Longitudinal study of exposure to PBDEs and PFCs and child neurobehavior

PBDEs 和 PFCs 暴露与儿童神经行为的纵向研究

• 批准号: 8668058
• 负责人: Aimin Chen
• 金额: $ 54.98万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-23 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8668058
• 关键词: 3 year old; 5 year old; 8 year old; Acids; Address; Adverse effects; Age; Animals; Attention; Behavior; Biological; Birth; Blood; Brain; Chemical Exposure; Chemicals; Child; Clinical; Cognition; Cohort Studies; Data; Development; Dose; Dust; Environment; Environmental Exposure; Environmental Health; Epidemiologic Studies; Exhibits; Exposure to; Family; Flame Retardants; Funding; Future; Goals; Health; Hormonal; House Dust; Human; Human Milk; Hyperactive behavior; Impaired cognition; Impairment; Individual; Infant; Learning; Longitudinal Studies; Maternal Exposure; Measures; Memory; Mission; Motor Skills; National Institute of Environmental Health Sciences; Neurotoxins; Oral cavity; Organic Chemicals; Outcome Measure; Phase; Placenta; Predisposition; Pregnancy; Pregnant Women; Prevention; Prospective Studies; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Research Project Grants; Risk; Role; Route; Sampling; Scientist; Serum; Staging; Sulfonic Acids; Testing; Thyroid Function Tests; Thyroid Hormones; Time; Toxic Environmental Substances; Toxic effect; United States National Institutes of Health; Visit; Woman; base; cognitive function; cohort; consumer product; design; developmental neurotoxicity; executive function; experience; fetal; follow-up; high risk; human study; in utero; maternal serum; neurobehavior; neurobehavioral; neurodevelopment; novel; perfluorooctane; phenyl ether; pollutant; postnatal; prenatal; response; sample collection; surfactant

DESCRIPTION (provided by applicant): Polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl chemicals (PFCs, including perfluorooctane sulfonic acid [PFOS] and perfluorooctanoic acid [PFOA]) are persistent organic chemicals that were introduced several decades ago. Animal studies and limited human studies of PBDEs and PFCs have found evidence for developmental neurotoxicity in children, including thyroid hormone disruption, hyperactivity, delay in neuromotor maturation, and impaired cognition. Although these chemicals are being phased out, humans will still be exposed to PBDEs and PFCs in the environment for decades because these compounds were widely used as flame retardants and surfactants in consumer products. To address the potential adverse health risks of PBDEs and PFCs on fetal, infant, and child neurobehavioral development, the investigators will systematically examine their associations with thyroid function, cognition, learning and memory, motor skills, attention and executive function, and behavior from age 1 to 8 years. The long-term goal is to quantify the roles of PBDE and PFC exposures on child neurobehavior and to inform future prevention efforts. The three specific aims are to: 1) investigate the associations between prenatal and postnatal exposures to PBDEs and thyroid hormones and child neurobehavior; 2) examine the associations between prenatal and postnatal exposures to PFCs and thyroid hormones and child neurobehavior; and 3) assess the environmental exposure to PBDEs through transplacental and lactational routes and indoor dust in children. The investigators will test these associations in the Health Outcomes and Measures of the Environment (HOME) Study, an ongoing NIEHS-funded longitudinal birth cohort of 398 women and their children with current follow-up to 5 years. The investigators will extend the cohort to include an age 8 follow-up clinical visit with comprehensive neurobehavior assessments. The investigators will examine the PBDE and PFC exposures at different developmental stages (in utero at 16 weeks of gestation, ages 3, 5, and 8 years) and child neurobehavior measured at 1, 2, 3, 4, 5, and 8 years using stored serum samples. This longitudinal study will allow the investigators to determine the dose response, windows of susceptibility, and persistence of the association. We will also examine the contribution of PBDE exposures from house dust in a subset of children who have complete sample collection of maternal serum and child serum at 1, 2, and 3 years, along with extensive measures of mouthing behaviors. This research is closely related to the NIH mission to investigate prevalent environmental toxicants and children's neurodevelopment.

描述（由申请人提供）：多溴二苯醚 (PBDE) 和全氟烷基化学品 (PFC，包括全氟辛烷磺酸 [PFOS] 和全氟辛酸 [PFOA]) 是几十年前引入的持久性有机化学品。对 PBDE 和 PFC 的动物研究和有限的人体研究发现了儿童发育神经毒性的证据，包括甲状腺激素破坏、过度活跃、神经运动成熟延迟和认知受损。尽管这些化学物质正在被逐步淘汰，但几十年来，人类仍然会接触环境中的多溴二苯醚和全氟碳化物，因为这些化合物被广泛用作消费品中的阻燃剂和表面活性剂。为了解决 PBDE 和 PFC 对胎儿、婴儿和儿童神经行为发育的潜在不利健康风险，研究人员将系统地检查它们与甲状腺功能、认知、学习和记忆、运动技能、注意力和执行功能以及 1 至 8 岁儿童行为的关系。长期目标是量化 PBDE 和 PFC 暴露对儿童神经行为的作用，并为未来的预防工作提供信息。这三个具体目标是： 1) 调查产前和产后接触 PBDE 和甲状腺激素与儿童神经行为之间的关系； 2) 检查产前和产后接触 PFC 和甲状腺激素与儿童神经行为之间的关联； 3) 评估儿童通过胎盘和哺乳途径以及室内灰尘对多溴二苯醚的环境暴露。研究人员将在健康结果和环境措施 (HOME) 研究中测试这些关联，该研究是一项由 NIEHS 资助、持续进行的纵向出生队列，共有 398 名妇女及其子女，目前随访期长达 5 年。研究人员将扩大队列范围，纳入 8 岁的随访临床访问，并进行全面的神经行为评估。研究人员将使用储存的血清样本检查不同发育阶段（妊娠 16 周的子宫内、3、5 和 8 岁）的 PBDE 和 PFC 暴露情况，以及 1、2、3、4、5 和 8 岁时测量的儿童神经行为。这项纵向研究将使研究人员能够确定剂量反应、敏感性窗口和关联的持续性。我们还将研究一组儿童中室内灰尘中 PBDE 暴露的影响，这些儿童在 1、2 和 3 岁时收集了完整的母体血清和儿童血清样本，并进行了广泛的口腔行为测量。这项研究与美国国立卫生研究院调查普遍环境毒物和儿童神经发育的使命密切相关。