8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA

8/21 ABCD-美国联盟：CHLA 研究项目现场

• 批准号: 10157918
• 负责人: Megan Marie Herting
• 金额: $ 18.02万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10157918
• 关键词: 10 year old; Academic achievement; Acute; Address; Administrative Supplement; Adolescence; Adolescent; Adolescent Development; Adopted; Affect; Age; Alcohol or Other Drugs use; Area; Behavioral; Biological; Biological Assay; Brain; COVID-19; COVID-19 pandemic; Cellular Phone; Censuses; Cessation of life; Characteristics; Child; Child Health; Chronic stress; Cognition; Collection; Communities; Coronavirus; County; Data; Data Analyses; Data Collection; Development; Dimensions; Disasters; Economics; Employment; Enrollment; Environment; Event; Exposure to; Family; Funding; Home environment; Incidence; Income; Individual; Infection; Infrastructure; Intervention; Lead; Link; Longitudinal Studies; Measurement; Measures; Mental Health; Moods; Movement; National Institute of Drug Abuse; Nature; Neighborhoods; Neuropsychological Tests; Occupations; Outcome; Parents; Participant; Patient Self-Report; Pattern; Policies; Population Density; Prevalence; Prevention; Protocols documentation; Questionnaires; Reporting; Research; Research Project Grants; Resource Informatics; Risk; Risk Factors; Schools; Services; Shock; Site; Social Distance; Social Functioning; Socioeconomic Status; Source; Stress; Structure; Support System; Unemployment; United States; Variant; Viral; Wages; Work; Youth; base; cognitive development; cohort; experience; infrastructure development; lower income families; mortality; neuroimaging; pandemic disease; payment; physical conditioning; protective factors; resilience; response; young adult

The Adolescent Brain Cognitive Development (ABCD) study is the largest long-term study of child health and brain development in the US, consisting of a Coordinating Center, a Data Analysis and Informatics Resource Center, and 21 research sites. The ABCD Study has enrolled a diverse cohort of 11,878 9-10-year-olds and will continue to track their biological and behavioral development through adolescence into young adulthood. All participants receive neuroimaging, neuropsychological testing, bioassays, and detailed youth and parent assessments of substance use, mental health, physical health, and culture and environment. In March 2020, when our participants were ages 11-13, the world became substantially affected by the COVID-19 pandemic, leading to an upheaval in the economy and the lives of almost every family. Most U.S. schools closed to reduce viral spread. Many parents incurred changes in work (e.g., working-from-home, longer shifts, reduced wages, job loss). Some services and support systems became disrupted. And, the number of confirmed cases and deaths have continued to surge. The massive multifaceted impact of this unprecedented event has the potential to affect today’s children for decades to come. Here, we propose to leverage ABCD’s infrastructure, cohort, and existing protocol to rapidly characterize the impacts of the COVID-19 pandemic on each child in the study. In this proposal, we will capitalize on funded (NSF; PI Tapert) and pending supplements to administer queries to all ABCD participants and their parents about the impact of the pandemic on their lives (family level impact) by also incorporating publicly and privately available measures of community-level COVID-19 impacts. For participants’ neighborhoods (e.g., census tract, county, state), we will geocode measures of incidence, spatial distancing, changes in (un)employment, and timing of implementation of state and/or local policies on mitigation practices. By collecting this situational information at the family and community levels as soon as possible, we can use existing ABCD data to examine perturbations in developmental trajectories of brain functioning, cognition, substance use, academic achievement, social functioning, and physical and mental health. Specifically, we will (1) focus on characterizing the nature and variability of the community and regional impact of COVID-19, based on geocoding of ABCD participants’ neighborhoods (i.e., current home address) and (2) determine how community-level and family-level impacts of COVID-19 differentially influence stress, cognition, and mental health during and after the pandemic. We will analyze (1) the interactions between family- and community-specific impacts on ABCD participants’ immediate stress and mental health during the pandemic, (2) the extent to which such potential impacts are associated with each other, and (3) how both community and family factors (e.g., SES, neighborhood characteristics) may serve as protective factors. This unprecedented crisis provides an opportunity to exploit ABCD’s infrastructure and scientific rigor to discern critical dimensions of development not previously envisioned.

青少年大脑认知发展（ABCD）研究是关于儿童健康和认知发展的最大规模的长期研究 美国大脑发育中心，由协调中心、数据分析和信息学资源组成 中心和 21 个研究点。 ABCD 研究招募了 11,878 名 9-10 岁的不同人群 将继续跟踪他们从青春期到成年早期的生物和行为发展。 所有参与者均接受神经影像学、神经心理学测试、生物测定以及详细的青少年和家长信息 对物质使用、心理健康、身体健康以及文化和环境的评估。 2020年3月， 当我们的参与者年龄为 11-13 岁时，世界受到了 COVID-19 大流行的严重影响， 导致经济和几乎每个家庭的生活发生剧变。大多数美国学校停课 减少病毒传播。许多父母的工作发生了变化（例如，在家工作、轮班时间更长、工作时间减少） 工资、失业）。一些服务和支持系统受到干扰。并且，确诊病例数 死亡人数持续激增。这一史无前例的事件产生了巨大的多方面影响 可能会在未来几十年影响今天的儿童。在这里，我们建议利用 ABCD 的基础设施， 队列和现有方案，以快速描述 COVID-19 大流行对每个儿童的影响 研究。在此提案中，我们将利用资助的（NSF；PI Tapert）和待决的补充 向所有 ABCD 参与者及其父母询问流感大流行对其生活的影响 （家庭层面的影响）还纳入社区层面的公开和私人可用措施 COVID-19 的影响。对于参与者的社区（例如人口普查区、县、州），我们将对 发生率、空间距离、就业（失业）变化以及国家实施时间的衡量标准 和/或有关缓解措施的地方政策。通过在家里收集这些情况信息 尽快在社区层面，我们可以使用现有的 ABCD 数据来检查扰动 大脑功能、认知、物质使用、学业成就、社交的发展轨迹 功能以及身心健康。具体来说，我们将（1）专注于描述自然和 基于 ABCD 参与者的地理编码，了解 COVID-19 的社区和区域影响的变化 社区（即当前家庭住址）和（2）确定社区层面和家庭层面的影响 COVID-19 在大流行期间和之后对压力、认知和心理健康产生不同的影响。我们将 分析 (1) 家庭和社区特定影响对 ABCD 参与者的直接影响之间的相互作用 大流行期间的压力和心理健康，(2) 此类潜在影响的相关程度 彼此之间的关系，以及 (3) 社区和家庭因素（例如社会经济地位、邻里特征）如何影响 起到保护因素的作用。这场前所未有的危机提供了利用 ABCD 基础设施的机会 以及科学的严谨性来辨别以前未曾预见到的发展的关键维度。