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The role of air pollution in emotional neurodevelopment and risk for psychiatric disorders

空气污染在情绪神经发育和精神疾病风险中的作用

基本信息

批准号：
10267189
负责人：
Megan Marie Herting
金额：
$ 52.48万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-21 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10267189
关键词：
10 year old Address Adolescence Adolescent Adult Affect Affective Age Age of Onset Aggressive behavior Air Pollution Amygdaloid structure Anterior Anxiety Attention deficit hyperactivity disorder Axon Behavior Behavioral Biological Blood Brain Brain region Child Childhood Chronic Cities Clinical Markers Data Dendrites Development Diagnosis Diagnostic Diagnostic and Statistical Manual of Mental Disorders Dimensions Disease Early Intervention Emotional Emotions Enrollment Environmental Health Environmental Impact Epidemiology Exposure to Functional Magnetic Resonance Imaging Geography Health Policy Human Individual Inhalation Toxicology Intervention Knowledge Link Literature Long-Term Effects Longitudinal Studies Measures Mediation Mental Depression Mental Health Mental disorders Methodology Morphology Neurites Neurotoxins Nitrogen Dioxide Ozone Particulate Matter Patient Self-Report Policies Prevention Prevention program Problem behavior Psychopathology Quality of life Regulation Research Risk Risk Factors Role Sampling Signal Transduction Structure Testing Time Toxicology Visit ambient air pollution anxiety symptoms base behavioral impairment cognitive development cohort density depressive symptoms design early adolescence emotional stimulus fine particles follow-up gray matter health data improved interest modifiable risk multi-ethnic multimodality neural circuit neurodevelopment neuroimaging neuroimaging marker neurophysiology neurotoxic novel pollutant postnatal pre-clinical prenatal relating to nervous system societal costs sociodemographics treatment program urban area white matter

项目摘要

Project Abstract Outdoor air pollution, including fine particulate matter (PM2.5; and its constituents) and nitrogen dioxide (NO2), is ubiquitous in urban areas and is a neurotoxicant. Emerging toxicological and epidemiological evidence suggests that air pollution may contribute to increases in emotional behavioral problems and is linked to various mental health disorders in children, adolescents, and adults. These recent findings have elucidated the need to: 1) examine long-term effects of prenatal and childhood exposure; 2) identify pre-clinical neuroimaging biomarkers of neurotoxicological effects in neural circuitry implicated in mental health risk; and 3) investigate these effects in late-childhood and adolescence, as it is an opportune time to identify and intervene for those at risk for psychiatric disorders. We propose the first longitudinal study to examine how prenatal and childhood air pollution exposure impacts corticolimbic circuitry involved in emotion processing and regulation, and the onset of internalizing and externalizing psychopathology during the transition from late-childhood to early adolescence. Our hypothesis is that prenatal and childhood air pollution exposure contribute to increased risk for mental health disorders during adolescence through alterations in corticolimbic neural circuitry and emotional development. To test our hypothesis, the proposed project will create lifetime residential air pollution exposure estimates and leverage comprehensive neuroimaging of corticolimbic neural circuitry, emotion, and mental health data, from a multi-ethnic and geographically diverse cohort of 9- to 10-year-old children (N=11,873) enrolled in the nationwide longitudinal Adolescent Brain Cognitive Development (ABCD) study. Using multi-modal neuroimaging, we will elucidate the effects of prenatal and childhood air pollution exposure on changes in the structure (Aim 1) and function (Aim 2) of corticolimbic circuitry underlying emotional processing and regulation from late-childhood to early adolescence. In Aim 3, we will examine how prenatal and childhood air pollution exposure influences the development of emotional problems and subsequent risk for mental health disorders by using both: a) dimensional scales and b) mental health diagnostic criteria (based on Diagnostic and Statistical Manual of Mental Disorders). As an exploratory sub-aim, we will also examine a potential mediation of corticolimbic alterations at 9-10 yrs in the link between air pollution exposure during development and subsequent risk for internalizing and externalizing psychopathology at ages 11-12 yrs. This study is primarily focused on long-term prenatal and childhoodPM2.5 and NO2 exposure; however, we also plan to explore differential timing effects of these exposures as well as the potential neurotoxic effects of other ambient pollutants (i.e. ozone, PM components). The large, sociodemographic and geographic diverse sample of children from ABCD are at an opportune age to evaluate pre-clinical markers of psychopathology. This provides great promise for more robust and generalizable findings that have the potential to impact policy as well as identify early neuroimaging biomarkers as targets for early intervention.

项目摘要