CORE GRANT FOR VISION RESEARCH

愿景研究核心资助

• 批准号: 7679428
• 负责人: David H Brainard
• 金额: $ 64.91万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7679428
• 关键词: CORE; GRANT; VISION; RESEARCH

DESCRIPTION (provided by applicant): The broad goal of this proposal is to provide core support services for 39 principle investigators and 11 associated investigators to: (1) enhance the quality and quantity of their research; (2) facilitate collaborations between investigators with different backgrounds and skills; and (3) recruit new investigators to vision research. The PIs sort into several groups: psychophysics/systems neuroscience, visual transduction/retinal degeneration/gene therapy, eye (lens/ myopia/glaucoma), and clinical research. PIs hold individual research grants from NEI, and Associates hold individual grants from other sources. The Core includes 5 modules: Biostatistics provides expert assistance in experimental design and data analysis particularly for clinical studies. Computation-Illustration provides resources for scientific computing as well as expert computer support. Instrumentation provides for design and construction of optical and electrophysiological instruments that are unavailable from commercial sources. Molecular Biology provides DNA sequencing and gene mapping. Physiological Imaging, proposed here as a new module, would provide a new facility for multi-unit recording and an adjacent facility for optical recording of various functional signals from neural tissue in vitro, such as calcium, while imaging the whole cell by confocal microscopy. This module will greatly enhance the capabilities of the systems investigators and will provide new and efficient functional assays for investigators of molecular genetics and gene therapy. Altogether the Core accelerates our progress, improves opportunities for collaboration and helps translate basic research into clinical application.

该提案的主要目标是为39名主要研究者和11名相关研究者提供核心支持服务，以：（1）提高他们的研究质量和数量;（2）促进具有不同背景和技能的研究者之间的合作;（3）招募新的研究者进行视觉研究。PI分为几个组：心理物理学/系统神经科学，视觉传导/视网膜变性/基因治疗，眼睛（透镜/近视/青光眼）和临床研究。PI持有NEI的个人研究赠款，而Associates持有其他来源的个人赠款。核心包括5个模块： 生物统计学在实验设计和数据分析方面提供专家帮助，特别是临床研究。 计算插图提供科学计算资源以及专家计算机支持。 仪器提供商业来源无法获得的光学和电生理仪器的设计和构造。 分子生物学提供DNA测序和基因图谱。 生理成像，在这里提出作为一个新的模块，将提供一个新的设施，多单元记录和相邻的设施，光学记录的各种功能信号从神经组织在体外，如钙，同时成像的整个细胞的共聚焦显微镜。该模块将大大提高系统研究人员的能力，并将为分子遗传学和基因治疗研究人员提供新的和有效的功能测定。 总而言之，核心加速了我们的进步，改善了合作机会，并有助于将基础研究转化为临床应用。