Core Grant for Vision Research

视觉研究核心资助

• 批准号: 8937173
• 负责人: David H Brainard
• 金额: $ 74.82万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8937173
• 关键词: Affect; Animal Model; Basic Science; Bioinformatics; Biometry; Blindness; Cellular biology; Clinical Research; Collaborations; Computer Simulation; Conduct Clinical Trials; Confocal Microscopy; Core Grant; Custom; Data Analyses; Development; Disease; Electrophysiology (science); Equipment; Experimental Designs; Eye; Goals; Grant; Image; Image Analysis; In Vitro; Individual; Maintenance; Methods; Molecular Biology; Molecular Genetics; National Eye Institute; Pennsylvania; Physiology; Primates; Public Health; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Retinal; Retinal Degeneration; Scientist; Services; Solutions; Source; Stimulus; Tissues; Universities; Vision; Vision Tests; Vision research; Visual Cortex; Visual Pathways; Visual Psychophysics; Visual impairment; Water; Work; awake; cognitive neuroscience; data acquisition; design and construction; gene therapy; image processing; imaging modality; insight; instrument; instrumentation; multi-electrode arrays; programs; public health relevance; repaired; skills; two-photon; visual performance

 DESCRIPTION (provided by applicant): The broad goal of this proposal is to provide core support services for 21 Participating Investigators and over 30 Associate Investigators to: (1) enhance the quality and quantity of their research; (2) facilitate collaborations between investigators with different backgrounds and skills; and (3) recruit new investigators to vision research, help young vision investigators establish their labs, and allow established investigators to explore new directions. Participating Investigators hold 25 individual R01 research grants from the National Eye Institute, and Associate Investigators study vision but do not currently hold an R01 grant from the NEI. Collectively, the investigators represent a broad range of vision research, and include experts on animal models of retinal degeneration, retinal circuitry, gene therapy, cell and molecular biology, molecular genetics, eye, central visual pathways and cortical physiology, visual performance and cortical function in awake- behaving primates, cognitive neuroscience of vision, computational modeling, and visual psychophysics. The core grant will support 5 resource/service modules: Biostatistics provides expert assistance in experimental design and data analysis, particularly for clinical studies, as well as bioinformatics support; Image Analysis provides expert support for the development and implementation of image processing and analysis solutions, as well as other data analysis services; Imaging and Electrophysiology provides vision investigators access to shared equipment and technical support for a variety of imaging modalities and electrophysiological recording, including conventional and two-photon confocal microscopy, multi-electrode array recording from in vitro tissue, and spectral OCT imaging; Instrumentation provides for design and construction of custom stimulus delivery, data acquisition, and electrophysiological instruments that are unavailable from commercial sources, as well as maintenance and repair of such instruments; Noninvasive Assessment of Visual Function provides equipment and technical support for assessing visual function in animal models. Methods include ERG, pupillometry, and water maze testing of vision.

 描述（由申请人提供）：本提案的总体目标是为21名参与研究者和30多名助理研究者提供核心支持服务，以：（1）提高其研究的质量和数量;（2）促进不同背景和技能的研究者之间的合作;以及（3）招募新的视觉研究人员，帮助年轻的视觉研究人员建立他们的实验室，并允许已有的研究人员探索新的方向。参与研究的研究者持有国家眼科研究所的25项个人R 01研究赠款，助理研究者研究视力，但目前未持有NEI的R 01资助。总的来说，研究人员代表了广泛的视觉研究，包括视网膜变性动物模型，视网膜电路，基因治疗，细胞和分子生物学，分子遗传学，眼睛，中央视觉通路和皮层生理学，清醒行为灵长类动物的视觉表现和皮层功能，视觉认知神经科学，计算建模和视觉心理物理学方面的专家。核心拨款将支持5个资源/服务模块：生物统计学在实验设计和数据分析方面提供专家援助，特别是临床研究，以及生物信息学支持;图像分析为图像处理和分析解决方案的开发和实施提供专家支持，以及其他数据分析服务;成像和电生理学为视觉研究人员提供了共享设备和技术支持，用于各种成像模式和电生理记录，包括常规和双光子共聚焦显微镜，多电极阵列记录体外组织和光谱OCT成像;仪器提供定制刺激传递、数据采集和电生理仪器的设计和构造，这些仪器无法从商业来源获得，以及这些仪器的维护和维修;无创性视功能评估为在动物模型中评估视功能提供了设备和技术支持。方法包括ERG、瞳孔测量和水迷宫视觉测试。