Reducing Craving for Cancer-promoting Foods Via Cognitive Self-regulation

通过认知自我调节减少对致癌食物的渴望

• 批准号: 8636171
• 负责人: Elliot Todd Berkman
• 金额: $ 18.92万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-24 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8636171
• 关键词: Advanced Malignant Neoplasm; Affective; Anterior; Automobile Driving; Aversive Stimulus; Behavior; Behavioral; Brain; Cell Nucleus; Clinical; Cognitive; Colon; Complement; Conscious; Consumption; Cues; Data; Diet; Eating; Eating Behavior; Effectiveness; Emotional; Energy Intake; Food; Glycemic Index; Goals; Hunger; Image; Individual; Informal Social Control; Intake; Laboratories; Lateral; Link; Liver; Malignant Neoplasms; Malignant neoplasm of esophagus; Measures; Meat; Medial; Mediating; Motivation; Neurosciences; Obesity; Outcome; Overweight; Participant; Patient Self-Report; Pharmaceutical Preparations; Prefrontal Cortex; Process; Psychological Theory; Psychology; Questionnaires; Randomized; Reaction; Recurrence; Regulation; Research; Research Personnel; Risk Factors; Route; Science; Services; Social Psychology; Source; Stimulus; System; Testing; Theoretical model; Thinking; Visit; Weight; Work; World Health; approach behavior; base; behavior measurement; cancer prevention; cancer risk; cigarette smoking; comparative efficacy; cost; cost effective; craving; cue reactivity; design; emotion regulation; evidence base; food craving; improved; indexing; insight; neuroimaging; public health relevance; relating to nervous system; response; restraint; social neuroscience; social science research; theories; tool

DESCRIPTION (provided by applicant): Eating energy-dense foods when one is not hungry is a contributor to overweight and obesity, which are risk factors for a range of cancers. Excessive eating of a subset of these foods, such as red meat or foods with a high glycemic index, is an additional risk factor for cancer, separate from overweight and obesity. We refer to foods that are linked to cancer through either or both routes as cancer-promoting foods. The goal of this project is to reduce cancer risk by improving cognitive self-regulation of cravings for cancer-promoting foods. We focus on craving of cancer-promoting foods as one proximal determinant of their consumption. Craving consists of a subjective sense of wanting to eat a food, a motivation to seek out the food, and recurrent or intrusive thoughts related to the food. Considerable research shows that craving is a strong predictor of eating, even in the absence of hunger. Thus, enhancing a simple, low-cost and easily disseminated tool to reduce craving for cancer-promoting foods would advance cancer prevention and related research. Studies from affective science and social neuroscience have identified cognitive self-regulation strategies that are effective in reducing craving and their associated neural systems. This work has focused mostly on craving for other appetitive stimuli (e.g., drug cues), and has only begun to study regulation of food craving. Recent results from our laboratory validated four strategies that are effective in reducing cravings for energy-dense foods. This work relies upon self-reports of craving, which provide an empirical starting point but do not demonstrate the validity of the strategies on their own. Thus, the goals of the proposed project are to provide additional support for the effectiveness of cognitive self-regulation of food cravings using other measures beyond self-report, and to validate a theoretically grounded means to further increase the efficacy of those strategies-strategy choice. These goals will be accomplished in the context of a single study with two sessions. First, participants will be randomly assigned to choose their regulation strategy or to have one selected for them. In Session 1, their self-reported cravings and neural responses will be recorded while they alternately view images of energy- dense foods and regulate their responses to those foods. These data will be used to examine the effects of food regulation on neural activation and self-reports of craving, and to compare the effect of strategy choice on those measures. In Session 2, participants will visit our behavioral laboratory three days following Session 1 for a session in which their actual intake of energy-dense food will be measured in a naturalistic and unobtrusive manner. The difference in energy-dense food intake between the two groups will provide a behavioral measure of the efficacy of strategy choice on eating. Also, brain activity during food cue reactivity and regulation from Session 1 will be used to predict intake during Session 2. Psychological theory and previous neuroscience data suggest that neural activity, particularly in the medial prefrontal cortex, might explain variance in energy-dense food intake above and beyond self-report, and might mediate the effect of strategy choice on intake.

描述（由申请人提供）：当一个人不饿的时候吃能量密集的食物会导致超重和肥胖，这是一系列癌症的危险因素。过量食用这些食物的一个子集，如红肉或血糖指数高的食物，是癌症的另一个风险因素，与超重和肥胖分开。我们将通过其中一种或两种途径与癌症相关的食物称为促癌食物。该项目的目标是通过改善对促癌食物渴望的认知自我调节来降低癌症风险。 我们专注于对促癌食物的渴望，作为其消费的一个近端决定因素。渴望包括想要吃食物的主观感觉，寻找食物的动机，以及与食物相关的反复出现或侵入性想法。大量研究表明，即使在没有饥饿的情况下，渴望也是进食的一个强有力的预测因素。因此，加强一种简单，低成本和易于传播的工具来减少对促癌食物的渴望将促进癌症预防和相关研究。来自情感科学和社会神经科学的研究已经确定了认知自我调节策略， 能有效地减少渴望和相关的神经系统。这项工作主要集中在对其他食欲刺激的渴望上（例如，药物线索），并且刚刚开始研究对食物渴望的调节。我们实验室最近的结果验证了四种有效减少对高能量食物的渴望的策略。这项工作依赖于自我报告的渴望，这提供了一个经验的起点，但不证明自己的策略的有效性。因此，拟议项目的目标是提供额外的支持，认知自我调节的食物渴望使用其他措施以外的自我报告的有效性，并验证一个理论上接地的手段，以进一步提高这些策略的有效性-策略选择。这些目标将在一项研究的范围内通过两次会议实现。首先，参与者将被随机分配选择他们的监管策略或为他们选择一个。在第一次会议上， 当他们交替观看高能量食物的图像并调节他们对这些食物的反应时，他们自我报告的渴望和神经反应将被记录。这些数据将被用来研究食物调节对神经激活和自我报告的渴望的影响，并比较策略选择对这些措施的影响。在第二次会议中，参与者将在第一次会议后三天访问我们的行为实验室，在这一会议中，他们对能量密集型食物的实际摄入量将以自然和不引人注目的方式进行测量。两组之间的能量密集型食物摄入量的差异将提供饮食策略选择功效的行为测量。此外，第1阶段食物线索反应和调节期间的大脑活动将用于预测第2阶段的摄入量。心理学理论和先前的神经科学数据表明，神经活动，特别是内侧前额叶皮层的神经活动，可能解释了自我报告之外的能量密集食物摄入量的变化，并可能介导策略选择对摄入量的影响。