Cervicovaginal immune factors throughout the menstrual cycle: analysis of a cohort of Kenyan adolescents, systematic review, and meta-analysis
整个月经周期的宫颈阴道免疫因素:肯尼亚青少年队列分析、系统评价和荟萃分析
基本信息
- 批准号:10046430
- 负责人:
- 金额:$ 8.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-23 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescentAffectAgeAntigensBacterial VaginosisBiologicalBiological AssayBiological Response ModifiersBiologyChlamydiaComplementConflict (Psychology)DataDisease susceptibilityEnvironmentEquilibriumEthnic OriginFoundationsFutureGoalsGonorrheaHIVHealthHormonalHormonesHumanImmuneImmunityImmunologic FactorsImmunologicsImmunologyInner Cell MassInterventionIntervention StudiesIrrigationKnowledgeLaboratoriesLogisticsLuteal PhaseMeasuresMenstrual cycleMenstruationMeta-AnalysisMethodologyMethodsMucous MembraneOutcomeParticipantPhasePredispositionPrevention strategyProgesteroneProphylactic treatmentProteinsPublishingRaceReportingResearchResearch PersonnelResourcesSTI preventionSamplingScheduleSeminal fluidSerumSexually Transmitted DiseasesShapesSiteSpecimenSwabTechniquesTestingValidationVariantWomanbasecervicovaginalcohortgenital herpeshormonal contraceptioninclusion criteriainfection riskmeetingsmicrobiotamucosal vaccinationpathogenprimary outcomeproliferative phase Menstrual cyclereproductive tractsecondary outcomesperm cellsystematic review
项目摘要
PROJECT SUMMARY/ABSTRACT
Quantifying immune mediators within the cervicovaginal tract (CVT) enables researchers to assess
women's susceptibility to HIV and other sexually transmitted infections (STIs). Nearly twenty studies
have been published describing how immune factors in the CVT change during the menstrual cycle.
Despite this abundance of data, we lack a clear picture of the immune changes that occur, and it
remains completely unknown whether a specific phase in the menstrual cycle is associated with
increased disease susceptibility. This knowledge gap has important implications for research on
interventions to reduce STI risk in women. The primary goal of this project is to gain a comprehensive
understanding of how menstrual cycle phase affects immune factor concentrations in the CVT. Our first
aim is to perform a systematic review and meta-analysis of studies that have quantified immune
mediators from CVT specimens during the luteal and follicular phases of the menstrual cycle in women
who are not using hormonal contraception. Our preliminary data indicate that there are at least
seventeen published studies meeting inclusion criteria. In addition to assessing variation during the
menstrual cycle, we will also assess the impact of bacterial vaginosis, STIs (genital herpes, gonorrhea,
and chlamydia), race/ethnicity, and age. We will address technical questions of key importance to the
field, including the effect of CVT sample type, assay type, method of determining menstrual phase, and
data normalization technique. Our second aim is to extend and validate the meta-analysis using
samples from a cohort of 119 Kenyan adolescents ages 16-20 years (with a total of 200 samples). We
will use preliminary results from our first aim to inform which immune factors we select for the Kenyan
cohort, to both increase the number of immune factors that can be included in the meta-analysis and
validate the most important findings. We then plan to add results of this aim to the meta-analysis. As we
show in our preliminary data, by combining data from many studies, we can gain a comprehensive
understanding of mucosal immune changes that impact women's susceptibility to STIs. Understanding
these changes will provide an important foundation for future studies of health interventions (such as
STI prevention strategies, HIV prophylaxis, or hormonal contraception) and drive future research in the
basic immunology of the CVT.
项目总结/摘要
量化宫颈阴道道(CVT)内的免疫介质使研究人员能够评估
妇女易感染艾滋病毒和其他性传播感染。近20项研究
已经发表了描述CVT中的免疫因子在月经周期期间如何变化的文章。
尽管有如此丰富的数据,我们仍然缺乏对免疫变化的清晰描述,
仍然完全不清楚月经周期中的特定阶段是否与
增加疾病易感性。这一知识差距对以下方面的研究具有重要意义:
采取干预措施,降低妇女的性传播感染风险。该项目的主要目标是获得全面的
了解月经周期阶段如何影响CVT中的免疫因子浓度。我们的第一
目的是对量化免疫功能的研究进行系统回顾和荟萃分析,
女性月经周期黄体期和卵泡期CVT标本中的介质
不使用激素避孕的人我们的初步数据显示,
17项已发表的研究符合纳入标准。除了评估期间的变化外,
