Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Scientific and Data Coordinating Center

项目摘要 下尿路症状(LUT)包括各种烦人的储存和排空症状， 包括紧迫性和压力性尿失禁、尿频和/或尿急、夜间遗尿(即， 尿床)，排尿困难，排尿后流口水，以及前、中或后的膀胱或尿路疼痛 小便。全球超过2亿人和超过15%的40岁或40岁以上的女性患有 尿失禁。事实上，女性尿失禁的可能性是女性的2-3倍和4倍 与男性相比，更有可能经历尿路感染。几十年来，LUTS研究一直 侧重于基础病理、发病机制和治疗效果。NIDDK迈出了大胆的一步 将预防概念作为女性泌尿外科研究的重要优先事项。 通过其跨学科的团队科学方法，预防下尿路症状 研究联盟(PLUS-RC)正在创建新的概念模型和范例，开发创新的 措施，建立证据，领导和播撒关于膀胱健康和下尿路感染预防的研究。 作为这个独特联盟自成立以来的科学和数据协调中心(SDCC)，我们 很高兴进一步发展证据基础，使妇女和她们的社区能够倡导 支持健康膀胱的环境。 在下一个资助期，我们计划(1)提供领导、管理和生物统计学方面的支持 设计和实施一项具有全国和区域代表性的前瞻性纵向队列研究 评估膀胱健康的分布，评估潜在的风险和影响的保护因素 膀胱健康状况；(2)提供领导、管理和生物统计学支持，分析现有 将导致合作开发概念模型的研究(定量和定性) 指导上述观察性研究中的分析，以及支持未来主要或次要研究的新研究 预防举措；(3)领导致力于项目开发的原则和进程； 工具开发、心理测量评估和评分；(4)促进社区网络 利益相关者在数据收集开发、执行和管理过程中协助和协作 传播；(5)促进所有联盟活动和中心的跨学科团队科学；和(6) 提供行政领导和后勤支持，并协调指导会议 委员会、所有小组委员会、执行委员会、外部专家小组以及试点和 可行性研究计划，以有效和合乎道德的方式执行财团目标。

Project Summary Lower urinary tract symptoms (LUTS) encompass a variety of bothersome storage and emptying symptoms, including urgency and stress urinary incontinence, frequent and/or urgent urination, nocturnal enuresis (i.e., bed-wetting), difficulty urinating, dribbling after urination, and bladder or urethral pain before, during, or after urination. More than 200 million people worldwide and over 15% of women aged 40 years or older suffer from urinary incontinence. In fact, women are 2-3 times more likely to experience urinary incontinence and 4 times more likely to experience a urinary tract infection in comparison to men. For decades LUTS research has focused on underlying pathology, disease mechanisms, and treatment efficacy. The NIDDK took a bold step by introducing the concept of prevention as an important priority for women's urologic research. Through its transdisciplinary team science approach, the Prevention of Lower Urinary tract Symptoms Research Consortium (PLUS-RC) is creating new conceptual models and paradigms, developing innovative measures, establishing evidence, and leading and seeding research on bladder health and LUTS prevention. As the Scientific and Data Coordinating Center (SDCC) for this unique consortium since its inception, we are excited to further develop the evidence base to empower women and their communities to advocate for an environment that supports healthy bladders. During this next grant period, we plan to (1) provide leadership, management, and biostatistical support in the design and implementation of a nationally and regionally representative prospective longitudinal cohort study to assess the distribution of bladder health and evaluate potential risk and protective factors that influence bladder health status; (2) provide leadership, management, and biostatistical support in the analysis of existing studies (quantitative and qualitative) that will lead to the collaborative development of conceptual models that guide analyses within the observational study above, and new studies that support future primary or secondary prevention initiatives; (3) provide leadership in the principles and process devoted to item development, instrument development, and psychometric evaluation and scoring; (4) facilitate a network of community stakeholders to assist and collaborate in the process of data collection development, execution, and dissemination; (5) foster transdisciplinary team science across all consortium activities and centers; and (6) provide administrative leadership and logistical support and coordination of meetings of the Steering Committee, all subcommittees, the Executive Committee, the External Expert Panel, and the pilot and feasibility studies program, for the efficient and ethical execution of consortium objectives.