Transcriptional regulation of T cell immunity

T细胞免疫的转录调控

• 批准号: 10008141
• 负责人: John T Chang
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10008141
• 关键词: Acute; Adoptive Transfer; Bacterial Infections; Body Surface; CD8-Positive T-Lymphocytes; Cells; Chronic; Colon; Communicable Diseases; Cytometry; Data; Effector Cell; Face; Gene Expression; Gene Expression Profiling; Gene Targeting; Genes; Genetic Transcription; Goals; HIV/HCV; Health; Heterogeneity; Host Defense; Immune response; Immune system; Immunity; Immunologic Memory; Infection; Kidney; Liver; Measurement; Memory; Methods; Molecular; Morbidity - disease rate; Pathway interactions; Phase; Population; Proteins; RNA Interference; Reporting; Sentinel; Small Intestines; Specific qualifier value; T cell regulation; T memory cell; Tissues; Transcriptional Regulation; Transgenic Organisms; Vaccine Design; Vaccines; Validation; Veterans; Work; adaptive immunity; antigen-specific T cells; base; cell type; first responder; genome-wide; improved; in vivo; innovation; insight; intestinal epithelium; knock-down; microbial; military veteran; mortality; neutralizing antibody; novel; response; single-cell RNA sequencing; small hairpin RNA; transcriptome; vaccination strategy; vaccine development

Summary Infectious diseases, including Hepatitis C (HCV) and HIV, remain important health problems among Veterans. Development of vaccines for infectious diseases is therefore a key priority. Immunologic memory is a cardinal feature of adaptive immunity and an important goal of vaccination strategies. Traditional vaccination strategies are very effective at generating neutralizing antibodies, but not effective T cell memory. A key reason for the current lack of effective vaccines against many infectious diseases is that we do not yet know how to make vaccines that generate robust T cell memory. Thus, a fundamental understanding of how memory cells are formed is a crucial first step in rational vaccine design for infectious diseases.

摘要 包括丙型肝炎和艾滋病毒在内的传染病仍然是退伍军人的重要健康问题。 因此，开发传染病疫苗是一个关键的优先事项。免疫记忆是最重要的 获得性免疫的特点和疫苗接种策略的一个重要目标。传统的疫苗接种策略 在产生中和抗体方面非常有效，但不能有效地记忆T细胞。一个关键原因是 目前缺乏针对许多传染病的有效疫苗是我们还不知道如何制造 产生强大T细胞记忆的疫苗。因此，对存储单元是如何 形成是合理设计传染病疫苗的关键第一步。