HP3JC Motoman Robotic Arm and CombiFlash Automated Chromatography Systems

描述(由申请人提供)：神经退行性疾病药物发现实验室(LDDN)是一个与全国各地的实验室合作进行高通量筛选和药物化学项目的药物发现中心，重点是神经退行性疾病。这项提案的目的是：1)要求升级我们的自动化集成机器人系统，用他们的新Motoman机械臂取代Beckman Coulter不再支持的虎鲸机械臂。这种新的ARM以及与现有设备的集成将大大提高我们的自动化能力，使其速度更快、能力更强。2)申请两套CombiFlash RF-75型自动闪光层析系统，以取代陈旧和故障的现有层析系统。通过NINDS U24资助的国家神经变性药物发现中心(NCDDN)高通量筛查和药物化学计划，LDDN每年有五个新的合作项目得到支持。此外，由其他NIH和基金会资助的每年5-10个高通量筛选合作项目也使用这种自动化设备，将大大受益。使用这一要求的设备的长期目标是促进确定神经退行性疾病和其他疾病的新疗法。我们还确定了可供研究界使用的新工具化合物。 公共卫生相关性：我们专注于开发治疗神经退行性疾病和其他疾病的新疗法。升级的自动化和集成机器人系统将允许初步识别可以进一步优化为候选药物的化合物，自动化合物纯化系统将允许在项目的药物化学优化阶段进行更高效的化合物合成。所要求的设备是替换我们设施中陈旧和过时的现有设备。

DESCRIPTION (provided by applicant): The Laboratory for Drug Discovery for Neurodegeneration (LDDN) is a center that collaborates with laboratories from around the country for high throughput screening and medicinal chemistry projects for drug discovery with a focus on neurodegenerative diseases. The purpose of this proposal is: 1) to request an upgrade of our automated integrated robotic system to replace a robotic Orca arm that is no longer supported by Beckman Coulter with their new Motoman robotic arm. This new arm and integration with existing equipment will greatly improve our automation capabilities with its much higher speed and greater capabilities. 2) to request two CombiFlash Rf-75 Automated Flash Chromatography Systems to replace existing chromatography systems that are old and failing. Five new collaborative projects per year at LDDN are supported through a NINDS U24 grant National Center for Drug Discovery for Neurodegeneration (NCDDN) program for high throughput screening and medicinal chemistry. In addition, 5-10 collaborative projects per year for high throughput screening that are supported through other NIH and foundation grants also use this automation equipment and will greatly benefit. Long term objective for use of this requested equipment is to facilitate identification of new therapeutics for neurodegenerative and other diseases. We also identify new tool compounds that can be used by the research community. PUBLIC HEALTH RELEVANCE: We are focused on developing novel therapeutics for neurodegenerative and other diseases. An upgraded automated and integrated robotics system will allow for the initial identification of compounds that can be further optimized to be a drug candidate and the automated compound purification systems allow for more efficient compound synthesis during the medicinal chemistry optimization phase of a project. Requested equipment is to replace old and obsolete existing equipment at our facility.