课题基金 / 基金详情

ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES

ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES
自发性和药物诱发的系统性红斑狼疮及其他疾病中的抗核抗体
批准号：
4689946
负责人：
A D STEINBERG
金额：
$0.0万
依托单位：
NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4689946
关键词：
antibody specificity antinuclear autoantibody autoimmune disorder complement fixation tests connective tissue disorder diagnosis estradiol gender difference genetic strain hemagglutination test hormone regulation /control mechanism human subject hybridomas immunodiffusion immunogenetics immunoglobulin genes monoclonal antibody orphan disease /drug radioimmunoassay radiotracer sex chromosomes sex hormones systemic lupus erythematosus testosterone tissue /cell culture

项目摘要

项目成果

A D STEINBERG的其他基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Antibodies to nucleic acids are important diagnostically and pathogenetically in systemic lupus. Patients with active SLE have an increase in DNA in immune complexes. Such DNA is enriched in guanine (G) and cytosine (C). Low molecular weight DNA enriched in G-C is released from SLE leukocytes. This DNA may be important in the pathogenesis of SLE. Genes favoring the production of anti-DNA may include those which lead to the release of immunogenic DNA. In mice a subset of B cells is responsible for anti-DNA production. A similar human subset is being sought. If found, an attempt could be made to preferentially eliminate such B cells.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
VARIOUS CYTOTOXIC DRUG PROGRAMS IN DIFFUSE LUPUS NEPHRITIS
IMMUNE ABNORMALITIES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS