Developmental neurotoxicity of organophosphate and novel brominated flame retardants in children
有机磷酸酯和新型溴化阻燃剂对儿童的发育神经毒性
基本信息
- 批准号:10247374
- 负责人:
- 金额:$ 71.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-19 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:12 year oldAddressAffectAnatomyAttention deficit hyperactivity disorderBehaviorBirthBrainBrain imagingCarpetChemical ExposureChildChildhoodCognitionCohort StudiesCommunitiesDNA MethylationDataDevelopmentElectronicsEmbryonic DevelopmentEnvironmentEstrogen AntagonistsExposure toFlame RetardantsGene ExpressionHealthHomeHumanIn VitroInvestigationLanguageMeasuresMediatingMemoryMissionModalityNeuronal DifferentiationNeuronsNeurotoxinsOrganophosphatesOutcomeOutcome MeasurePentasPersonsPhasePolicy MakerPregnancyPregnant WomenPrevention strategyProblem behaviorPublic HealthRegulationReportingResearchSamplingScientistSerumStructureSymptomsTelomere-Binding ProteinsTestingTextilesThyroid HormonesThyrotropinThyroxineToxic effectToxicologyTriiodothyronineUnited States National Institutes of HealthUrineanalogandrogenicbasebehavior testcognitive abilitycognitive functioncognitive testingcohortconsumer productdevelopmental neurotoxicityearly adolescenceenvironmental chemicalepidemiology studyexecutive functionexperimental studyexposure pathwayfollow-upin vivoinnovationinorganic phosphateneural networkneurobehaviorneurobehavioralneurochemistryneuroimagingneurotoxicitynovelpolybrominated diphenyl etherpolyurethane foampostnatalprenatalskillswhite matter
项目摘要
Project Summary
Toxicological and epidemiologic studies have shown developmental neurotoxicity of polybrominated diphenyl
ethers (PBDEs), a group of flame retardants (FRs) widely used in the U.S. and elsewhere. With the phase-out
of PBDEs from the market since 2004, replacement FRs, including organophosphate flame retardants (OPFRs)
and novel brominated flame retardants (NBFRs), are increasingly added to consumer products to meet
flammability requirement. Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and Firemaster® 550 (FM 550) are
the most commonly used replacement FRs. TDCPP, also referred to as “chlorinated tris”, is an OPFR once
added to children’s sleepwear in the 1970s but later removed because of toxicity concerns.
Triphenylphosphate (TPP) and various TPP analogs are OPFR components in FM 550, while 2-ethylhexyl-
2,3,4,5-tetrabromobenzoate (TBB) and bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH) are NBFR
components in FM 550. TDCPP, TPP and FM 550 have been reported to alter thyroid hormone levels, reduce
neuronal viability and replication, alter neuronal differentiation, cause abnormal embryogenesis and
development, affect neurobehavior, and change gene expression levels and DNA methylation in experimental
studies. Compared with experimental study evidence of OPFRs and NBFRs, there are significant gaps in our
understanding of their developmental neurotoxicity in humans. We propose to examine developmental
neurotoxicity of OPFRs and NBFRs using the Cincinnati-based Health Outcomes and Measures of the
Environment (HOME) Study, an existing birth cohort of 410 children from prenatal to 12 years of age, with
prenatal and postnatal exposure assessment, thyroid hormones, cognitive and behavioral tests, and
neuroimaging data. We hypothesize that prenatal and postnatal exposures to OPFRs and NBFRs are
associated with: 1) altered thyroid hormone levels in maternal, cord, and childhood serum samples; 2)
decreased child cognitive function; 3) poorer child neurobehavioral functioning; and 4) adverse impact on brain
structure, organization, and function identified by neuroimaging at age 12 years. The proposed research will be
the first to comprehensively study developmental neurotoxicity of both OPFRs and NBFRs in children.
Addressing neuroendocrinological, neurobehavioral, and neuroimaging aspects of brain development is highly
innovative for this investigation. The findings will be of critical value to scientific community and policy makers
evaluating potential impact of current-use replacement FRs on developing brain. The research is highly
relevant to the National Institutes of Health mission to identify potential chemical exposures that disrupt brain
development and provide critical data to inform prevention strategies.
