ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES

自发性和药物诱发的系统性红斑狼疮及其他疾病中的抗核抗体

• 批准号: 4689946
• 负责人: A D STEINBERG
• 金额: --
• 依托单位: NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4689946
• 关键词: antibody specificity; antinuclear autoantibody; autoimmune disorder; complement fixation tests; connective tissue disorder diagnosis; estradiol; gender difference; genetic strain; hemagglutination test; hormone regulation /control mechanism; human subject; hybridomas; immunodiffusion; immunogenetics; immunoglobulin genes; monoclonal antibody; orphan disease /drug; radioimmunoassay; radiotracer; sex chromosomes; sex hormones; systemic lupus erythematosus; testosterone; tissue /cell culture

Antibodies to nucleic acids are important diagnostically and pathogenetically in systemic lupus. Patients with active SLE have an increase in DNA in immune complexes. Such DNA is enriched in guanine (G) and cytosine (C). Low molecular weight DNA enriched in G-C is released from SLE leukocytes. This DNA may be important in the pathogenesis of SLE. Genes favoring the production of anti-DNA may include those which lead to the release of immunogenic DNA. In mice a subset of B cells is responsible for anti-DNA production. A similar human subset is being sought. If found, an attempt could be made to preferentially eliminate such B cells.

核酸抗体在诊断上是重要的， 系统性狼疮的发病机制 活动性SLE患者 免疫复合物中DNA的增加。 这种DNA富含鸟嘌呤（G） 和胞嘧啶（C）。 释放富含G-C的低分子量DNA SLE白细胞。 这种DNA可能是重要的发病机制， SLE。 有利于产生抗DNA的基因可能包括那些 导致免疫原性DNA的释放 在小鼠中，B细胞的亚群负责抗DNA的产生。 一 正在寻找类似的人类子集。 如果被发现， 以优先消除这种B细胞。