回路，基因治疗，细胞和分子生物学，分子遗传学， 眼，中枢视觉通路和皮层生理学，视觉性能和皮层功能在清醒时， 行为灵长类动物，视觉认知神经科学，计算建模和视觉心理物理学。的 核心拨款将支持4个资源/服务单元：生物统计学提供专家援助， 设计和数据分析，特别是临床研究，以及生物信息学支持;成像和 电生理学为视觉研究人员提供共享设备和技术支持， 各种成像模式和电生理记录，包括常规和双光子 共焦显微镜、来自体外组织的多电极阵列记录和光谱OCT成像; 仪器仪表提供定制刺激传递、数据采集和分析的设计和构造。 无法从商业来源获得的电生理仪器，以及维护和 这些仪器的维修; Scientific Transparency开发了用于预处理的新型软件工具， 分析和呈现成像数据，并支持数据管理和分析再现性。