Biomarkers of ABCA1 mediated functions in Alzheimer's disease

摘要 在这个项目中，亚辛实验室正在研究脑脊液脂蛋白作为生物标记物的能力。 该项目正在提供有关阿尔茨海默病病理生理学的独特信息 (Ad)并确定有认知衰退风险的参与者。 我们要求提供补充支持，以增加拉丁裔参与者的招募。 这项支助还将有利于计划的纵向后续任命 我们到目前为止已经招募的参与者。对这个项目的成功至关重要的是确定 低高密度脂蛋白血症患者与心血管(CVD)危险因素的评估 高密度脂蛋白功能与认知功能下降的关系我们建议从以下人员中招募参与者 东洛杉矶的罗伊巴尔综合健康中心。我们已经建立了一项研究 罗伊巴尔诊所的诊所，并获得设施主任的批准，招募患有 糖尿病和心血管疾病的危险因素。Roybal诊所位于洛杉矶东部的一个地区，那里有一个 拉丁裔参与者的优势，他们有较高的肥胖、糖尿病、 血脂异常和心血管疾病的危险因素。 为了满足这一需要，我们正在申请补充资金，以雇用两名新工作人员。 其主要作用是协助额外的招聘和保留活动 现有参与者。从服务不足的少数群体中招募和留住参与者 东洛杉矶的人口对AIM 3的成功至关重要。这一努力将丰富和扩展这一点 该计划的努力，以更好地代表拉丁裔人口在痴呆症研究。

ABSTRACT In this project, the Yassine Lab is investigating the capacity of CSF lipoproteins as biomarkers. This project is providing unique information regarding pathophysiology of Alzheimer’s disease (AD) and identifying participants at risk of cognitive decline. We are requesting a supplemental support to increase the recruitment of Latinx participants. The support will also be beneficial for the planned longitudinal follow-up appointments of the participants that we have recruited to date. Critical to the success of this project is identifying patients with low HDL cholesterol dyslipidemia and cardiovascular (CVD) risk factors to assess the relationship of HDL function with cognitive decline. We propose to recruit participants from the Roybal Comprehensive Health Center in East Los Angeles. We have set up a research clinic at the Roybal Clinic and obtained approval from the facility director to recruit patients with diabetes and CVD risk factors. The Roybal Clinic is in an area of East Los Angeles that has a predominance of Latinx participants who have a higher prevalence of obesity, diabetes, dyslipidemia and CVD risk factors. To address this need, we are requesting supplemental funding to hire two new staff members with the primary role of assisting with the additional recruitment as well as retention activities of existing participants. Recruiting and retaining participants from the under-served minority population in East LA is critical to the success of aim 3. This effort will enrich and extend this program’s efforts to better represent the Latinx populations in dementia research.