Chemically Precise Framework Materials as a Modular Platform Technology for Electroanalysis

化学精确的框架材料作为电分析的模块化平台技术

• 批准号: 10263177
• 负责人: Katherine Andrea Mirica
• 金额: $ 40.7万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263177
• 关键词: 3-Dimensional; Ascorbic Acid; Bioreactors; Chemicals; Coupled; Detection; Development; Devices; Dopamine; Electrodes; Electronics; Engineering; Environment; Future; Glucose; Goals; Health; Healthcare; Homeostasis; In Situ; Inflammation; Label; Metabolism; Metals; Molecular; Monitor; Morphology; Nutrient; Organ failure; Patients; Performance; Physiological; Process; Quality Control; Quality of life; Reporting; Research; Serotonin; Surface; System; Technology; Time; Tissue Engineering; Transducers; Trauma; Uric Acid; Work; base; chemical stability; chemical synthesis; design; flexibility; improved; interdisciplinary approach; manufacturing process; nanoscale; neurochemistry; novel; patient oriented; portability; scaffold; self assembly; solid state; tissue support frame; wearable device

Engineered tissue holds tremendous promise for improving health and quality of life of patients suffering from trauma, illness, or organ failure. Realizing the full benefits in tissue engineering requires improved fundamental understanding of homeostasis, metabolism, inflammation, and nutrient transport in engineered tissue, coupled with reliable and integrated quality control during the manufacturing process. By virtue of being modular, portable, capable of operating in real-time environments, as well as being amenable to non-invasive and label-free formats, a chemical quality control based on electroanalysis offers one plausible solution to this challenge. However, current electroanalytical devices do not allow for selective in-situ continuous chemical monitoring and reporting of performance in engineered 3D tissue scaffolds within enclosed bioreactors. Enabling the study of chemical processes of engineered tissue requires radically new sensing materials with improved chemical sensitivity, selectivity, chemical stability capable of straightforward integration with 3D tissue scaffolds. The overarching goal of this research is to develop conductive metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) as multifunctional sensing materials with broad potential utility in electroanalysis. The proposed technological approach to chemical detection offers unprecedented ability to generate atomically-precise electronic materials and devices with chemically-tunable electroanalytical performance. This MIRA application leverages bottom-up synthesis and self-assembly to develop sensitive and selective non-enzymatic porous working electrodes for gasotransmitters (CO, NO, H2S), nutrients and metabolites (glucose and lactate), and neurochemicals (ascorbic acid, uric acid, dopamine, and serotonin). The research plan implements a multidisciplinary approach comprising chemical synthesis, spectroscopic characterization, device integration, and electroanalysis to achieve three hierarchical levels of chemical control in molecular engineering of framework materials for chemical detection: (1) Atomic-level control of host-guest interactions through solvothermal synthesis and self-assembly; (2) Nanoscale control through morphological tuning of surface electrocatalysis; (3) Epitaxial control of electrochemical interfaces within solid-state, porous, and flexible devices. Conceptual and technological advances emerging from this work will serve as a vehicle to develop the proposed materials into novel components of future electroanalytical devices with transformative potential in tissue engineering, biomedical analysis, and patient- centered mobile healthcare.

工程组织为改善患者的健康和生活质量带来了巨大的希望 创伤的遭受创伤、疾病或器官衰竭的实现组织工程的最大效益 需要更好地了解动态平衡、代谢、炎症和 在工程组织中的营养传输，加上可靠和综合的质量控制 制造过程。其优点是模块化、便携、能够实时操作 环境，以及对非侵入性和无标签格式的服从，一种化学物质 基于电分析的质量控制为这一挑战提供了一个看似合理的解决方案。然而， 目前的电分析设备不允许选择性的现场连续化学监测 以及封闭式生物反应器内的工程化3D组织支架的性能报告。 研究工程组织的化学过程需要全新的传感技术 具有改进的化学敏感性、选择性、化学稳定性的材料能够 与3D组织支架直接集成。 本研究的首要目标是开发导电金属有机骨架。 (MOF)和共价有机骨架(COF)作为多功能传感材料具有广泛的应用前景 在电分析中的潜在用途。建议的化学检测技术途径 提供前所未有的能力来生产原子精确的电子材料和设备 化学可调的电分析性能。此Mira应用程序利用自下而上 合成和自组装发展灵敏和选择性的非酶多孔工作 气体发射器(CO、NO、H_2S)、营养素和代谢物(葡萄糖和乳酸)的电极， 和神经化学物质(抗坏血酸、尿酸、多巴胺和5-羟色胺)。 该研究计划实施了包括化学合成在内的多学科方法， 光谱表征、设备集成和电分析实现三个目标 骨架材料分子工程中的化学控制等级 化学检测：(1)通过溶剂热对主客体相互作用进行原子水平控制 合成与自组装；(2)表面形态调控的纳米控制 电催化；(3)固态、多孔和非晶态中电化学界面的外延控制。 灵活的设备。这项工作产生的概念和技术进步将成为 将建议的材料开发为未来电分析的新组件的工具 在组织工程、生物医学分析和患者方面具有变革潜力的设备- 以移动医疗为中心。