Biomarkers of ABCA1 mediated functions in Alzheimer's disease

ABCA1 介导的阿尔茨海默病功能的生物标志物

• 批准号: 10087701
• 负责人: Hussein N Yassine
• 金额: $ 27.82万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10087701
• 关键词: ATP binding cassette transporter 1; Address; Aging; Alzheimer' s Disease; Apolipoprotein E; Appointment; Area; Biological Markers; Cerebrospinal Fluid; Cholesterol; Clinic; Cognitive; Dementia; Diabetes Mellitus; Dyslipidemias; Elderly; Functional disorder; Funding; Genotype; Goals; Health; High Density Lipoprotein Cholesterol; High Density Lipoproteins; High Prevalence; Impaired cognition; Lipoproteins; Los Angeles; Mediating; Minority; Obesity; Participant; Patient Recruitments; Patients; Population; Proteins; Research; Resources; Risk; Risk Factors; Role; Time; apolipoprotein E-4; bilingualism; cardiovascular risk factor; follow-up; member; personalized medicine; programs; recruit; success

ABSTRACT In this project, the Yassine Lab is investigating the capacity of CSF lipoproteins as biomarkers. This project is providing unique information regarding pathophysiology of Alzheimer’s disease (AD) and identifying participants at risk of cognitive decline. We are requesting a supplemental support to increase the recruitment of Latinx participants. The support will also be beneficial for the planned longitudinal follow-up appointments of the participants that we have recruited to date. Critical to the success of this project is identifying patients with low HDL cholesterol dyslipidemia and cardiovascular (CVD) risk factors to assess the relationship of HDL function with cognitive decline. We propose to recruit participants from the Roybal Comprehensive Health Center in East Los Angeles. We have set up a research clinic at the Roybal Clinic and obtained approval from the facility director to recruit patients with diabetes and CVD risk factors. The Roybal Clinic is in an area of East Los Angeles that has a predominance of Latinx participants who have a higher prevalence of obesity, diabetes, dyslipidemia and CVD risk factors. To address this need, we are requesting supplemental funding to hire two new staff members with the primary role of assisting with the additional recruitment as well as retention activities of existing participants. Recruiting and retaining participants from the under-served minority population in East LA is critical to the success of aim 3. This effort will enrich and extend this program’s efforts to better represent the Latinx populations in dementia research.

抽象的 在这个项目中，亚辛实验室正在研究脑脊液脂蛋白作为生物标志物的能力。 该项目提供有关阿尔茨海默病病理生理学的独特信息 （AD）并识别有认知能力下降风险的参与者。 我们正在请求补充支持，以增加拉丁裔参与者的招募。 该支持还将有利于计划中的纵向后续任命 我们迄今为止已招募的参与者。该项目成功的关键是确定 低 HDL 胆固醇血脂异常患者和心血管 (CVD) 危险因素评估 HDL 功能与认知能力下降的关系。我们建议招募参与者 洛杉矶东部的皇家综合健康中心。我们设立了一个研究 Roybal 诊所的诊所，并获得设施主管的批准，可以招募患有以下疾病的患者 糖尿病和心血管疾病危险因素。罗伊巴尔诊所 (Roybal Clinic) 位于东洛杉矶地区，拥有 拉丁裔参与者中肥胖、糖尿病、 血脂异常和CVD危险因素。 为了满足这一需求，我们请求补充资金来雇用两名新员工 主要作用是协助额外的招聘和保留活动 现有参与者。招募和留住服务不足的少数群体的参与者 洛杉矶东部的人口对于目标 3 的成功至关重要。这项努力将丰富和扩展这一目标 该计划致力于在痴呆症研究中更好地代表拉丁裔人群。