Biomarkers of ABCA1 mediated functions in Alzheimer's disease

摘要 在这个项目中，Yassine实验室正在研究CSF脂蛋白作为生物标志物的能力。 该项目提供了关于阿尔茨海默病病理生理学的独特信息 (AD)以及识别有认知能力下降风险的参与者。 我们正在请求补充支持，以增加拉丁美洲参与者的招募。 这种支持也将有利于计划中的纵向随访， 迄今为止，我们招募的参与者。这个项目成功的关键是确定 低HDL胆固醇患者血脂异常和心血管（CVD）危险因素评估 HDL功能与认知功能下降的关系。我们建议招募以下人士参加 位于东洛杉矶的罗伊巴尔综合健康中心我们已经建立了一个研究 Roybal诊所的诊所，并获得了设施主任的批准，招募患者， 糖尿病和CVD危险因素。罗伊巴尔诊所位于东洛杉矶的一个地区， 拉丁裔参与者占主导地位，他们的肥胖、糖尿病 血脂异常和CVD危险因素。 为了满足这一需求，我们正在申请补充资金，以雇用两名新工作人员 其主要作用是协助开展额外的招聘和留用活动， 现有参与者。从服务不足的少数群体中征聘和留住参与者 洛杉矶东部的人口对目标3的成功至关重要。这一努力将丰富和扩展这一 该计划的努力，以更好地代表拉丁裔人口在痴呆症研究。

ABSTRACT In this project, the Yassine Lab is investigating the capacity of CSF lipoproteins as biomarkers. This project is providing unique information regarding pathophysiology of Alzheimer’s disease (AD) and identifying participants at risk of cognitive decline. We are requesting a supplemental support to increase the recruitment of Latinx participants. The support will also be beneficial for the planned longitudinal follow-up appointments of the participants that we have recruited to date. Critical to the success of this project is identifying patients with low HDL cholesterol dyslipidemia and cardiovascular (CVD) risk factors to assess the relationship of HDL function with cognitive decline. We propose to recruit participants from the Roybal Comprehensive Health Center in East Los Angeles. We have set up a research clinic at the Roybal Clinic and obtained approval from the facility director to recruit patients with diabetes and CVD risk factors. The Roybal Clinic is in an area of East Los Angeles that has a predominance of Latinx participants who have a higher prevalence of obesity, diabetes, dyslipidemia and CVD risk factors. To address this need, we are requesting supplemental funding to hire two new staff members with the primary role of assisting with the additional recruitment as well as retention activities of existing participants. Recruiting and retaining participants from the under-served minority population in East LA is critical to the success of aim 3. This effort will enrich and extend this program’s efforts to better represent the Latinx populations in dementia research.