Shared Resource Core
共享资源核心
基本信息
- 批准号:10007612
- 负责人:
- 金额:$ 14.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-28 至 2021-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressBasic ScienceBehavioral ResearchBioinformaticsBiomedical ResearchBostonCancer CenterCellsClinicalClinical SciencesCodeCollaborationsCollectionCommunitiesComplexConsultationsDana-Farber Cancer InstituteDataData AnalysesData SetDatabasesDevelopmentEducational workshopExperimental DesignsFacultyFocus GroupsFosteringFutureGenerationsGenomicsHCT116 CellsIncubatorsInfrastructureInfrastructure ActivitiesInterviewLaboratoriesLanguageMalignant Epithelial CellMassachusettsMeasuresMediatingMethodologyMissionMolecularParticipantPoint MutationPopulationPopulation AnalysisPopulation SciencesPostdoctoral FellowProceduresQuantitative Reverse Transcriptase PCRResearchResearch ActivityResearch DesignResearch MethodologyResearch PersonnelResearch Project GrantsResearch SupportResource SharingSNP genotypingSeriesService provisionServicesSiteSmall Interfering RNASocietiesStatistical Data InterpretationStatistical MethodsSurveysSystemTechnologyTrainingTraining ActivityUniversitiesWorkanticancer researchbasecancer health disparitycatalystdata acquisitiondesignexomeindividual patientindustry partnerinsertion/deletion mutationinstrumentationknock-downmembermutantnano-stringnext generation sequencingpersonalized cancer therapysocialsoundstudent trainingsuccesstranslational cancer researchtranslational impact
项目摘要
Summary: Proper study design, data generation, and analysis of complex datasets drawn from population-
and molecular-level studies are crucial for the advancement of population and basic science research. To
facilitate this, the Partnership proposes to provide the necessary infrastructure for these activities through the
Research Design and Analysis Core (RDAC) and the Genomics Core (GC), collectively described as the
Shared Resource Core (SRC). The RDAC aims to 1) support quantitative activities involving collection of
original data at different levels – from individuals/patients to organizations and communities; 2) provide training
in the design, implementation and analysis of population science research to U54 participants and members of
the UMass Boston and DF/HCC communities at all academic levels; 3) assist with appropriate experimental
design and statistical analysis of data acquired from laboratory- or clinically-based studies; and 4) serve as a
catalyst for new collaborations between investigators at UMass Boston and DF/HCC partner sites. The RDAC
builds upon and synergizes existing Centers/Cores at UMass Boston and DF/HCC. Similarly, the Partnership
has created the Genomics Core by leveraging genomics services offered by the newly created Center for
Personalized Cancer Therapy (CPCT) at UMass Boston. The GC uses state-of-the-art instrumentation and
data analysis methodologies and aims to provide U54 partners and investigators with accessible research
support platforms to facilitate high-impact genomics-based translational cancer research and basic science
research. Together, the RDAC and GC Shared Resource Core constitutes the framework to provide population
and genomics-based basic science studies with proper study design, data acquisition, and data analysis
across a broad spectrum of 'Cells to Society' research. The SRC will be utilized by all proposed research
projects in this application (see Pilot and Full Project sections). Specifically, the Schrag/Lindsay population
science project will utilize the RDAC to provide consultation in survey development and oversight of necessary
pretesting of English and Spanish-language survey measures, database development, data entry and data
analysis. Dr. Lindsay and the RDAC will work together to provide U54 trainees with intensive training in focus
group procedures, e.g., creation of an interview guide, focus group moderation and qualitative analysis, and
qualitative data coding. The RDAC will also be utilized by the Kulkarni/Zarringhalam/Pandolfi basic science
project to provide assistance with quantitation and statistical analysis of the isogenic WT and DICER mutant
HCT116 carcinoma cell studies and siRNA-mediated ceRNA knock-down studies. The GC will be utilized by
the Siegfried/Sweeney/Van Allen basic science project to generate sequencing data and provide bioinformatics
analysis of sequencing data to call somatic point mutations, short insertion/deletions, and copy number
changes from the exomes. Going forward, the SRC will be heavily used by Partnership incubator projects to
complete preliminary studies towards consideration of support as future U54 Pilot or Full Projects.
摘要:适当的研究设计、数据生成和从人口中提取的复杂数据集的分析
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jill A. Macoska其他文献
Fluorescence In Situ Hybridization (FISH) to Metaphase and Interphase Chromosomes.
中期和间期染色体荧光原位杂交 (FISH)。
- DOI:
10.1385/1-59259-144-2:101 - 发表时间:
2001 - 期刊:
- 影响因子:0
- 作者:
Jill A. Macoska - 通讯作者:
Jill A. Macoska
Jill A. Macoska的其他文献
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{{ truncateString('Jill A. Macoska', 18)}}的其他基金
Persistence of an IL-4/IL-13 autocrine loop promotes fibrosis-mediated urinary voiding dysfunction
IL-4/IL-13 自分泌环的持续存在促进纤维化介导的尿排尿功能障碍
- 批准号:
10022319 - 财政年份:2014
- 资助金额:
$ 14.88万 - 项目类别:
Persistence of an IL-4/IL-13 autocrine loop promotes fibrosis-mediated urinary voiding dysfunction
IL-4/IL-13 自分泌环的持续存在促进纤维化介导的尿排尿功能障碍
- 批准号:
10700930 - 财政年份:2014
- 资助金额:
$ 14.88万 - 项目类别:
Persistence of an IL-4/IL-13 autocrine loop promotes fibrosis-mediated urinary voiding dysfunction
IL-4/IL-13 自分泌环的持续存在促进纤维化介导的尿排尿功能障碍
- 批准号:
10264807 - 财政年份:2014
- 资助金额:
$ 14.88万 - 项目类别:
Fibrosis-Associated Urinary Gene Transcripts for LUTS Detection and Treatment
用于 LUTS 检测和治疗的纤维化相关尿液基因转录
- 批准号:
8738645 - 财政年份:2013
- 资助金额:
$ 14.88万 - 项目类别:
Fibrosis-Associated Urinary Gene Transcripts for LUTS Detection and Treatment
用于 LUTS 检测和治疗的纤维化相关尿液基因转录
- 批准号:
8486921 - 财政年份:2013
- 资助金额:
$ 14.88万 - 项目类别:
Society for Basic Urologic Research Fall Symposium 2012
基础泌尿学研究学会 2012 年秋季研讨会
- 批准号:
8453755 - 财政年份:2012
- 资助金额:
$ 14.88万 - 项目类别:
Role of Prostatic Fibrosis in BPH/LUTS Development & Symptomology
前列腺纤维化在 BPH/LUTS 发展中的作用
- 批准号:
8150959 - 财政年份:2010
- 资助金额:
$ 14.88万 - 项目类别:
Role of Prostatic Fibrosis in BPH/LUTS Development & Symptomology
前列腺纤维化在 BPH/LUTS 发展中的作用
- 批准号:
8049846 - 财政年份:2010
- 资助金额:
$ 14.88万 - 项目类别:
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