Developmental Research Program

发展研究计划

• 批准号: 10005255
• 负责人: RICHARD ALLEN SCRIBNER
• 金额: $ 12.07万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-19 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005255
• 关键词: Address; Affect; Applications Grants; Basic Science; Biological; Cancer Center; Characteristics; Clinical; Clinical Data; Clinical Trials; Colorectal Cancer; Communities; Core Facility; Data; Development; Endometrial Carcinoma; Ensure; Extramural Activities; Familial prostate cancer; Financial Support; Fostering; Funding; Future; Genetic study; Genomics; Goals; Grant; Human; Immunologics; Inflammatory; Institution; Interdisciplinary Study; Intervention; Intervention Studies; Knowledge; Louisiana; Malignant Neoplasms; Malignant neoplasm of liver; Minority; Monitor; Obesity; Patients; Population; Population Intervention; Population Sciences; Population Study; Probability; Process; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Role; Sampling; Translating; Work; biological research; cancer health disparity; cohesion; flexibility; genomic signature; health disparity; innovation; knowledge integration; medical schools; multidisciplinary; novel; pre-clinical; pre-clinical research; programs; social health determinants; success; triple-negative invasive breast carcinoma; tumor; tumor-immune system interactions

ABSTRACT The Developmental Research Program (DRP) main goal is to select and support highly promising and innovative Pilot Research Projects studying the genetic, biological and/or social determinants of Health Disparities in triple-negative breast cancers (TNBC) and other malignancies that disproportionately affect minority patients of Louisiana. Pilot Research Projects (PRP) will develop the preliminary data to support competitive Research Projects for a future SPORE application. These may include additional basic research concepts using patient samples, clinical interventions in the form of clinical trials or population studies. These Pilot Research Projects will expand the scope and depth of research on TNBC, and other malignancies such as liver cancer, endometrial cancer, familial prostate cancer and colorectal cancer that represent major health disparities in our community. Given that part of our efforts is aimed at understanding the role of genomic signatures and inflammatory features in TNBC, we will encourage Pilot Research Projects that address similar mechanisms in other cancers. High quality projects in these fields would create horizontal and vertical integration of the knowledge and resources of Projects 1 and 2 with the selected Pilot Research Projects. To achieve its goal, the DRP will provide direct and significant financial support for the PRP and provide the investigators with access to the expertise and resources of the Shared Resource Core facilities supported by this P20 planning grant, and other Core facilities available at the Stanley Scott Cancer Center (LSU CC- NO) and at our partner institutions. The DRP will select and fund a minimum of four (4) PRP over the 36 months addressing Cancer and Health Disparities. At the completion of this P20 planning grant, we expect that the PRPs will have developed the necessary data to evolve into competitive Research Projects that will form part of the future SPORE application. The PRP's will help establish a pipeline of highly competitive research projects to ensure the long-term sustainability of research in Cancer Health Disparities in Louisiana.

摘要 发展研究计划(DRP)的主要目标是选择和支持有前途的 研究健康的遗传、生物和/或社会决定因素的创新性试点研究项目 三阴性乳腺癌(TNBC)和其他影响不成比例的恶性肿瘤的差异 路易斯安那州的少数族裔患者。试点研究项目(PRP)将开发初步数据以支持 未来孢子应用的竞争性研究项目。这些可能包括额外的基础研究。 使用患者样本的概念，临床试验或人口研究形式的临床干预。这些 试点研究项目将扩大对TNBC等其他恶性肿瘤的研究范围和深度 如代表主要健康的肝癌、子宫内膜癌、家族性前列腺癌和结直肠癌 我们社区中的不平等。鉴于我们努力的一部分是为了了解基因组的作用 在TNBC中的签名和煽动性特征，我们将鼓励解决类似问题的试点研究项目 其他癌症的机制。这些领域的高质量项目将创造水平和垂直 将项目1和2的知识和资源与选定的试点研究项目相结合。至 为实现其目标，民主党将向革命制度党提供直接和重大的财政支持，并提供 调查员有权使用由以下机构支持的共享资源核心设施的专门知识和资源 此P20规划拨款，以及斯坦利·斯科特癌症中心(路易斯安那州立大学CC-NO)提供的其他核心设施 在我们的伙伴机构。DRP将在36个月内选择和资助至少四(4)个PRP 解决癌症和健康差距问题。在这笔P20规划拨款完成后，我们预计 PRPS将开发必要的数据，以演变为竞争性研究项目，这些项目将成为 对未来孢子应用的展望。PRP将帮助建立一条竞争激烈的研究渠道 确保路易斯安那州癌症健康差异研究的长期可持续性的项目。