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Using single-cell RNA-seq to interrogate host immunity to pathogens

Using single-cell RNA-seq to interrogate host immunity to pathogens
使用单细胞 RNA-seq 探究宿主对病原体的免疫力
批准号：
9753899
负责人：
John T Chang
金额：
$57.0万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
项目状态：
已结题
起止时间：
2016-09-23 至 2021-08-31
来源：
https://reporter.nih.gov/project-details/9753899
关键词：
AcuteBacteriaBacterial InfectionsBiomedical ResearchCD8-Positive T-LymphocytesCause of DeathCellsCommunicable DiseasesDevelopmentExhibitsGene Expression ProfilingGeneticGoalsHeterogeneityImmune systemImmunityImmunologic MemoryIndividualInfectionKnock-outListeria monocytogenesLymphocyteMemoryMolecularPopulationRNA ComputationsRegulator GenesResearchSystemic infectionT memory cellT-LymphocyteT-Lymphocyte SubsetsTranscriptional RegulationVaccine DesignVaccinesVirusadaptive immune responseadaptive immunitybasedesignimprovedin vivoinsightknock-downmicrobialmortalityneutralizing antibodynovelnovel vaccinesoral infectionpathogenresponsesingle cell mRNA sequencingsingle-cell RNA sequencingsmall hairpin RNAterminally differentiated effector memory (TEM) T cellstranscriptometranscriptomicsvaccination strategy

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中文摘要
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英文摘要
Project Summary Mortality from infectious diseases remains a leading cause of death worldwide, making the development of new vaccines an important priority of biomedical research. Immunologic memory is a cardinal feature of adaptive immunity and an important goal of vaccination strategies. Traditional vaccination strategies are very effective at generating neutralizing antibodies against bacteria and viruses. However, a vaccine capable of generating robust T lymphocyte memory is still beyond our research, due, in part, to an incomplete understanding of the molecular basis of lymphocyte fate specification. In this proposal, we will develop single-cell approaches to study specification of lymphocyte fates in response to microbial infection.
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T cell subsets in inflammatory bowel disease
  • 批准号：
    10569030
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    2022
  • 负责人：
    John T Chang
  • 依托单位：
    VA SAN DIEGO HEALTHCARE SYSTEM
T cell subsets in inflammatory bowel disease
  • 批准号：
    10364307
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  • 资助金额：
    $0.0万
  • 财政年份：
    2022
  • 负责人：
    John T Chang
  • 依托单位：
    VA SAN DIEGO HEALTHCARE SYSTEM
Transcriptional regulation of T cell immunity
  • 批准号：
    10341041
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    2021
  • 负责人：
    John T Chang
  • 依托单位：
    VA SAN DIEGO HEALTHCARE SYSTEM
Transcriptional regulation of T cell immunity
  • 批准号：
    10008141
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  • 资助金额：
    $0.0万
  • 财政年份：
    2021
  • 负责人：
    John T Chang
  • 依托单位：
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国内基金
海外基金
Segmented Filamentous Bacteria激活宿主免疫系统抑制其拮抗菌 Enterobacteriaceae维持菌群平衡及其机制研究
  • 批准号：
    81971557
  • 项目类别：
    面上项目
  • 资助金额：
    65.0万元
  • 批准年份：
    2019
  • 负责人：
    毛开睿
  • 依托单位：
    厦门大学
电缆细菌(Cable bacteria)对水体沉积物有机污染的响应与调控机制