Direct Write Microfabrication Platform for Biomedical Research

用于生物医学研究的直写微加工平台

• 批准号: 7794375
• 负责人: Lance C Kam
• 金额: $ 17.98万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-15 至 2011-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794375
• 关键词: Area; Arts; Biomedical Research; Cell Culture Techniques; Cells; Communities; Complement; Complex; Diagnostic; Engineering; Environment; Equipment; Interest Group; Lasers; Masks; Microfabrication; Miniaturization; Pattern; Process; Research; Research Personnel; Resources; Scanning; Science; Surface; System; Systems Analysis; Techniques; Universities; Work; Writing; cost; design; interest; lithography; meetings; research study

DESCRIPTION (provided by applicant): Microscale systems have a strong and increasing presence in basic and applied biomedical research. The ability to manipulate and define an experimental system at the scale of micrometers has revealed much about how cells interact with their complex environment. Conversely, miniaturization of biomolecular analyses systems hold the promise of transportable and effective diagnostics. We are proposing to purchase a microfabrication platform to accelerate research into these fields on the Columbia University campus. This area of research has seen a tremendous increase in recent years on this campus, and currently our need for sophisticated microfabrication is not met through resources on campus or in the local area. Specifically, we have a need for fabrication techniques that provide patterning of micrometer scale features over areas sufficiently large to carry out contemporary cell culture experiments. The platform we are proposing is a state-of-the-art laser lithography platform, with a minimum feature size of 1 micrometer. In addition to providing much needed capacity, this platform offers several key capabilities. In this approach, a laser is scanned across a working surface, directly exposing designated regions of the substrate for later processing. By circumventing the need for a photolithographic mask, this approach shortens the design/analysis cycle for micropatterning, and dramatically reduces the cost of each iteration. In addition, control over the laser intensity makes possible a range of advance patterning techniques for making complex surfaces. This apparatus will complement the facilities currently in place on the Columbia University campus, providing an important resource for this community. The team of investigators in this proposed project represents a wide range of biomedical science and engineering interests. By making this capacity available to this diverse group of interests, the proposed equipment will have a wide impact on accelerating research.

描述(由申请人提供)：微尺度系统在基础和应用生物医学研究中具有强大的和日益增长的存在。在微米尺度上操纵和定义实验系统的能力揭示了细胞如何与复杂环境相互作用的许多问题。相反，生物分子分析系统的小型化为可运输和有效的诊断带来了希望。我们建议购买一个微制造平台，以加快哥伦比亚大学校园对这些领域的研究。近年来，这一领域的研究在这个校园里有了巨大的增长，目前我们对尖端微制造的需求并不是通过校园或当地的资源来满足的。具体地说，我们需要在足够大的区域上提供微米级特征的图案化的制造技术，以进行当代细胞培养实验。我们提出的平台是最先进的激光光刻平台，最小特征尺寸为1微米。除了提供急需的容量外，该平台还提供了几个关键功能。在这种方法中，激光扫描工作表面，直接曝光衬底的指定区域，以供以后处理。通过避免对光刻掩模的需要，这种方法缩短了微图案化的设计/分析周期，并显著降低了每次迭代的成本。此外，对激光强度的控制使制造复杂表面的一系列先进的图案化技术成为可能。这一设备将补充哥伦比亚大学校园现有的设施，为这个社区提供重要的资源。这一拟议项目中的研究团队代表了生物医学科学和工程学的广泛兴趣。通过将这种能力提供给这一不同的利益群体，拟议的设备将对加速研究产生广泛影响。