Role of proteasome activity in adaptive immunity

蛋白酶体活性在适应性免疫中的作用

• 批准号: 10066260
• 负责人: John T Chang
• 金额: $ 49.6万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10066260
• 关键词: 26S proteasome; Applications Grants; Bacteria; Biological; Biomedical Research; CD8-Positive T-Lymphocytes; Caspase; Catalytic Domain; Cause of Death; Cell division; Cells; Communicable Diseases; Data; Daughter; Deubiquitinating Enzyme; Development; Excision; Generations; Goals; Immune system; Immunologic Memory; Infection; Inherited; Lead; Link; Lymphocyte; Lymphocyte Subset; Memory; Metabolic; Mitotic; Nucleosome Core Particle; Oxidative Phosphorylation; Play; Pluripotent Stem Cells; Process; Protein Complex Subunit; Publishing; Regulation; Research; Role; Signal Transduction; Specific qualifier value; T cell differentiation; T memory cell; T-Cell Receptor; T-Lymphocyte; Testing; Trypsin; Ubiquitin; Vaccine Design; Vaccines; Virus; Work; adaptive immunity; aerobic glycolysis; base; cancer stem cell; cell type; chymotrypsin; cytokine; daughter cell; effector T cell; experience; human embryonic stem cell; improved; in vivo; insight; microbial; mortality; multicatalytic endopeptidase complex; neutralizing antibody; novel; novel vaccines; particle; protein degradation; response; segregation; vaccination strategy; vaccine access; vaccine efficacy

Project Summary Mortality from infectious diseases remains a leading cause of death worldwide, making the development of new vaccines an important priority of biomedical research. Immunologic memory is a cardinal feature of adaptive immunity and an important goal of vaccination strategies. Traditional vaccination strategies are very effective at generating neutralizing antibodies against bacteria and viruses. However, a vaccine capable of generating robust T lymphocyte memory is still beyond our research, due, in part, to an incomplete understanding of how lymphocyte fates are specified. In this grant application, we propose to study the role of proteasome degradation activity in controlling this process.

项目摘要 传染病的死亡率仍然是全世界的主要死因， 使新疫苗的开发成为生物医学研究的重要优先事项。 免疫记忆是获得性免疫的一个重要特征，也是免疫学研究的一个重要目标。 疫苗接种策略。传统的疫苗接种策略非常有效， 中和细菌和病毒的抗体。然而，一种能够 产生强大的T淋巴细胞记忆仍然超出了我们的研究，部分原因是， 不完全理解淋巴细胞的命运是如何指定的。在这份赠款中， 应用，我们建议研究蛋白酶体降解活性在 控制这个过程。