Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Scientific and Data Coordinating Center

下尿路症状预防 (PLUS) 研究联盟科学和数据协调中心

• 批准号: 10053401
• 负责人: BERNARD L HARLOW
• 金额: $ 200万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10053401
• 关键词: Address; Adolescence; Adopted; Advocate; Affect; Age; Athletic; Attitude; Award; Behavior; Belief; Biology; Biometry; Biostatistical Methods; Bladder; Clinical; Collaborations; Communities; Community Developments; Community Networks; Data; Data Analyses; Data Collection; Data Coordinating Center; Development; Device or Instrument Development; Disease; Enuresis; Environment; Ethics; Evaluation; Feasibility Studies; Fostering; Future; Goals; Grant; Health; Health Status; Housing; Intervention; Knowledge; Lead; Leadership; Life Cycle Stages; Logistics; Longevity; Longitudinal cohort study; Measurement; Measures; Modeling; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Observational Study; Pain; Pathology; Perception; Persons; Phase; Pilot Projects; Positioning Attribute; Prevention; Prevention strategy; Preventive Intervention; Primary Prevention; Process; Psychometrics; Quality of life; Research; Research Personnel; Review Literature; Risk Factors; Role; Science; Secondary Prevention; Site; Social Interaction; Societies; Source; Stress Urinary Incontinence; Symptoms; Techniques; Testing; Time; Treatment Efficacy; Update; Urethra; Urinary Incontinence; Urinary tract infection; Urination; Woman; Work; aged; base; bedwetting; biopsychosocial; clinical care; data management; design; dissemination research; epidemiology study; evidence base; experience; girls; innovation; instrument; lower urinary tract symptoms; meetings; member; men; modifiable risk; novel; population based; prevent; programs; prospective; protective factors; research study; urologic; web site

Project Summary Lower urinary tract symptoms (LUTS) encompass a variety of bothersome storage and emptying symptoms, including urgency and stress urinary incontinence, frequent and/or urgent urination, nocturnal enuresis (i.e., bed-wetting), difficulty urinating, dribbling after urination, and bladder or urethral pain before, during, or after urination. More than 200 million people worldwide and over 15% of women aged 40 years or older suffer from urinary incontinence. In fact, women are 2-3 times more likely to experience urinary incontinence and 4 times more likely to experience a urinary tract infection in comparison to men. For decades LUTS research has focused on underlying pathology, disease mechanisms, and treatment efficacy. The NIDDK took a bold step by introducing the concept of prevention as an important priority for women's urologic research. Through its transdisciplinary team science approach, the Prevention of Lower Urinary tract Symptoms Research Consortium (PLUS-RC) is creating new conceptual models and paradigms, developing innovative measures, establishing evidence, and leading and seeding research on bladder health and LUTS prevention. As the Scientific and Data Coordinating Center (SDCC) for this unique consortium since its inception, we are excited to further develop the evidence base to empower women and their communities to advocate for an environment that supports healthy bladders. During this next grant period, we plan to (1) provide leadership, management, and biostatistical support in the design and implementation of a nationally and regionally representative prospective longitudinal cohort study to assess the distribution of bladder health and evaluate potential risk and protective factors that influence bladder health status; (2) provide leadership, management, and biostatistical support in the analysis of existing studies (quantitative and qualitative) that will lead to the collaborative development of conceptual models that guide analyses within the observational study above, and new studies that support future primary or secondary prevention initiatives; (3) provide leadership in the principles and process devoted to item development, instrument development, and psychometric evaluation and scoring; (4) facilitate a network of community stakeholders to assist and collaborate in the process of data collection development, execution, and dissemination; (5) foster transdisciplinary team science across all consortium activities and centers; and (6) provide administrative leadership and logistical support and coordination of meetings of the Steering Committee, all subcommittees, the Executive Committee, the External Expert Panel, and the pilot and feasibility studies program, for the efficient and ethical execution of consortium objectives.

项目摘要 下尿路症状（LUTS）包括各种令人烦恼的储存和排空症状， 包括尿急和压力性尿失禁、尿频和/或尿急，夜间遗尿症（即， 尿床），排尿困难，排尿后滴尿，以及之前、期间或之后的膀胱或尿道疼痛 小便全世界有2亿多人和超过15%的40岁或以上的妇女患有 尿失禁事实上，女性患尿失禁的可能性是男性的2-3倍， 与男性相比，更容易发生尿路感染。几十年来，LUTS研究 重点是潜在的病理学，疾病机制和治疗效果。NIDDK迈出了大胆的一步， 将预防的概念作为妇女泌尿学研究的一个重要优先事项。 通过其跨学科团队的科学方法，下尿路症状的预防 研究联盟（PLUS-RC）正在创建新的概念模型和范式，开发创新的 措施，建立证据，并领导和播种膀胱健康和LUTS预防的研究。 自成立以来，作为这个独特联盟的科学和数据协调中心（SDCC），我们 很高兴进一步开发证据库，以增强妇女及其社区倡导 支持健康膀胱的环境。 在下一个资助期内，我们计划（1）提供领导，管理和生物统计支持， 设计和实施一项具有国家和地区代表性的前瞻性纵向队列研究， 评估膀胱健康的分布，并评估潜在的风险和保护因素， 膀胱健康状况;（2）提供领导，管理和生物统计支持，分析现有的 研究（定量和定性）将导致概念模型的协作开发， 指导上述观察性研究中的分析，以及支持未来主要或次要研究的新研究 预防举措;（3）在项目开发的原则和过程中发挥领导作用， 工具开发，心理测量评估和评分;（4）促进社区网络 利益相关者在数据收集开发、执行和 传播;（5）在所有联盟活动和中心中促进跨学科团队科学;以及（6） 提供行政领导和后勤支助，并协调指导委员会的会议 委员会、所有小组委员会、执行委员会、外部专家小组以及试点和 可行性研究计划，以有效和道德的执行财团的目标。