Prevention of Lower Urinary Tract Symptoms in Women: Bladder Health Scientific and Data Coordinating Center (PLUS-SDCC) (U01)

 描述（由申请人提供）：女性的下尿路症状（LUTS）是疾病、疼痛和尴尬的来源，可能影响女性从青春期到老年的工作、社会交往以及体育和娱乐活动。几乎50%的女性会在一生中的某个时候经历LUTS。症状本身就很有害，但如果不加以治疗，它们会导致更严重的问题，如失禁，感染，盆腔炎和心理困扰。NIDDK妇女下尿路症状预防研究联盟（PLUS-RC）计划旨在通过开展必要的研究，广泛识别和评估LUTS风险和保护因素的相对重要性，为妇女下尿路症状和疾病的未来预防干预研究建立科学基础。了解这些风险因素可以制定干预策略，这些策略可能在未来的临床试验中得到验证。PLUS-RC科学和数据协调中心（SDCC）的具体目标是：（1）对文献进行审查并对既往出版物进行荟萃分析;（2）与其他PLUS-RC研究者一起，计划、设计和优先考虑新的LUTS流行病学和临床研究，并实施辅助研究计划;（3）提供数据协调和监测能力，以支持PLUS-RC研究;（4）提供全面和创新的数据分析，以支持成果的展示和出版，并构建高质量的数据集，供其他研究人员使用;（5）为指导和规划委员会、所有小组委员会以及外部专家小组的会议和电话会议提供后勤支持，以有效和道德地执行联合体目标。我们汇集了一支独特的强大团队，在生物统计学，流行病学和大型多中心研究的开展方面有着悠久的历史，在荟萃分析，观察数据分析，流行病学方面有着广泛的专业知识，特别是与女性健康，行为矫正和预防科学方面的技能，以及在诊断和治疗女性LUTS方面的临床护理经验。

 DESCRIPTION (provided by applicant): Lower urinary tract symptoms (LUTS) in women are a source of illness, pain, and embarrassment, which can affect work, social interactions, and athletic and recreational activities in women from adolescence to old age. Almost 50% of women will experience LUTS at some point in their lifetime. Symptoms are harmful enough in themselves, but untreated, they can lead to more serious problems such as incontinence, infections, pelvic inflammation and psychological distress. The NIDDK program on Prevention of Lower Urinary tract Symptoms in women Research Consortium (PLUS-RC) is intended to broadly identify and evaluate the relative importance of the risk and protective factors for LUTS by conducting the necessary research studies to establish the scientific basis for future prevention intervention studies for lower urinary tract symptoms and conditions in women. Knowledge of such risk factors can lead to interventional strategies, which may be testable in future clinical trials. Specific aims of the PLUS-RC Scientific and Data Coordinating Center (SDCC) are to (1) conduct reviews of literature and meta-analyses of previous publications; (2) with the other PLUS-RC investigators, plan, design, and prioritize new epidemiologic and clinical studies of LUTS and implement an ancillary studies program; (3) provide data coordination and monitoring capabilities in support of PLUS-RC research studies; (4) provide comprehensive and innovative data analyses in support of presentation and publication of results, and construct high-quality datasets, which will be available to other researchers; and (5) provide logistical support for meetings and conference calls of the Steering and Planning Committee, all subcommittees, and an External Expert Panel for the efficient and ethical execution of consortium objectives. We bring together a uniquely strong team with a long history of accomplishment in biostatistics, epidemiology, and the conduct of large multi-center studies, extensive expertise in meta-analysis, observational data analysis, epidemiology specifically related to women's health, skills in behavioral modification and prevention science, and clinical care experience in the diagnosis and treatment of LUTS in women.