Urban air pollution and neurobehavioral trajectories in the ABCD study
ABCD 研究中的城市空气污染和神经行为轨迹
基本信息
- 批准号:10256619
- 负责人:
- 金额:$ 63.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-09 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:10 year old12 year oldAddressAdolescenceAdolescentAdultAdverse effectsAffectAgeAirAir PollutantsAir PollutionAmericanAnimalsAreaBehavior assessmentBehavioralBrainCaliberCarbonChargeChildChildhoodCitiesCognitiveCommunitiesConflict (Psychology)Corpus striatum structureCrimeDataDevelopmentDevelopmental CourseDorsalEmotionalEmotionsEnrollmentEnvironmental Risk FactorEpidemiologyExposure toFamilyGeographic LocationsGeographyHealthHeterogeneityHumanHybridsIndividualInterventionKnowledgeLifeLiteratureLongitudinal StudiesMagnetic Resonance ImagingMapsMethodologyModelingMorphologyNeighborhoodsNeurocognitiveNeuroepidemiologyNeurotoxinsNitratesNitrogen DioxideOptimum PopulationsOutcomeOutcome MeasureOzonePoliciesPopulationPopulation CharacteristicsPopulation HeterogeneityPredispositionPrefrontal CortexPregnancyPreventionPrevention programProcessPublic HealthRecording of previous eventsRegulationResolutionRestRisk FactorsRoleSamplingScienceSex DifferencesSocial EnvironmentSocioeconomic StatusStructureSulfateSurfaceTimeViolenceVisitVulnerable PopulationsYouthbasebehavior testboysbrain behaviorbrain morphologycognitive controlcognitive developmentcohortdesigndevelopmental neurotoxicitydisadvantaged backgroundearly adolescenceearly childhoodemerging adultemotional behaviorexecutive functionfine particlesfollow-upgirlsgray matterimprovedinterestintervention programmulti-ethnicmultimodalityneurobehavioralneuroimagingneurotoxicneurotoxicityneurotoxicologynovelparental involvementparticlepollutantpreadolescenceprenatalprospectiveprotective factorsrecruitresiliencesexsexual dimorphismsocialsocial factorssociodemographicsspatiotemporaltoolurban areawhite matter
项目摘要
Project Summary
Fine particulate matter (aerodynamic diameter<2.5 μm; PM2.5) is a novel and ubiquitous environmental
neurotoxin affecting neurobehavioral development of millions of American children living in urban areas.
However, our review points to several major methodological limitations and critical knowledge gaps in the extant
literature, including: 1) the lack of studies with longitudinal brain and behavior assessments; 2) relatively small
samples from localized geographical areas; 3) little to no information on long-term cumulative and/or differential
timing of exposure across development; and 4) remaining questions regarding the neurotoxicity of PM2.5
exposure on critical neurobehavioral processes that continue to mature across adolescence. Although animal
neurotoxicology studies have highlighted the importance of sex, there is only limited epidemiologic evidence for
sex difference in PM2.5 neurotoxicity in children. Moreover, brain development is also shaped by family- and
community-level social factors, but whether and how air pollution neurotoxicity interacts with the social context
remains unclear. This application will leverage the nationwide longitudinal
Development (ABCD) study of 9- and 10-year-olds (N=11,873)
Adolescent Brain Cognitive
to examine prenatal and childhood air pollution
exposure effects on neurobehavioral development in boys and girls across 21 U.S. cities. ABCD outcome
measures are anchored on the transition to early adolescence because neuromaturation continues from
childhood through early adulthood, making such developmental transition periods potentially more vulnerable to
environmental insults. Our primary exposure of interest is PM2.5, but advances in well-validated spatiotemporal
modeling tools will also allow us to explore neurotoxicity of PM composition and other gaseous pollutants (i.e.
NO2, O3). Given the reconstructed exposure histories from gestation to childhood to early-adolescence, we will:
(a) determine long-term cumulative exposure effects; and (b) examine differential exposure effects across
sensitive time windows to better define PM2.5 neurotoxicity on executive functioning (EF) and emotional
behaviors from ages 9 to 12 years-old (Aim 1); and also understand how the resulting neurotoxicity influences
structural and functional brain development, including brain morphology, white matter microstructure, brain
activity at rest and during EF and emotion-focused tasks, and functional connectivity of large-scale networks
(Aim 2). In Aim 3, we will evaluate if children are more susceptible to PM2.5 effects based on: a) sex and SES;
and b) family- and neighborhood-level contextual risk and protective factors. This application will advance our
understanding of air pollution neurotoxicity on adolescent brains, as well as how exposure effects may vary
across sensitive time windows of development and/or differ by individual susceptibility. The resulting new
knowledge will contribute to sciences-based air pollution regulations to protect public health, but also inform the
development of preventions and interventions targeting sensitive time-windows and vulnerable populations.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Megan Marie Herting其他文献
Megan Marie Herting的其他文献
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{{ truncateString('Megan Marie Herting', 18)}}的其他基金
The role of air pollution in emotional neurodevelopment and risk for psychiatric disorders
空气污染在情绪神经发育和精神疾病风险中的作用
- 批准号:
10445289 - 财政年份:2020
- 资助金额:
$ 63.6万 - 项目类别:
Urban air pollution and neurobehavioral trajectories in the ABCD study
ABCD 研究中的城市空气污染和神经行为轨迹
- 批准号:
10445343 - 财政年份:2020
- 资助金额:
$ 63.6万 - 项目类别:
Urban air pollution and neurobehavioral trajectories in the ABCD study
ABCD 研究中的城市空气污染和神经行为轨迹
- 批准号:
10653053 - 财政年份:2020
- 资助金额:
$ 63.6万 - 项目类别:
The role of air pollution in emotional neurodevelopment and risk for psychiatric disorders
空气污染在情绪神经发育和精神疾病风险中的作用
- 批准号:
10267189 - 财政年份:2020
- 资助金额:
$ 63.6万 - 项目类别:
The role of air pollution in emotional neurodevelopment and risk for psychiatric disorders
空气污染在情绪神经发育和精神疾病风险中的作用
- 批准号:
10653023 - 财政年份:2020
- 资助金额:
$ 63.6万 - 项目类别:
Urban air pollution and neurobehavioral trajectories in the ABCD study
ABCD 研究中的城市空气污染和神经行为轨迹
- 批准号:
10045490 - 财政年份:2020
- 资助金额:
$ 63.6万 - 项目类别:
The Role of Androgens in Amygdala Subnuclei Development Across Human Adolescence
雄激素在人类青春期杏仁核亚核发育中的作用
- 批准号:
9388088 - 财政年份:2017
- 资助金额:
$ 63.6万 - 项目类别:
The Influence of Fetal Testosterone on Emotional Processing, Amydala Neurocircuitry, and Risk for Affective Disorders in Childhood
胎儿睾酮对情绪处理、杏仁核神经回路和儿童时期情感障碍风险的影响
- 批准号:
9330938 - 财政年份:2016
- 资助金额:
$ 63.6万 - 项目类别:
8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA
8/21 ABCD-美国联盟:CHLA 研究项目现场
- 批准号:
10157918 - 财政年份:2015
- 资助金额:
$ 63.6万 - 项目类别:
8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA
8/21 ABCD-美国联盟:CHLA 研究项目现场
- 批准号:
9980721 - 财政年份:2015
- 资助金额:
$ 63.6万 - 项目类别:
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