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Urban air pollution and neurobehavioral trajectories in the ABCD study

ABCD 研究中的城市空气污染和神经行为轨迹

基本信息

批准号：
10256619
负责人：
Megan Marie Herting
金额：
$ 63.6万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-09 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10256619
关键词：
10 year old 12 year old Address Adolescence Adolescent Adult Adverse effects Affect Age Air Air Pollutants Air Pollution American Animals Area Behavior assessment Behavioral Brain Caliber Carbon Charge Child Childhood Cities Cognitive Communities Conflict (Psychology)Corpus striatum structure Crime Data Development Developmental Course Dorsal Emotional Emotions Enrollment Environmental Risk Factor Epidemiology Exposure to Family Geographic Locations Geography Health Heterogeneity Human Hybrids Individual Intervention Knowledge Life Literature Longitudinal Studies Magnetic Resonance Imaging Maps Methodology Modeling Morphology Neighborhoods Neurocognitive Neuroepidemiology Neurotoxins Nitrates Nitrogen Dioxide Optimum Populations Outcome Outcome Measure Ozone Policies Population Population Characteristics Population Heterogeneity Predisposition Prefrontal Cortex Pregnancy Prevention Prevention program Process Public Health Recording of previous events Regulation Resolution Rest Risk Factors Role Sampling Science Sex Differences Social Environment Socioeconomic Status Structure Sulfate Surface Time Violence Visit Vulnerable Populations Youth base behavior test boys brain behavior brain morphology cognitive control cognitive development cohort design developmental neurotoxicity disadvantaged background early adolescence early childhood emerging adult emotional behavior executive function fine particles follow-up girls gray matter improved interest intervention program multi-ethnic multimodality neurobehavioral neuroimaging neurotoxic neurotoxicity neurotoxicology novel parental involvement particle pollutant preadolescence prenatal prospective protective factors recruit resilience sex sexual dimorphism social social factors sociodemographics spatiotemporal tool urban area white matter

项目摘要

Project Summary Fine particulate matter (aerodynamic diameter<2.5 μm; PM2.5) is a novel and ubiquitous environmental neurotoxin affecting neurobehavioral development of millions of American children living in urban areas. However, our review points to several major methodological limitations and critical knowledge gaps in the extant literature, including: 1) the lack of studies with longitudinal brain and behavior assessments; 2) relatively small samples from localized geographical areas; 3) little to no information on long-term cumulative and/or differential timing of exposure across development; and 4) remaining questions regarding the neurotoxicity of PM2.5 exposure on critical neurobehavioral processes that continue to mature across adolescence. Although animal neurotoxicology studies have highlighted the importance of sex, there is only limited epidemiologic evidence for sex difference in PM2.5 neurotoxicity in children. Moreover, brain development is also shaped by family- and community-level social factors, but whether and how air pollution neurotoxicity interacts with the social context remains unclear. This application will leverage the nationwide longitudinal Development (ABCD) study of 9- and 10-year-olds (N=11,873) Adolescent Brain Cognitive to examine prenatal and childhood air pollution exposure effects on neurobehavioral development in boys and girls across 21 U.S. cities. ABCD outcome measures are anchored on the transition to early adolescence because neuromaturation continues from childhood through early adulthood, making such developmental transition periods potentially more vulnerable to environmental insults. Our primary exposure of interest is PM2.5, but advances in well-validated spatiotemporal modeling tools will also allow us to explore neurotoxicity of PM composition and other gaseous pollutants (i.e. NO2, O3). Given the reconstructed exposure histories from gestation to childhood to early-adolescence, we will: (a) determine long-term cumulative exposure effects; and (b) examine differential exposure effects across sensitive time windows to better define PM2.5 neurotoxicity on executive functioning (EF) and emotional behaviors from ages 9 to 12 years-old (Aim 1); and also understand how the resulting neurotoxicity influences structural and functional brain development, including brain morphology, white matter microstructure, brain activity at rest and during EF and emotion-focused tasks, and functional connectivity of large-scale networks (Aim 2). In Aim 3, we will evaluate if children are more susceptible to PM2.5 effects based on: a) sex and SES; and b) family- and neighborhood-level contextual risk and protective factors. This application will advance our understanding of air pollution neurotoxicity on adolescent brains, as well as how exposure effects may vary across sensitive time windows of development and/or differ by individual susceptibility. The resulting new knowledge will contribute to sciences-based air pollution regulations to protect public health, but also inform the development of preventions and interventions targeting sensitive time-windows and vulnerable populations.

项目总结