Toward portable microchannel artificial lungs for veteran rehabilitation

 描述(由申请人提供)： 这一技术开发项目的长期目标是通过开发第一个真正便携的、生物兼容的、能够短期和长期呼吸支持的人工肺来改善患有肺病的退伍军人的康复。目前的人工肺最近已被用于肺部疾病患者的康复；然而，需要在气体交换、生物相容性和便携性方面取得重大进展，才能充分发挥其潜力。微通道人工肺有望实现一种真正便携的人工肺 通过特征大小和血液通道设计，与天然肺相似。我们的小型微通道人工肺达到了迄今为止所有人工肺中最高的气体交换效率。通过应用定制的、生物兼容的表面涂层，它们的寿命得到了提高。目前功绩评估提案的目标是：1)将我们的微通道人工肺的膜面积和额定流量增加100倍；2)通过释放一氧化氮进一步提高我们的微通道人工肺的生物相容性；以及3)在动物身上进行初步的气体交换和寿命研究。这些目标对于推动这项前景看好的技术朝着退伍军人肺康复的初始急性系统发展至关重要。

 DESCRIPTION (provided by applicant): The long-term goal of this technology development project is improve the rehabilitation of veterans suffering from lung diseases through the development of the first truly portable, biocompatible, artificial lung capable of short and long term respiratory support. Current artificil lungs have recently been used to rehabilitate lung disease patients; however, significant advances in gas exchange, biocompatibility, and portability are required to fully realize their potential. Microchannel artificial lungs promise to enable a new class of truly portable artificial lungs through feature sizes and blood channel designs that closely mimic those found in their natural counterpart. Our small-scale microchannel artificial lungs achieved the highest gas exchange efficiency of any artificial lung to date. Their lifetimes were improved through the application of custom, biocompatible surface coatings. The objectives of the current Merit Review proposal are to: 1) Increase the membrane area and rated flow of our microchannel artificial lung by a factor of 100X; 2) Further increase the biocompatibility of our microchannel artificial lung through nitric oxide release; and, 3) To perform initial gas exchange and lifetime studies in animals. These objectives are critical to advancing this promising technology towards initial acute systems for veteran pulmonary rehabilitation.