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Role of proteasome activity in adaptive immunity

Role of proteasome activity in adaptive immunity
蛋白酶体活性在适应性免疫中的作用
批准号：
10025999
负责人：
John T Chang
金额：
$5.33万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
项目状态：
已结题
起止时间：
2017-12-01 至 2022-11-30
来源：
https://reporter.nih.gov/project-details/10025999
关键词：
BacteriaBiomedical ResearchCause of DeathCellsCommunicable DiseasesDevelopmentGoalsImmune systemImmunologic MemoryInfectionLymphocyteProcessResearchRoleT memory cellT-LymphocyteTestingVaccinesVirusadaptive immunityimprovedmortalitymulticatalytic endopeptidase complexneutralizing antibodynovel vaccinesvaccination strategyvaccine efficacy

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英文摘要
Project Summary Mortality from infectious diseases remains a leading cause of death worldwide, making the development of new vaccines an important priority of biomedical research. Immunologic memory is a cardinal feature of adaptive immunity and an important goal of vaccination strategies. Traditional vaccination strategies are very effective at generating neutralizing antibodies against bacteria and viruses. However, a vaccine capable of generating robust T lymphocyte memory is still beyond our research, due, in part, to an incomplete understanding of the basis of lymphocyte fate specification. In this study, we propose to study the role of proteasome degradation activity in controlling this process.
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T cell subsets in inflammatory bowel disease
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  • 财政年份：
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  • 依托单位：
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T cell subsets in inflammatory bowel disease
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Transcriptional regulation of T cell immunity
  • 批准号：
    10341041
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    $0.0万
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    2021
  • 负责人：
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    VA SAN DIEGO HEALTHCARE SYSTEM
Transcriptional regulation of T cell immunity
  • 批准号：
    10008141
  • 项目类别：
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  • 财政年份：
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  • 负责人：
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