Animal Modeling Core

动物建模核心

• 批准号: 10060459
• 负责人: Richard A. Flavell
• 金额: $ 27.38万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10060459
• 关键词: Animal Model; Basic Science; Benign; Biological Assay; Blood Circulation; Blood Platelets; Cells; Communities; Disease; Educational process of instructing; Erythrocytes; Goals; Hematological Disease; Hematology; Hematopoiesis; Hematopoietic stem cells; Human; Immune system; Immunobiology; Immunodeficient Mouse; Mission; Modeling; Mus; Myeloid Cells; Population; Research; Research Personnel; Resources; Scientist; Stem cell transplant; Study models; Technical Expertise; Technology; Tissues; Training; Xenograft procedure; hematopoietic cell transplantation; humanized mouse; in vivo; innovation; mid-career faculty; mouse model; novel; professor; translational study

PROJECT SUMMARY/ The mission of the Animal Modeling Core (AMC) is to provide research groups within the YCCEH and the larger scientific community access to the latest technologies for hematologic studies in animal models. In vivo studies allow researchers to ask questions about the function of molecules, cell populations, and tissues within the relevant spatial and temporal contexts. The YCCEH will continue to provide scientists training and facilitate research in mouse models of hematologic diseases. Importantly, the AMC will continue to develop and propagate the most innovative humanized mouse models for the study of human hematopoiesis and diseases thereof with the goal to overcome major shortcomings of current models. The AMC consists of two cores, the Humanized Mouse Core (HMC) and the Murine Stem Cell Transplantation Core (mSCTC). The Animal Modeling Core will be directed by Dr Richard Flavell, Sterling Professor of Immunobiology and co-directed by Dr. Stephanie Halene, Associate Professor and Acting Section Chief of Hematology. The HMC will offer expertise, technical assistance, and mice for human-into-mouse xenotransplantation studies. The mSCTC will offer training and technical assistance in the study of hematopoiesis and benign hematologic questions in mice. The Humanized Mouse Core will facilitate human-into-mouse xenotransplantation studies into immunodeficient mice. As a unique feature the Yale HMC will offer hematology researchers access to novel humanized immunodeficient mice optimized to support human hematopoietic stem cells, trilineage hematopoiesis, mature myeloid cells, red cells and platelets in circulation, and a functional human immune system. The Murine Stem Cell Transplantation Core will provide technical expertise in the study of hematologic questions in mice. The mSCTC will offer training and expertise for the study of hematopoiesis and hematologic diseases in mice using hematopoietic cell transplantation and functional assays. The Animal Modeling Core will be an integral part of the YCCEH. It will provide Hematology researchers with access to state-of-the-art technologies for in vivo studies of hematopoiesis and hematologic diseases. It will provide teaching, expertise, and resources in an economical way. Its cores will support basic science as well as translational studies, key to understanding and cure of hematologic diseases.

项目概要/ 动物模型核心（AMC）的使命是为YCCEH和更大的研究小组提供 科学界获得动物模型血液学研究的最新技术。体内研究 允许研究人员询问有关分子，细胞群和组织内的功能的问题。 相关的时空背景。YCCEH将继续为科学家提供培训， 血液病小鼠模型的研究。重要的是，AMC将继续发展和传播 用于研究人类造血及其疾病的最具创新性的人源化小鼠模型， 目标是克服现有模式的主要缺点。AMC由两个核心组成，人性化 小鼠核心（HMC）和小鼠干细胞移植核心（mSCTC）。动物模型核心将 由Sterling免疫生物学教授Richard Flavell博士指导，Stephanie Halene博士共同指导， 副教授，血液科代理科长。HMC将提供专业知识，技术援助， 和小鼠用于人到小鼠异种移植研究。mSCTC将提供培训和技术 协助研究小鼠的造血和良性血液学问题。人源化老鼠 Core将促进免疫缺陷小鼠的人鼠异种移植研究。作为一个独特的功能 耶鲁大学HMC将为血液学研究人员提供新的人源化免疫缺陷小鼠， 支持人造血干细胞、三系造血、成熟髓系细胞、红细胞和血小板 以及正常的人体免疫系统。小鼠干细胞移植核心将提供 小鼠血液学问题研究的技术专长。mSCTC将提供培训和专业知识 用于使用造血细胞移植在小鼠中研究造血和血液病， 功能测定动物模型核心将是YCCEH的一个组成部分。它将提供血液学 研究人员可以使用最先进的技术进行造血和血液学的体内研究 疾病它将以经济的方式提供教学，专业知识和资源。它的核心将支持基本的 科学以及转化研究，理解和治疗血液病的关键。