Role of proteasome activity in adaptive immunity

蛋白酶体活性在适应性免疫中的作用

• 批准号: 10025999
• 负责人: John T Chang
• 金额: $ 5.33万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10025999
• 关键词: Bacteria; Biomedical Research; Cause of Death; Cells; Communicable Diseases; Development; Goals; Immune system; Immunologic Memory; Infection; Lymphocyte; Process; Research; Role; T memory cell; T-Lymphocyte; Testing; Vaccines; Virus; adaptive immunity; improved; mortality; multicatalytic endopeptidase complex; neutralizing antibody; novel vaccines; vaccination strategy; vaccine efficacy

Project Summary Mortality from infectious diseases remains a leading cause of death worldwide, making the development of new vaccines an important priority of biomedical research. Immunologic memory is a cardinal feature of adaptive immunity and an important goal of vaccination strategies. Traditional vaccination strategies are very effective at generating neutralizing antibodies against bacteria and viruses. However, a vaccine capable of generating robust T lymphocyte memory is still beyond our research, due, in part, to an incomplete understanding of the basis of lymphocyte fate specification. In this study, we propose to study the role of proteasome degradation activity in controlling this process.

项目摘要 传染病死亡率仍然是全世界死亡的主要原因， 新疫苗的开发是生物医学研究的一个重要优先事项。免疫 记忆是适应性免疫的一个重要特征，也是疫苗接种的一个重要目标 战略布局传统的疫苗接种策略在产生中和作用方面非常有效 抗细菌和病毒的抗体。然而，一种能够产生强大T细胞的疫苗， 淋巴细胞记忆仍然超出了我们的研究范围，部分原因是我们对淋巴细胞记忆的理解不完全。 淋巴细胞命运特化的基础。在这项研究中，我们建议研究的作用 蛋白酶体降解活性控制这一过程。