Urban air pollution and neurobehavioral trajectories in the ABCD study
ABCD 研究中的城市空气污染和神经行为轨迹
基本信息
- 批准号:10256619
- 负责人:
- 金额:$ 63.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-09 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:10 year old12 year oldAddressAdolescenceAdolescentAdultAdverse effectsAffectAgeAirAir PollutantsAir PollutionAmericanAnimalsAreaBehavior assessmentBehavioralBrainCaliberCarbonChargeChildChildhoodCitiesCognitiveCommunitiesConflict (Psychology)Corpus striatum structureCrimeDataDevelopmentDevelopmental CourseDorsalEmotionalEmotionsEnrollmentEnvironmental Risk FactorEpidemiologyExposure toFamilyGeographic LocationsGeographyHealthHeterogeneityHumanHybridsIndividualInterventionKnowledgeLifeLiteratureLongitudinal StudiesMagnetic Resonance ImagingMapsMethodologyModelingMorphologyNeighborhoodsNeurocognitiveNeuroepidemiologyNeurotoxinsNitratesNitrogen DioxideOptimum PopulationsOutcomeOutcome MeasureOzonePoliciesPopulationPopulation CharacteristicsPopulation HeterogeneityPredispositionPrefrontal CortexPregnancyPreventionPrevention programProcessPublic HealthRecording of previous eventsRegulationResolutionRestRisk FactorsRoleSamplingScienceSex DifferencesSocial EnvironmentSocioeconomic StatusStructureSulfateSurfaceTimeViolenceVisitVulnerable PopulationsYouthbasebehavior testboysbrain behaviorbrain morphologycognitive controlcognitive developmentcohortdesigndevelopmental neurotoxicitydisadvantaged backgroundearly adolescenceearly childhoodemerging adultemotional behaviorexecutive functionfine particlesfollow-upgirlsgray matterimprovedinterestintervention programmulti-ethnicmultimodalityneurobehavioralneuroimagingneurotoxicneurotoxicityneurotoxicologynovelparental involvementparticlepollutantpreadolescenceprenatalprospectiveprotective factorsrecruitresiliencesexsexual dimorphismsocialsocial factorssociodemographicsspatiotemporaltoolurban areawhite matter
项目摘要
Project Summary
Fine particulate matter (aerodynamic diameter<2.5 μm; PM2.5) is a novel and ubiquitous environmental
neurotoxin affecting neurobehavioral development of millions of American children living in urban areas.
However, our review points to several major methodological limitations and critical knowledge gaps in the extant
literature, including: 1) the lack of studies with longitudinal brain and behavior assessments; 2) relatively small
samples from localized geographical areas; 3) little to no information on long-term cumulative and/or differential
timing of exposure across development; and 4) remaining questions regarding the neurotoxicity of PM2.5
exposure on critical neurobehavioral processes that continue to mature across adolescence. Although animal
neurotoxicology studies have highlighted the importance of sex, there is only limited epidemiologic evidence for
sex difference in PM2.5 neurotoxicity in children. Moreover, brain development is also shaped by family- and
community-level social factors, but whether and how air pollution neurotoxicity interacts with the social context
remains unclear. This application will leverage the nationwide longitudinal
Development (ABCD) study of 9- and 10-year-olds (N=11,873)
Adolescent Brain Cognitive
to examine prenatal and childhood air pollution
exposure effects on neurobehavioral development in boys and girls across 21 U.S. cities. ABCD outcome
measures are anchored on the transition to early adolescence because neuromaturation continues from
childhood through early adulthood, making such developmental transition periods potentially more vulnerable to
environmental insults. Our primary exposure of interest is PM2.5, but advances in well-validated spatiotemporal
modeling tools will also allow us to explore neurotoxicity of PM composition and other gaseous pollutants (i.e.
NO2, O3). Given the reconstructed exposure histories from gestation to childhood to early-adolescence, we will:
(a) determine long-term cumulative exposure effects; and (b) examine differential exposure effects across
sensitive time windows to better define PM2.5 neurotoxicity on executive functioning (EF) and emotional
behaviors from ages 9 to 12 years-old (Aim 1); and also understand how the resulting neurotoxicity influences
structural and functional brain development, including brain morphology, white matter microstructure, brain
activity at rest and during EF and emotion-focused tasks, and functional connectivity of large-scale networks
(Aim 2). In Aim 3, we will evaluate if children are more susceptible to PM2.5 effects based on: a) sex and SES;
and b) family- and neighborhood-level contextual risk and protective factors. This application will advance our
understanding of air pollution neurotoxicity on adolescent brains, as well as how exposure effects may vary
across sensitive time windows of development and/or differ by individual susceptibility. The resulting new
knowledge will contribute to sciences-based air pollution regulations to protect public health, but also inform the
development of preventions and interventions targeting sensitive time-windows and vulnerable populations.
