ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES

核酸抗体在诊断上很重要，而且 在系统性红斑狼疮中致病。活动期系统性红斑狼疮患者 免疫复合体中的DNA含量增加。这样的DNA是 富含鸟嘌呤(G)和胞嘧啶(C)。低分子量 富含G-C的DNA从SLE白细胞中释放出来。这 DNA可能在SLE的发病机制中起重要作用。基因 支持生产抗DNA的药物可能包括 导致免疫原性DNA的释放。 在小鼠中，B细胞的一个亚群负责抗DNA 制作。在NZB小鼠中，B细胞可以将抗DNA转移到 同基因NZB.xid受体。这种转移受到以下因素的阻止 用抗Ia抗体治疗供体动物或受体 抗体。类似的治疗人类疾病的方法正在出现 被追寻。 在自身免疫小鼠中，多克隆B细胞激活，而不是 特异性免疫，是抗DNA的主要贡献者 过度生产。系统性红斑狼疮患者的曲目更多 不同于老鼠。区别在于免疫球蛋白，而不是免疫球蛋白。 自身抗体。在这些个人中，特定的免疫接种或 交叉反应免疫也可能在以下方面发挥关键作用 自身抗体的产生。

Antibodies to nucleic acids are important diagnostically and pathogenetically in systemic lupus. Patients with active SLE have an increase in DNA in immune complexes. Such DNA is enriched in guanine (G) and cytosine (C). Low molecular weight DNA enriched in G-C is released from SLE leukocytes. This DNA may be important in the pathogenesis of SLE. Genes favoring the production of anti-DNA may include those which lead to the release of immunogenic DNA. In mice a subset of B cells is responsible for anti-DNA production. In NZB mice, B cells can transfer anti-DNA to congenic NZB.xid recipients. This transfer is prevented by treating either donors animals or recipients with anti-Ia antibodies. Similar approaches to human disease are being sought. In autoimmune mice, polyclonal B cell activation, rather than specific immunization, is the major contributor to anti-DNA hyperproduction. Patients with SLE have greater repertoire differences than mice. The differences are in IgG but not IgM autoantibodies. In these individuals specific immunization or cross-reactive immunization may also play a critical role in autoantibody production.