Cervicovaginal immune factors throughout the menstrual cycle: analysis of a cohort of Kenyan adolescents, systematic review, and meta-analysis
整个月经周期的宫颈阴道免疫因素:肯尼亚青少年队列分析、系统评价和荟萃分析
基本信息
- 批准号:10046430
- 负责人:
- 金额:$ 8.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-23 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescentAffectAgeAntigensBacterial VaginosisBiologicalBiological AssayBiological Response ModifiersBiologyChlamydiaComplementConflict (Psychology)DataDisease susceptibilityEnvironmentEquilibriumEthnic OriginFoundationsFutureGoalsGonorrheaHIVHealthHormonalHormonesHumanImmuneImmunityImmunologic FactorsImmunologicsImmunologyInner Cell MassInterventionIntervention StudiesIrrigationKnowledgeLaboratoriesLogisticsLuteal PhaseMeasuresMenstrual cycleMenstruationMeta-AnalysisMethodologyMethodsMucous MembraneOutcomeParticipantPhasePredispositionPrevention strategyProgesteroneProphylactic treatmentProteinsPublishingRaceReportingResearchResearch PersonnelResourcesSTI preventionSamplingScheduleSeminal fluidSerumSexually Transmitted DiseasesShapesSiteSpecimenSwabTechniquesTestingValidationVariantWomanbasecervicovaginalcohortgenital herpeshormonal contraceptioninclusion criteriainfection riskmeetingsmicrobiotamucosal vaccinationpathogenprimary outcomeproliferative phase Menstrual cyclereproductive tractsecondary outcomesperm cellsystematic review
项目摘要
PROJECT SUMMARY/ABSTRACT
Quantifying immune mediators within the cervicovaginal tract (CVT) enables researchers to assess
women's susceptibility to HIV and other sexually transmitted infections (STIs). Nearly twenty studies
have been published describing how immune factors in the CVT change during the menstrual cycle.
Despite this abundance of data, we lack a clear picture of the immune changes that occur, and it
remains completely unknown whether a specific phase in the menstrual cycle is associated with
increased disease susceptibility. This knowledge gap has important implications for research on
interventions to reduce STI risk in women. The primary goal of this project is to gain a comprehensive
understanding of how menstrual cycle phase affects immune factor concentrations in the CVT. Our first
aim is to perform a systematic review and meta-analysis of studies that have quantified immune
mediators from CVT specimens during the luteal and follicular phases of the menstrual cycle in women
who are not using hormonal contraception. Our preliminary data indicate that there are at least
seventeen published studies meeting inclusion criteria. In addition to assessing variation during the
menstrual cycle, we will also assess the impact of bacterial vaginosis, STIs (genital herpes, gonorrhea,
and chlamydia), race/ethnicity, and age. We will address technical questions of key importance to the
field, including the effect of CVT sample type, assay type, method of determining menstrual phase, and
data normalization technique. Our second aim is to extend and validate the meta-analysis using
samples from a cohort of 119 Kenyan adolescents ages 16-20 years (with a total of 200 samples). We
will use preliminary results from our first aim to inform which immune factors we select for the Kenyan
cohort, to both increase the number of immune factors that can be included in the meta-analysis and
validate the most important findings. We then plan to add results of this aim to the meta-analysis. As we
show in our preliminary data, by combining data from many studies, we can gain a comprehensive
understanding of mucosal immune changes that impact women's susceptibility to STIs. Understanding
these changes will provide an important foundation for future studies of health interventions (such as
STI prevention strategies, HIV prophylaxis, or hormonal contraception) and drive future research in the
basic immunology of the CVT.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Florian Hladik其他文献
Florian Hladik的其他文献
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{{ truncateString('Florian Hladik', 18)}}的其他基金
The push and pull of inflammation on HIV susceptibility: impact of host variation in CD101 and AXL
炎症对 HIV 易感性的推拉:CD101 和 AXL 宿主变异的影响
- 批准号:
10546199 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
Impact of the menstrual cycle on granulysin-mediated immunity in the human cervicovaginal tract
月经周期对人宫颈阴道颗粒溶素介导的免疫的影响
- 批准号:
10616798 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
Impact of the menstrual cycle on granulysin-mediated immunity in the human cervicovaginal tract
月经周期对人宫颈阴道颗粒溶素介导的免疫的影响
- 批准号:
10450305 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
The push and pull of inflammation on HIV susceptibility: impact of host variation in CD101 and AXL
炎症对 HIV 易感性的推拉:CD101 和 AXL 宿主变异的影响
- 批准号:
10664009 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
The regulatory role of natural progesterone in barrier immunity
天然黄体酮在屏障免疫中的调节作用
- 批准号:
10604809 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
The regulatory role of natural progesterone in barrier immunity
天然黄体酮在屏障免疫中的调节作用
- 批准号:
10708998 - 财政年份:2022
- 资助金额:
$ 8.83万 - 项目类别:
Vaginal immune effects of testosterone in transmasculine individuals
睾酮对跨男性个体的阴道免疫影响
- 批准号:
10369028 - 财政年份:2021
- 资助金额:
$ 8.83万 - 项目类别:
Cervicovaginal immune factors throughout the menstrual cycle: analysis of a cohort of Kenyan adolescents, systematic review, and meta-analysis
整个月经周期的宫颈阴道免疫因素:肯尼亚青少年队列分析、系统评价和荟萃分析
- 批准号:
10222496 - 财政年份:2020
- 资助金额:
$ 8.83万 - 项目类别:
Extracellular vesicles in semen and genital HIV infection and immunity during heroin addiction and methadone or buprenorphine substitution therapy
海洛因成瘾和美沙酮或丁丙诺啡替代治疗期间精液中的细胞外囊泡和生殖器艾滋病毒感染和免疫
- 批准号:
9086328 - 财政年份:2015
- 资助金额:
$ 8.83万 - 项目类别:
Systems and carcinogenic impact assessment of topical microbicides on human mucosa
局部杀菌剂对人体粘膜的系统和致癌影响评估
- 批准号:
8922415 - 财政年份:2015
- 资助金额:
$ 8.83万 - 项目类别:
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