Transcriptional regulation of definitive hematopoietic development in humans

人类最终造血发育的转录调控

• 批准号: nhmrc : GNT1129861
• 负责人: Prof Andrew Elefanty
• 金额: $ 80万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcriptional-regulation-definitive-development-humans/1347782
• 关键词: Transcriptional; regulation; definitive; hematopoietic; development

Blood stem cell transplantation is a vital therapy for patients with leukaemia following chemotherapy or for patients with bone marrow failure. Because many patients lack a donor, there is a need for an alternate source of stem cells, such as human pluripotent stem cells. During development, blood cells are formed from the blood vessel wall, or endothelium. In this project, we will study the regulation of this process in order to more efficiently make human blood cells in the laboratory.

造血干细胞移植是白血病化疗后或骨髓衰竭患者的重要治疗方法。由于许多患者缺乏供体，因此需要替代干细胞来源，例如人类多能干细胞。在发育过程中，血细胞由血管壁或内皮形成。在这个项目中，我们将研究这一过程的调节，以便在实验室中更有效地制造人类血细胞。