ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES

自发性和药物诱发的系统性红斑狼疮及其他疾病中的抗核抗体

• 批准号: 3961228
• 负责人: A D STEINBERG
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3961228
• 关键词: B lymphocyte; DNA; antiantibody; antibody specificity; antinuclear autoantibody; autoimmune disorder; complement fixation tests; connective tissue disorder diagnosis; cytosine; estradiol; gender difference; genetic strain; guanine; hemagglutination test; hormone regulation /control mechanism; human subject; hybridomas; immune complex; immunodiffusion; immunogenetics; immunoglobulin genes; immunotherapy; isoantibody; leukocyte activation /transformation; leukocytes; molecular pathology; molecular weight; monoclonal antibody; orphan disease /drug; radioimmunoassay; radiotracer; sex chromosomes; sex hormones; systemic lupus erythematosus; testosterone; tissue /cell culture

Antibodies to nucleic acids are important diagnostically and pathogenetically in systemic lupus. Patients with active SLE have an increase in DNA in immune complexes. Such DNA is enriched in guanine (G) and cytosine (C). Low molecular weight DNA enriched in G-C is released from SLE leukocytes. This DNA may be important in the pathogenesis of SLE. Genes favoring the production of anti-DNA may include those which lead to the release of immunogenic DNA. In mice a subset of B cells is responsible for anti-DNA production. In NZB mice, B cells can transfer anti-DNA to congenic NZB.xid recipients. This transfer is prevented by treating either donors animals or recipients with anti-Ia antibodies. Similar approaches to human disease are being sought.

核酸抗体在诊断上很重要，而且 在系统性红斑狼疮中致病。活动期SLE患者有一种 免疫复合体中DNA的增加。这种DNA富含鸟嘌呤(G) 和胞嘧啶(C)。富含G-C的低分子DNA被释放 来自系统性红斑狼疮的白细胞。这种DNA可能在霍乱的发病机制中起重要作用。 SLE。有利于产生抗DNA的基因可能包括 导致免疫原性DNA的释放。 在小鼠中，B细胞的一个亚群负责产生抗DNA。在新西兰 小鼠，B细胞可以将抗DNA转移到同基因的NZB.xid受体。这 通过对捐赠者动物或接受者进行治疗来防止移植 抗Ia抗体。人们正在寻求类似的方法来治疗人类疾病。