月经周期,我们还将评估细菌性阴道病,性传播感染(生殖器疱疹,淋病,
和衣原体)、种族/民族和年龄。我们将讨论对本组织至关重要的技术问题,
包括CVT样品类型、测定类型、确定月经期的方法的影响,以及
数据规范化技术我们的第二个目标是扩展和验证荟萃分析,
样本来自119名16-20岁的肯尼亚青少年(共200个样本)。我们
我将使用我们第一个目标的初步结果来告知我们为肯尼亚人选择哪些免疫因子。
队列,以增加可纳入荟萃分析的免疫因子数量,
验证最重要的发现。然后,我们计划将这一目标的结果添加到荟萃分析中。正如我们
我们的初步数据显示,通过结合多项研究的数据,我们可以获得一个全面的
了解影响妇女对性传播感染易感性的粘膜免疫变化。理解
这些变化将为未来的健康干预研究提供重要的基础(如
性传播感染预防战略、艾滋病毒预防或激素避孕),并推动未来在
CVT的基本免疫学
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Florian Hladik其他文献
Florian Hladik的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Florian Hladik', 18)}}的其他基金
Impact of the menstrual cycle on granulysin-mediated immunity in the human cervicovaginal tract
月经周期对人宫颈阴道颗粒溶素介导的免疫的影响
- 批准号:
10616798 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
The push and pull of inflammation on HIV susceptibility: impact of host variation in CD101 and AXL
炎症对 HIV 易感性的推拉:CD101 和 AXL 宿主变异的影响
- 批准号:
10546199 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
Impact of the menstrual cycle on granulysin-mediated immunity in the human cervicovaginal tract
月经周期对人宫颈阴道颗粒溶素介导的免疫的影响
- 批准号:
10450305 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
The push and pull of inflammation on HIV susceptibility: impact of host variation in CD101 and AXL
炎症对 HIV 易感性的推拉:CD101 和 AXL 宿主变异的影响
- 批准号:
10664009 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
The regulatory role of natural progesterone in barrier immunity
天然黄体酮在屏障免疫中的调节作用
- 批准号:
10604809 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
The regulatory role of natural progesterone in barrier immunity
天然黄体酮在屏障免疫中的调节作用
- 批准号:
10708998 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
Vaginal immune effects of testosterone in transmasculine individuals
睾酮对跨男性个体的阴道免疫影响
- 批准号:
10369028 - 财政年份:2021
- 资助金额:
$ 8.83万 - 项目类别:
Cervicovaginal immune factors throughout the menstrual cycle: analysis of a cohort of Kenyan adolescents, systematic review, and meta-analysis
整个月经周期的宫颈阴道免疫因素:肯尼亚青少年队列分析、系统评价和荟萃分析
- 批准号:
10222496 - 财政年份:2020
- 资助金额:
$ 8.83万 - 项目类别:
Extracellular vesicles in semen and genital HIV infection and immunity during heroin addiction and methadone or buprenorphine substitution therapy
海洛因成瘾和美沙酮或丁丙诺啡替代治疗期间精液中的细胞外囊泡和生殖器艾滋病毒感染和免疫
- 批准号:
9086328 - 财政年份:2015
- 资助金额:
$ 8.83万 - 项目类别:
Systems and carcinogenic impact assessment of topical microbicides on human mucosa
局部杀菌剂对人体粘膜的系统和致癌影响评估
- 批准号:
8922415 - 财政年份:2015
- 资助金额:
$ 8.83万 - 项目类别:
相似海外基金
Understanding How Adolescent Bullying Experiences Affect Traumatic Stress,Sexual Health and STI Risk among Men Who Have Sex with Men (MSM)
了解青少年欺凌经历如何影响男男性行为者 (MSM) 的创伤性压力、性健康和性传播感染风险
- 批准号:
10553263 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
Understanding How Adolescent Bullying Experiences Affect Traumatic Stress,Sexual Health and STI Risk among Men Who Have Sex with Men (MSM)
了解青少年欺凌经历如何影响男男性行为者 (MSM) 的创伤性压力、性健康和性传播感染风险
- 批准号:
10347813 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
Visuocortical Dynamics of Affect-Biased Attention in the Development of Adolescent Depression
青少年抑郁症发展过程中情感偏向注意力的视觉皮层动力学
- 批准号:
10380686 - 财政年份:2019
- 资助金额:
$ 8.83万 - 项目类别:
Visuocortical Dynamics of Affect-Biased Attention in the Development of Adolescent Depression
青少年抑郁症发展过程中情感偏向注意力的视觉皮层动力学
- 批准号:
9888437 - 财政年份:2019
- 资助金额:
$ 8.83万 - 项目类别:
Visuocortical Dynamics of Affect-Biased Attention in the Development of Adolescent Depression
青少年抑郁症发展过程中情感偏向注意力的视觉皮层动力学
- 批准号:
10597082 - 财政年份:2019
- 资助金额:
$ 8.83万 - 项目类别:
Targeting maladaptive responding to negative affect in adolescent cannabis users
针对青少年大麻使用者的负面影响的适应不良反应
- 批准号:
9371970 - 财政年份:2017
- 资助金额:
$ 8.83万 - 项目类别:
Childhood positive affect and anger as predictors of adolescent risky behavior
童年积极影响和愤怒是青少年危险行为的预测因素
- 批准号:
9139461 - 财政年份:2015
- 资助金额:
$ 8.83万 - 项目类别:
Do State Marijuana Policies Affect Adolescent Marijuana and Alcohol Use?
州大麻政策会影响青少年大麻和酒精的使用吗?
- 批准号:
8783159 - 财政年份:2014
- 资助金额:
$ 8.83万 - 项目类别:
Do State Marijuana Policies Affect Adolescent Marijuana and Alcohol Use?
州大麻政策会影响青少年大麻和酒精的使用吗?
- 批准号:
8853783 - 财政年份:2014
- 资助金额:
$ 8.83万 - 项目类别:
Assessment of Affect Instability in Adolescent Girls with BPD Features
具有 BPD 特征的青春期女孩的情绪不稳定评估
- 批准号:
8122499 - 财政年份:2011
- 资助金额:
$ 8.83万 - 项目类别: