P-30 Core Grant for Vision Research

P-30 视觉研究核心补助金

• 批准号: 8528597
• 负责人: David H Brainard
• 金额: $ 76.91万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528597
• 关键词: Affect; Animal Model; Basic Science; Biological Preservation; Biometry; Blindness; Cancer Center Support Grant; Cellular biology; Clinical Research; Collaborations; Communities; Computer Simulation; Conduct Clinical Trials; Confocal Microscopy; Consult; Data Analyses; Development; Disease; Electrodes; Equipment; Experimental Designs; Eye; Fostering; Funding; Goals; Grant; Human; Human Resources; Image; Image Analysis; Imaging technology; In Vitro; Individual; Life; Methods; Microscope; Mission; Molecular Biology; Molecular Genetics; Optics; Pennsylvania; Physiological; Physiology; Primates; Printing; Psychophysics; Public Health; Qualifying; Recruitment Activity; Research; Research Personnel; Research Project Grants; Research Support; Retina; Retinal; Retinal Degeneration; Running; Scientist; Services; Solutions; Source; Technical Expertise; Tissues; Universities; Vision; Vision research; Visual Cortex; Visual Pathways; Visual Psychophysics; Visual impairment; Work; awake; cognitive neuroscience; cost; design and construction; gene therapy; imaging modality; in vivo; insight; instrument; instrumentation; meetings; posters; programs; ranpirnase; skills; two-photon; visual performance

DESCRIPTION (provided by applicant): The broad goal of this proposal is to provide core support services for 26 Participating Investigators and 24 Associate Investigators to: (1) enhance the quality and quantity of their research; (2) facilitate collaborations between investigators with different backgrounds and skills; and (3) recruit new investigators to vision research, help young vision investigators establish their labs, and allow established investigators to explore new directions. Participating Investigators hold P30-qualifying individual research grants from NEI, and Associate Investigators hold individual grants from other sources or are applying for funding. Collectively the investigators represent a broad range of vision research, and include experts on animal models of retinal degeneration, retinal circuitry, gene therapy, cell and molecular biology, molecular genetics, eye, central visual pathways and cortical physiology, visual performance and cortical function in awake-behaving primates, cognitive neuroscience of vision, computational modeling, and visual psychophysics. The core grant will support 5 modules: Biostatistics provides expert assistance in experimental design and data analysis particularly for clinical studies; Image Analysis provides expert support for the development and implementation of image analysis solutions; Instrumentation provides for design and construction of optical and electrophysiological instruments that are unavailable from commercial sources; Noninvasive Assessment of Visual Function provides equipment and technical support for assessing visual function in animal models and humans. Principle methods include ERG, pupillometry, and psychophysics; Shared Imaging Equipment provides vision investigators access to shared equipment for a variety of imaging modalities, including conventional and two-photon confocal microscopy, multi-electrode array recording from in vitro tissue, and confocal SLO combined with spectral OCT imaging of in vivo retina.

描述（由申请人提供）：本提案的总体目标是为 26 名参与研究员和 24 名副研究员提供核心支持服务，以：（1）提高研究的质量和数量； (2) 促进不同背景和技能的研究者之间的合作； （3）招募新的研究者进行视觉研究，帮助年轻的视觉研究者建立实验室，并允许老研究者探索新的方向。参与研究人员持有 NEI 的 P30 资格个人研究资助，副研究人员持有其他来源的个人资助或正在申请资助。研究人员共同代表了广泛的视觉研究，包括视网膜变性动物模型、视网膜回路、基因治疗、细胞和分子生物学、分子遗传学、眼睛、中央视觉通路和皮质生理学、清醒灵长类动物的视觉表现和皮质功能、视觉认知神经科学、计算模型和视觉心理物理学的专家。核心拨款将支持 5 个模块： 生物统计学在实验设计和数据分析（特别是临床研究）方面提供专家协助；图像分析为图像分析解决方案的开发和实施提供专家支持；仪器提供了商业来源无法获得的光学和电生理仪器的设计和构造；无创视觉功能评估为评估动物模型和人类视觉功能提供设备和技术支持。主要方法包括 ERG、瞳孔测量和心理物理学；共享成像设备为视觉研究人员提供了多种成像方式的共享设备，包括传统和双光子共焦显微镜、体外组织的多电极阵列记录以及与体内视网膜光谱 OCT 成像相结合的共焦 SLO。