项目摘要
细颗粒物(空气动力学直径2.5μm;pm2.5)是一种新的、普遍存在的环境
神经毒素影响数百万生活在城市地区的美国儿童的神经行为发育。
然而,我们的审查指出了现有的几个主要的方法限制和关键的知识差距。
文献,包括:1)缺乏对大脑和行为进行纵向评估的研究;2)相对较少
来自本地地理区域的样本;3)很少或根本没有关于长期累积和/或差异的信息
发育过程中暴露的时间;以及4)关于PM2.5神经毒性的剩余问题
暴露在关键的神经行为过程中,这些过程在青春期继续成熟。虽然是动物
神经毒理学研究已经强调了性行为的重要性,只有有限的流行病学证据表明
儿童PM2.5神经毒性的性别差异。此外,大脑的发育也是由家庭和
社区层面的社会因素,但空气污染神经毒性是否以及如何与社会背景相互作用
目前仍不清楚。此应用程序将利用全国纵向
9岁和10岁儿童发育(ABCD)研究(N=11,873)
青春期大脑认知
检查产前和儿童的空气污染
暴露对美国21个城市男孩和女孩神经行为发育的影响。Y01D1D01D1D1D1D1D1A1A1A9结果
措施的基础是过渡到青春期早期,因为神经成熟从
从童年到成年早期,使得这样的发育过渡期可能更容易受到
对环境的侮辱。我们主要关注的是PM2.5,但在经过充分验证的时空方面的进展
建模工具还将使我们能够探索PM成分和其他气态污染物(即
NO2,O3.)。考虑到重建的从怀孕到儿童再到青春期早期的暴露历史,我们将:
(A)确定长期累积暴露影响;和(B)审查不同的暴露影响
更好地确定PM2.5对执行功能(EF)和情绪的神经毒性的敏感时间窗口
从9岁到12岁的行为(目标1);并了解由此产生的神经毒性如何影响
结构和功能脑发育,包括脑形态,脑白质微结构,脑
静息和EF期间的活动以及情绪集中任务,以及大规模网络的功能连接
(目标2)。在目标3中,我们将评估儿童是否更容易受到PM2.5影响:a)性别和社会经济状况;
以及b)家庭和邻里层面的背景风险和保护因素。此应用程序将推进我们的
了解空气污染对青少年大脑的神经毒性,以及暴露的影响可能如何变化
在发展的敏感时间窗口和/或因个体敏感性不同而不同。由此产生的新
知识将有助于制定以科学为基础的空气污染法规,以保护公众健康,但也将为
制定针对敏感时间窗口和弱势群体的预防和干预措施。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Megan Marie Herting其他文献
Megan Marie Herting的其他文献
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{{ truncateString('Megan Marie Herting', 18)}}的其他基金
The role of air pollution in emotional neurodevelopment and risk for psychiatric disorders
空气污染在情绪神经发育和精神疾病风险中的作用
- 批准号:
10445289 - 财政年份:2020
- 资助金额:
$ 63.6万 - 项目类别:
Urban air pollution and neurobehavioral trajectories in the ABCD study
ABCD 研究中的城市空气污染和神经行为轨迹
- 批准号:
10445343 - 财政年份:2020
- 资助金额:
$ 63.6万 - 项目类别:
Urban air pollution and neurobehavioral trajectories in the ABCD study
ABCD 研究中的城市空气污染和神经行为轨迹
- 批准号:
10653053 - 财政年份:2020
- 资助金额:
$ 63.6万 - 项目类别:
The role of air pollution in emotional neurodevelopment and risk for psychiatric disorders
空气污染在情绪神经发育和精神疾病风险中的作用
- 批准号:
10267189 - 财政年份:2020
- 资助金额:
$ 63.6万 - 项目类别:
The role of air pollution in emotional neurodevelopment and risk for psychiatric disorders
空气污染在情绪神经发育和精神疾病风险中的作用
- 批准号:
10653023 - 财政年份:2020
- 资助金额:
$ 63.6万 - 项目类别:
Urban air pollution and neurobehavioral trajectories in the ABCD study
ABCD 研究中的城市空气污染和神经行为轨迹
- 批准号:
10045490 - 财政年份:2020
- 资助金额:
$ 63.6万 - 项目类别:
The Role of Androgens in Amygdala Subnuclei Development Across Human Adolescence
雄激素在人类青春期杏仁核亚核发育中的作用
- 批准号:
9388088 - 财政年份:2017
- 资助金额:
$ 63.6万 - 项目类别:
The Influence of Fetal Testosterone on Emotional Processing, Amydala Neurocircuitry, and Risk for Affective Disorders in Childhood
胎儿睾酮对情绪处理、杏仁核神经回路和儿童时期情感障碍风险的影响
- 批准号:
9330938 - 财政年份:2016
- 资助金额:
$ 63.6万 - 项目类别:
8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA
8/21 ABCD-美国联盟:CHLA 研究项目现场
- 批准号:
10157918 - 财政年份:2015
- 资助金额:
$ 63.6万 - 项目类别:
8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA
8/21 ABCD-美国联盟:CHLA 研究项目现场
- 批准号:
9980721 - 财政年份:2015
- 资助金额:
$ 63.6万 - 项目类别:
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