SCH: Acoustic Sensing-Based Wearable system for Monitoring Social Dysfunction in Schizophrenia

SCH：基于声学传感的可穿戴系统，用于监测精神分裂症的社交功能障碍

• 批准号: 10022334
• 负责人: JIE XIONG
• 金额: $ 29.01万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-23 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10022334
• 关键词: Acoustics; Affect; Algorithms; American; Area; Behavior; Behavioral; Categories; Clinical; Clinical Sciences; Cues; Data; Data Science; Data Set; Development; Devices; Education; Educational workshop; Engineering; Environment; Family member; Friends; Furniture; General Hospitals; Goals; Grain; Health; Human; Individual; Instruction; Interdisciplinary Study; K-12 student; Laboratories; Lead; Life; Limes; Massachusetts; Measurement; Measures; Methods; Mission; Monitor; Motivation; National Institute of Mental Health; Neck; Outcome; Participant; Patients; Pattern; Performance; Personal Space; Personality Disorders; Persons; Plant Roots; Post-Traumatic Stress Disorders; Process; Psychiatry; Quality of life; Research; Research Project Grants; Resolution; Robotics; SMART health; Schizophrenia; Series; Severities; Signal Transduction; Social Behavior; Social Functioning; Social Interaction; Social Phobia; Societies; Symptoms; Techniques; Therapeutic Intervention; Time; Training; Ultrasonography; United States; Universities; Walking; Wearable Computer; Wireless Technology; autism spectrum disorder; base; computer human interaction; design; disability; improved; individual patient; medical schools; neuropsychiatric disorder; novel; personalized management; severe mental illness; signal processing; social; social deficits; undergraduate student; wearable sensor technology

Schizophrenia is a severe mental disorder that affects how a person thinks, feels, and behaves. It is associated with subtle abnormalities in day-to-day social behaviors and one of the leading causes of disability in the United States. Unfortunately, little is known about the abnormalities in real-world social functioning in individuals with schizophrenia, how their abnormalities correlate with clinical symptoms and progress over time as a consequence of therapeutic interventions. The real-world assessment of personal space - the physical distance that one maintains from others during social interactions - can be used to develop and efficiently evaluate potential treatments for schizophrenia and help improve patients' day-to- day functioning. The goal of this study is to objectively quantify the amount of real-world social interactions and the physical distance maintained from others in individuals with schizophrenia. Specific research aims include: 1) Design and implement a neck-worn device that employs acoustic signals to detect human targets that the patient interacts with. 2) Design a method to simultaneously measure the distance between the patient and multiple targets at an accuracy level of 2 cm with ultrasound. 3) Explore the unique markers of social functioning in healthy individuals and patients with schizophrenia by integrating the personal space information and other multi-dimensional contextual and behavioral information, and 4) Develop an algorithm that extracts relevant features from the obtained data that can be used to assess the level of social motivation and the severity of symptoms in schizophrenia patients. We believe that progress towards moving schizophrenia treatment to a scientific process rooted in objective measurement and performance in the real-world would contribute to a major paradigm shift in the field. More specifically, the outcomes of the proposed research - if successful - will transform the understanding and treatment of schizophrenia, opening a new door leading to previously unexplored datasets and potentially new development of personalized disease management, which well-aligns with the mission of the National Institute of Mental Health. RELEVANCE (See Instructions): The real-world assessment of personal space can be used to develop and evaluate potential treatments for schizophrenia and help improve patients' day-to-day functioning. The goal of this study is to objectively quantify the amount of real-world social interactions and the physical distance maintained from others in individuals with schizophrenia. The proposed study will open a new door leading to previously unexplored datasets and new development of personalized disease management in schizophrenia.

精神分裂症是一种严重的精神障碍，会影响一个人的想法，感觉和行为。这是 与日常社会行为的微妙异常相关，也是主要原因之一 美国的残疾。不幸的是，对现实世界中社会的异常知之甚少 精神分裂症患者的功能，其异常与临床症状和 由于治疗干预措施，随着时间的推移会随着时间的流逝而进展。个人评估 空间 - 一个人在社交互动期间与他人保持的身体距离 - 可以用来 开发并有效评估精神分裂症的潜在治疗方法，并有助于改善患者的日常治疗 日常运作。这项研究的目的是客观地量化现实世界互动的数量 精神分裂症患者与其他人保持身体距离。具体的研究目的 包括：1）设计和实施使用声学信号来检测人类的颈部损坏的设备 患者与患者相互作用的目标。 2）设计一种同时测量距离的方法 超声检查的患者和多个目标的精度为2 cm。 3）探索独特的标记 通过整合健康的个人和精神分裂症患者的社会功能 空间信息以及其他多维上下文和行为信息，以及4） 从获得的数据中提取相关特征的算法，可用于评估 精神分裂症患者的社会动机和症状的严重程度。我们相信，朝着 将精神分裂症治疗转移到植根于客观测量和性能的科学过程 在现实世界中，将导致该领域的重大范式转变。更具体地说，结果 拟议的研究（如果成功）将改变对精神分裂症的理解和治疗， 打开一个新的门，导致以前未开发的数据集，并可能是新的开发 个性化疾病管理，与国家心理研究所的使命很好地保持一致 健康。 相关性（请参阅说明）： 个人空间的现实评估可用于开发和评估潜在的治疗方法 精神分裂症并帮助改善患者的日常功能。这项研究的目的是客观地量化 现实世界中的社交互动和与他人与他人保持的身体距离的数量 精神分裂症。拟议的研究将打开一个新的门，导致以前未开发的数据集和新的新门 发展精神分裂症的个性化疾病管理。