Administrative Core

管理核心：摘要 哥伦比亚大学乔治M.奥布莱恩泌尿科合作研究中心正在研究 泌尿道发育异常和宿主防御机制改变在膀胱癌发病机制中的作用 尿路感染（UTI）及其并发症。这项工作建立在前五年供资的基础上， 汇集了一个由临床、转化和基础科学家组成的多学科协作团队， 在更好地了解泌尿系统功能障碍和疾病方面取得了重大进展。在这次更新中， 申请，哥伦比亚奥布莱恩中心包括三个研究项目，一个新的微生物基因组学 生物医学核心（MGBC）和行政（管理）核心。管理核心将是一个核心组成部分， 通过为所有奥布莱恩活动提供科学的领导和组织结构， 负责所有财务、行政、通讯和数据传播职能。重要思想为指导 从内部和外部咨询委员会，执行委员会将提供多学科 科学的领导，以实施管理计划，并确保项目和MGBC是 实现他们的目标。执行委员会还将维护所有各方之间存在的强大协同作用， 奥布莱恩合作研究中心，继续与多个NIDDK计划互动，并确保有效的 在更广泛的泌尿外科社区进行交流和数据共享。此外， 行政核心将支持和管理奥布莱恩教育丰富和机会池 程序.教育丰富计划包括哥伦比亚奥布莱恩暑期学生研究 计划，一个密集的10周的实验室实习，医学和研究生，本科生和 高中生接受泌尿科研究和职业道路培训。教育丰富化 该计划与哥伦比亚的多元化导向的推广和医生科学家培训计划相结合， 促进良性泌尿生殖系统疾病领域的研究事业。机会池计划将 继续通过严格的内部和NIDDK结构化流程选择特殊项目， 重点是识别和合作有前途的年轻或建立的研究人员，他们的研究是 适用于泌尿外科领域之外的领域。通过这些活动，行政核心将促进研究 哥伦比亚奥布莱恩中心和更大的奥布莱恩合作网络的使命。

ADMINISTRATIVE CORE: ABSTRACT The overall goal of the Columbia University George M. O’Brien Urology Cooperative Research Center is to study the role of abnormal urinary tract development and altered host defense mechanisms in the pathogenesis of urinary tract infections (UTIs) and their complications. This work builds on the previous five years of funding and has brought together a collaborative, multidisciplinary team of clinical, translational, and basic scientists that have taken significant strides in better understanding urologic dysfunction and disease. In this renewal application, the Columbia O’Brien Center consists of three Research Projects, a new Microbial Genomics Biomedical Core (MGBC), and an Administrative (Admin) Core. The Admin Core will be a central component of the Center by providing scientific leadership and organizational structure for all O’Brien activities, and will be responsible for all financial, administrative, communication, and data dissemination functions. With guidance from the Internal and External Advisory Committees, the Executive Committee will provide multidisciplinary scientific leadership to implement the management plan and ensure that the projects and the MGBC are achieving their aims. The Executive Committee will also safeguard the strong synergies that exist between all O’Brien Cooperative Research Centers, continue to interact with multiple NIDDK programs, and ensure effective communication and data sharing throughout the broader urology community. Additionally, a key function of the Admin Core will be to support and administer the O’Brien Educational Enrichment and Opportunity Pool Programs. The Educational Enrichment Program includes the Columbia O’Brien Summer Student Research Program, an intensive 10-week laboratory internship where medical and graduate students, undergraduates and high-school students are exposed to urologic research and career path training. The Educational Enrichment Program is coupled to Columbia’s diversity-oriented outreach and physician-scientist training programs to promote research careers in the field of benign genitourinary diseases. The Opportunity Pool Program will continue its selection of exceptional projects through a rigorous internal and NIDDK-structured process that focuses on identifying and collaborating with promising young or established investigators whose research is applicable to but outside the field of Urology. Through these activities, the Admin Core will promote the research mission of the Columbia O’Brien Center and the larger O’Brien Cooperative Network.