NHMRC Research Fellowship. Genetic modification and differentiation of human pluripotent stem cells: creating tools for regenerative medicine and models for disease

NHMRC 研究奖学金。

• 批准号: nhmrc : 1002154
• 负责人: Prof Andrew Elefanty
• 金额: $ 50.5万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nhmrc-research-fellowship-models-disease/108779
• 关键词: NHMRC; Research; Fellowship.; Genetic; modification

Human embryonic stem cells (hESCs) can form all the cell types in the body. Cells made from hESCs could be used to test new drugs prior to trials in patients and eventually to replace tissues damaged through accident or disease. My laboratory is turning hESCs into blood, heart and insulin producing cells. We can genetically modify such that the cells fluoresce whenever they develop into these cell types. These 'glowing' hESC lines help us to make different cell types more efficiently.

人类胚胎干细胞（human embryonic stem cells，hESCs）是一种可分化为多种细胞类型的细胞。由hESC制成的细胞可用于在患者试验之前测试新药，并最终取代因事故或疾病而受损的组织。我的实验室正在将hESC转化为血液，心脏和胰岛素生产细胞。我们可以通过基因改造，使细胞在发育成这些细胞类型时发出荧光。这些“发光”的hESC系帮助我们更有效地制造不同的细胞类型。