T cell subsets in inflammatory bowel disease

炎症性肠病中的 T 细胞亚群

• 批准号: 10569030
• 负责人: John T Chang
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10569030
• 关键词: Abscess; Address; Affect; Autoimmune Diseases; Biological Response Modifier Therapy; CD8-Positive T-Lymphocytes; CRISPR/Cas technology; Categories; Cell model; Cells; Chronic; Crohn' s disease; Cytometry; Development; Disease; Disease remission; Exhibits; Failure; Financial Hardship; Fistula; Functional disorder; Gastrointestinal tract structure; Genetic; Health; Human; IL17 gene; Immune; Immune system; Immunity; Individual; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Intestinal Diseases; Intestines; Knock-out; Knowledge; Location; Longevity; Mediating; Memory; Modeling; Molecular; Morbidity - disease rate; Multiple Sclerosis; Nature; Pathogenesis; Pathogenicity; Patients; Pharmaceutical Preparations; Pharmacotherapy; Play; Process; Protein Analysis; Rectum; Refractory; Regulation; Relapse; Reporting; Rheumatoid Arthritis; Risk; Role; Systemic Lupus Erythematosus; T cell differentiation; T memory cell; T-Lymphocyte Subsets; Thyroiditis; Time; Tissues; Ulcerative Colitis; United States; Veterans; Veterans Health Administration; Work; base editing; biomarker identification; cytokine; gut inflammation; immunogenicity; military veteran; mortality; mouse model; new therapeutic target; novel therapeutic intervention; pathogenic microbe; protein profiling; rectal; single-cell RNA sequencing; transcription factor; transcriptomic profiling

Summary The inflammatory bowel diseases (IBD) are chronic, incurable conditions that contribute to significant morbidity and mortality in the Veteran population. Current therapies are effective long-term in only ~25% of patients with IBD, suggesting that as yet unknown immune cell subsets may be involved in the initial development and relapsing-remitting nature of IBD. We propose to elucidate T cell subsets that may play a role in the pathophysiology of IBD; this work may ultimately lead to new therapeutic targets for IBD.

总结 炎症性肠病（IBD）是一种慢性、不可治愈的疾病， 以及退伍军人的死亡率目前的治疗方法仅对约25%的患者长期有效， IBD，这表明迄今未知的免疫细胞亚群可能参与了最初的发展， IBD的复发-缓解性质。我们建议阐明T细胞亚群，可能发挥作用，在 IBD的病理生理学;这项工作可能最终导致IBD的新治疗靶点。