Chemically Precise Framework Materials as a Modular Platform Technology for Electroanalysis

工程组织为改善患者的健康和生活质量带来了巨大的希望 遭受创伤、疾病或器官衰竭。实现组织工程的全部效益 需要提高对体内平衡、代谢、炎症和 工程组织中的营养物质运输，加上可靠和综合的质量控制， 制造过程。由于是模块化的，便携式的，能够实时操作 环境，以及适合于非侵入性和无标签的格式，化学品 基于电分析的质量控制为这一挑战提供了一种合理的解决方案。然而，在这方面， 当前的电分析装置不允许选择性的原位连续化学监测 和报道在封闭的生物反应器内的工程化3D组织支架中的性能。 研究工程组织的化学过程需要全新的传感技术 具有改进的化学敏感性、选择性、化学稳定性的材料， 与3D组织支架直接整合。 本研究的总体目标是开发导电金属有机框架 本发明涉及作为多功能传感材料的MOFs和共价有机框架（COFs）， 在电分析中的潜在用途。化学检测的拟议技术方法 提供了前所未有的能力，以产生原子精确的电子材料和设备， 化学可调的电分析性能。此MIRA应用程序利用自下而上 合成和自组装以开发灵敏和选择性非酶多孔工作 用于气体传递物（CO、NO、H2S）、营养物和代谢物（葡萄糖和乳酸盐）的电极， 和神经化学物质（抗坏血酸、尿酸、多巴胺和血清素）。 该研究计划采用多学科方法，包括化学合成， 光谱表征、设备集成和电分析，以实现三个 分子工程中化学控制的分级水平 化学检测：（1）通过溶剂热反应在原子水平上控制主客体相互作用 合成和自组装;（2）通过表面形态调整进行纳米尺度控制 电催化;（3）固态、多孔和多孔材料中电化学界面的外延控制， 灵活的设备。从这项工作中出现的概念和技术进步将作为一个 车辆发展提出的材料成为未来电分析的新组件 在组织工程、生物医学分析和患者治疗领域具有变革潜力的设备， 以移动的医疗保健为中心。

Engineered tissue holds tremendous promise for improving health and quality of life of patients suffering from trauma, illness, or organ failure. Realizing the full benefits in tissue engineering requires improved fundamental understanding of homeostasis, metabolism, inflammation, and nutrient transport in engineered tissue, coupled with reliable and integrated quality control during the manufacturing process. By virtue of being modular, portable, capable of operating in real-time environments, as well as being amenable to non-invasive and label-free formats, a chemical quality control based on electroanalysis offers one plausible solution to this challenge. However, current electroanalytical devices do not allow for selective in-situ continuous chemical monitoring and reporting of performance in engineered 3D tissue scaffolds within enclosed bioreactors. Enabling the study of chemical processes of engineered tissue requires radically new sensing materials with improved chemical sensitivity, selectivity, chemical stability capable of straightforward integration with 3D tissue scaffolds. The overarching goal of this research is to develop conductive metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) as multifunctional sensing materials with broad potential utility in electroanalysis. The proposed technological approach to chemical detection offers unprecedented ability to generate atomically-precise electronic materials and devices with chemically-tunable electroanalytical performance. This MIRA application leverages bottom-up synthesis and self-assembly to develop sensitive and selective non-enzymatic porous working electrodes for gasotransmitters (CO, NO, H2S), nutrients and metabolites (glucose and lactate), and neurochemicals (ascorbic acid, uric acid, dopamine, and serotonin). The research plan implements a multidisciplinary approach comprising chemical synthesis, spectroscopic characterization, device integration, and electroanalysis to achieve three hierarchical levels of chemical control in molecular engineering of framework materials for chemical detection: (1) Atomic-level control of host-guest interactions through solvothermal synthesis and self-assembly; (2) Nanoscale control through morphological tuning of surface electrocatalysis; (3) Epitaxial control of electrochemical interfaces within solid-state, porous, and flexible devices. Conceptual and technological advances emerging from this work will serve as a vehicle to develop the proposed materials into novel components of future electroanalytical devices with transformative potential in tissue engineering, biomedical analysis, and patient- centered mobile healthcare.