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ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES

ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES
自发性和药物诱发的系统性红斑狼疮及其他疾病中的抗核抗体
批准号：
3961228
负责人：
A D STEINBERG
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3961228
关键词：
B lymphocyte DNA antiantibody antibody specificity antinuclear autoantibody autoimmune disorder complement fixation tests connective tissue disorder diagnosis cytosine estradiol gender difference genetic strain guanine hemagglutination test hormone regulation /control mechanism human subject hybridomas immune complex immunodiffusion immunogenetics immunoglobulin genes immunotherapy isoantibody leukocyte activation /transformation leukocytes molecular pathology molecular weight monoclonal antibody orphan disease /drug radioimmunoassay radiotracer sex chromosomes sex hormones systemic lupus erythematosus testosterone tissue /cell culture

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英文摘要
Antibodies to nucleic acids are important diagnostically and pathogenetically in systemic lupus. Patients with active SLE have an increase in DNA in immune complexes. Such DNA is enriched in guanine (G) and cytosine (C). Low molecular weight DNA enriched in G-C is released from SLE leukocytes. This DNA may be important in the pathogenesis of SLE. Genes favoring the production of anti-DNA may include those which lead to the release of immunogenic DNA. In mice a subset of B cells is responsible for anti-DNA production. In NZB mice, B cells can transfer anti-DNA to congenic NZB.xid recipients. This transfer is prevented by treating either donors animals or recipients with anti-Ia antibodies. Similar approaches to human disease are being sought.
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ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES
PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
VARIOUS CYTOTOXIC DRUG PROGRAMS IN DIFFUSE LUPUS NEPHRITIS
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