P-30 Core Grant for Vision Research

P-30 视觉研究核心补助金

• 批准号: 8123236
• 负责人: David H Brainard
• 金额: $ 76.91万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8123236
• 关键词: Affect; Animal Model; Basic Science; Biological Preservation; Biometry; Blindness; Cancer Center Support Grant; Cellular biology; Clinical Research; Collaborations; Communities; Computer Simulation; Conduct Clinical Trials; Confocal Microscopy; Consult; Data Analyses; Development; Disease; Electrodes; Equipment; Experimental Designs; Eye; Fostering; Funding; Goals; Grant; Human; Human Resources; Image; Image Analysis; Imaging technology; In Vitro; Individual; Life; Methods; Microscope; Mission; Molecular Biology; Molecular Genetics; Optics; Pennsylvania; Physiological; Physiology; Primates; Printing; Psychophysics; Public Health; Qualifying; Recruitment Activity; Research; Research Personnel; Research Project Grants; Research Support; Retina; Retinal; Retinal Degeneration; Running; Scientist; Services; Solutions; Source; Technical Expertise; Tissues; Universities; Vision; Vision research; Visual Cortex; Visual Pathways; Visual Psychophysics; Visual impairment; Work; awake; cognitive neuroscience; cost; design and construction; gene therapy; imaging modality; in vivo; insight; instrument; instrumentation; meetings; posters; programs; ranpirnase; skills; two-photon; visual performance

DESCRIPTION (provided by applicant): The broad goal of this proposal is to provide core support services for 26 Participating Investigators and 24 Associate Investigators to: (1) enhance the quality and quantity of their research; (2) facilitate collaborations between investigators with different backgrounds and skills; and (3) recruit new investigators to vision research, help young vision investigators establish their labs, and allow established investigators to explore new directions. Participating Investigators hold P30-qualifying individual research grants from NEI, and Associate Investigators hold individual grants from other sources or are applying for funding. Collectively the investigators represent a broad range of vision research, and include experts on animal models of retinal degeneration, retinal circuitry, gene therapy, cell and molecular biology, molecular genetics, eye, central visual pathways and cortical physiology, visual performance and cortical function in awake-behaving primates, cognitive neuroscience of vision, computational modeling, and visual psychophysics. The core grant will support 5 modules: Biostatistics provides expert assistance in experimental design and data analysis particularly for clinical studies; Image Analysis provides expert support for the development and implementation of image analysis solutions; Instrumentation provides for design and construction of optical and electrophysiological instruments that are unavailable from commercial sources; Noninvasive Assessment of Visual Function provides equipment and technical support for assessing visual function in animal models and humans. Principle methods include ERG, pupillometry, and psychophysics; Shared Imaging Equipment provides vision investigators access to shared equipment for a variety of imaging modalities, including conventional and two-photon confocal microscopy, multi-electrode array recording from in vitro tissue, and confocal SLO combined with spectral OCT imaging of in vivo retina.

描述（由申请人提供）：本提案的总体目标是为26名参与研究者和24名副研究者提供核心支持服务，以：(1)提高他们研究的质量和数量；(2)促进不同背景和技能的调查人员之间的合作；(3)招募新的视觉研究人员，帮助年轻的视觉研究人员建立自己的实验室，并允许已有的研究人员探索新的方向。参与研究者持有来自NEI的p30资格的个人研究资助，副研究者持有来自其他来源的个人资助或正在申请资助。这些研究人员代表了广泛的视觉研究领域，包括视网膜变性动物模型、视网膜电路、基因治疗、细胞和分子生物学、分子遗传学、眼睛、中央视觉通路和皮质生理学、清醒行为灵长类动物的视觉表现和皮质功能、视觉认知神经科学、计算建模和视觉心理物理学等方面的专家。核心拨款将支持5个模块：生物统计学为临床研究提供实验设计和数据分析方面的专家协助；图像分析为图像分析解决方案的开发和实施提供专家支持；仪器仪表提供了从商业来源无法获得的光学和电生理仪器的设计和构造；无创视觉功能评估为动物模型和人类视觉功能评估提供了设备和技术支持。主要方法包括ERG、瞳孔测量法和心理物理学；共享成像设备为视觉研究人员提供了各种成像方式的共享设备，包括传统和双光子共聚焦显微镜，体外组织的多电极阵列记录，以及共聚焦SLO结合体内视网膜的光谱OCT成像。