项目概要
毒理学和流行病学研究表明多溴联苯具有发育神经毒性
醚类 (PBDE) 是一组在美国和其他地方广泛使用的阻燃剂 (FR)。随着逐步淘汰
自 2004 年以来市场上 PBDE 的数量、替代 FR,包括有机磷酸酯阻燃剂 (OPFR)
和新型溴化阻燃剂 (NBFR) 越来越多地添加到消费品中,以满足
可燃性要求。磷酸三(1,3-二氯-2-丙基)酯 (TDCPP) 和 Firemaster® 550 (FM 550)
最常用的替代 FR。 TDCPP,也称为“氯化三羟甲基氨基甲烷”,是一种 OPFR
20 世纪 70 年代,它被添加到儿童睡衣中,但后来由于毒性问题而被移除。
磷酸三苯酯 (TPP) 和各种 TPP 类似物是 FM 550 中的 OPFR 成分,而 2-乙基己基-
2,3,4,5-四溴苯甲酸酯 (TBB) 和双(2-乙基己基)-2,3,4,5-四溴邻苯二甲酸酯 (TBPH) 属于 NBFR
FM 550 中的成分。据报道,TDCPP、TPP 和 FM 550 可以改变甲状腺激素水平,降低
神经元活力和复制,改变神经元分化,导致异常胚胎发生和
发育、影响神经行为、改变实验中的基因表达水平和 DNA 甲基化
研究。与 OPFR 和 NBFR 的实验研究证据相比,我们的研究存在显着差距
了解它们对人类的发育神经毒性。我们建议检查发育
使用基于辛辛那提的健康结果和措施评估 OPFR 和 NBFR 的神经毒性
环境(家庭)研究,现有出生队列,包括 410 名从产前到 12 岁的儿童,其中
产前和产后暴露评估、甲状腺激素、认知和行为测试,以及
神经影像数据。我们假设产前和产后暴露于 OPFR 和 NBFR
与以下因素相关:1) 母体、脐带和儿童血清样本中甲状腺激素水平的改变; 2)
儿童认知功能下降; 3)儿童神经行为功能较差; 4)对大脑的不利影响
12 岁时通过神经影像学确定结构、组织和功能。拟议的研究将是
第一个全面研究 OPFR 和 NBFR 对儿童的发育神经毒性。
解决大脑发育的神经内分泌学、神经行为学和神经影像学方面的问题非常重要
本次调查具有创新性。研究结果对科学界和政策制定者具有至关重要的价值
评估当前使用的替代 FR 对发育中的大脑的潜在影响。该研究具有很高的
与美国国立卫生研究院的使命相关,即识别破坏大脑的潜在化学物质暴露
开发并提供关键数据来为预防策略提供信息。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Aimin Chen其他文献
Aimin Chen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Aimin Chen', 18)}}的其他基金
Philadelphia Regional Center for Children's Environmental Health
费城儿童环境健康区域中心
- 批准号:
10838756 - 财政年份:2021
- 资助金额:
$ 71.1万 - 项目类别:
Philadelphia Regional Center for Children’s Environmental Health
费城儿童环境健康区域中心
- 批准号:
10534772 - 财政年份:2021
- 资助金额:
$ 71.1万 - 项目类别:
Impact of pre- and postnatal chemical mixture exposures on child neurobehavior and neuroimaging
产前和产后化学混合物暴露对儿童神经行为和神经影像的影响
- 批准号:
10226761 - 财政年份:2021
- 资助金额:
$ 71.1万 - 项目类别:
Philadelphia Regional Center for Children’s Environmental Health
费城儿童环境健康区域中心
- 批准号:
10307396 - 财政年份:2021
- 资助金额:
$ 71.1万 - 项目类别:
Impact of pre- and postnatal chemical mixture exposures on child neurobehavior and neuroimaging
产前和产后化学混合物暴露对儿童神经行为和神经影像的影响
- 批准号:
10620185 - 财政年份:2021
- 资助金额:
$ 71.1万 - 项目类别:
Developmental neurotoxicity of organophosphate and novel brominated flame retardants in children
有机磷酸酯和新型溴化阻燃剂对儿童的发育神经毒性
- 批准号:
10394972 - 财政年份:2021
- 资助金额:
$ 71.1万 - 项目类别:
Impact of pre- and postnatal chemical mixture exposures on child neurobehavior and neuroimaging
产前和产后化学混合物暴露对儿童神经行为和神经影像的影响
- 批准号:
10441308 - 财政年份:2021
- 资助金额:
$ 71.1万 - 项目类别:
Longitudinal study of exposure to PBDEs and PFCs and child neurobehavior
PBDEs 和 PFCs 暴露与儿童神经行为的纵向研究
- 批准号:
8668058 - 财政年份:2011
- 资助金额:
$ 71.1万 - 项目类别:
Longitudinal study of exposure to PBDEs and PFCs and child neurobehavior
PBDEs 和 PFCs 暴露与儿童神经行为的纵向研究
- 批准号:
8159870 - 财政年份:2011
- 资助金额:
$ 71.1万 - 项目类别:
Longitudinal study of exposure to PBDEs and PFCs and child neurobehavior
PBDEs 和 PFCs 暴露与儿童神经行为的纵向研究
- 批准号:
8462975 - 财政年份:2011
- 资助金额:
$ 71.1万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 71.1万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 71.1万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 71.1万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 71.1万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 71.1万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 71.1万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 71.1万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 71.1万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 71.1万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 71.1万 - 项目类别:
Research Grant














{{item.name}}会员




