Basic Research Support for the CCR

CCR的基础研究支持

• 批准号: 10262741
• 负责人: thomas a misteli
• 金额: $ 48.86万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10262741
• 关键词: Acquired Immunodeficiency Syndrome; Affect; Area; Basic Science; Biochemical; Biochemistry; Biology; Biomedical Research; Biophysics; Cellular biology; Chemicals; Chromosomes; Crystallography; Development; Diagnosis; Diagnostic; Disease; Disease Progression; Disease susceptibility; Evolution; Genetic; HIV; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Human Resources; Immune response; Immunologics; Immunotherapy; Inflammation; Informatics; Laboratories; Laboratory Research; Malignant Neoplasms; Molecular; Molecular Genetics; Molecular Profiling; Molecular Target; Molecular Virology; Mus; NCI Center for Cancer Research; Nucleic Acids; Organism; Peptides; Process; Proteins; RNA; Regulation; Renal carcinoma; Research; Research Support; Resistance; Retrovirology; Structure; Susceptibility Gene; System; T-Lymphocyte; Technical Expertise; Techniques; Transplantation; Travel; Urologic Oncology; Vaccines; Virus; adaptive immunity; cancer genetics; cancer therapy; clinical investigation; immune reconstitution; in vivo; macromolecule; mouse genetics; pre-clinical; programs; small molecule; structural biology; tool; tumor; tumorigenesis; virology; virus host interaction

The Basic Science Program (BSP) provides scientific and technical expertise to NCI's Center for Cancer Research (CCR) related to cancer and other diseases, and to develop cutting-edge tools to accelerate progress. Areas of focus include cancer, retrovirology, basic biology, structural biology, informatics, cellular mechanisms, and the genetic factors that influence disease susceptibility and progression. There are 13 CCR research programs supported by the BSP: 1) Basic Research Laboratory - research on the cellular, molecular, genetic, biochemical, and immunological mechanisms affecting the progression, diagnosis, and treatment of cancer; 2) Cancer and Inflammation Program - studies focus on how innate resistance and adaptive immunity participate in oncogenesis and tumor surveillance; 3) Chemical Biology Laboratory - discovery of new small molecules, peptides, macromolecules, arrays and materials that impact cancer and AIDS diagnostics and treatment; 4) RNA Biology Laboratory - uses a variety of organisms to investigate chromosome dynamics and regulation; 5) HIV Dynamics and Replication Program - studies in structural biology, biochemistry, virology, virus-host interaction, evolution, and in vivo virus biology to better understand mechanisms of retroviral replication; 6) Macromolecular Crystallography Laboratory - investigates systems and techniques relevant to macromolecular crystallography and its applications; 7) Molecular Targets Program - an interdisciplinary, collaborative, team-oriented approach to identifying and validating potential cancer-pertinent targets; 8) Mouse Cancer Genetics Program - uses molecular mouse genetics as a primary tool to better understand the fundamental processes underlying mammalian development and disease; 9) Structural Biophysics Laboratory - solution structural biology and biophysics aimed at understanding and regulating the mechanism of action of proteins and nucleic acids; 10) Urologic Oncology Branch - discovery and characterization of renal carcinoma susceptibility genes; 11) Genetics Branch - molecular profile of a given biospecimen; 12) Vaccine Branch - elucidate basic mechanisms of immune response and molecular virology and 13) Experimental Transplantation and Immunotherapy Branch - basic, preclinical and clinical investigations in the areas of immunotherapy, immune reconstitution, T cell biology, hematopoiesis, and hematopoietic stem cell transplantation.

基础科学计划 (BSP) 向 NCI 癌症研究中心 (CCR) 提供与癌症和其他疾病相关的科学和技术专业知识，并开发尖端工具以加速进展。重点领域包括癌症、逆转录病毒学、基础生物学、结构生物学、信息学、细胞机制以及影响疾病易感性和进展的遗传因素。 BSP 支持 13 个 CCR 研究项目： 1) 基础研究实验室 - 研究影响癌症进展、诊断和治疗的细胞、分子、遗传、生化和免疫机制； 2）癌症与炎症项目——研究重点是先天抵抗和适应性免疫如何参与肿瘤发生和肿瘤监测； 3) 化学生物学实验室——发现影响癌症和艾滋病诊断和治疗的新小分子、肽、大分子、阵列和材料； 4）RNA生物学实验室——利用多种生物体研究染色体动力学和调控； 5) HIV动力学和复制计划——结构生物学、生物化学、病毒学、病毒-宿主相互作用、进化和体内病毒生物学研究，以更好地了解逆转录病毒复制机制； 6）高分子晶体学实验室——研究与高分子晶体学及其应用相关的系统和技术； 7) 分子靶标计划——一种跨学科、协作、以团队为导向的方法，用于识别和验证潜在的癌症相关靶标； 8) 小鼠癌症遗传学计划——利用小鼠分子遗传学作为主要工具，更好地了解哺乳动物发育和疾病的基本过程； 9）结构生物物理实验室——解决结构生物学和生物物理学，旨在理解和调节蛋白质和核酸的作用机制； 10) 泌尿肿瘤科——肾癌易感基因的发现和表征； 11) 遗传学分支——给定生物样本的分子谱； 12）疫苗分支 - 阐明免疫反应和分子病毒学的基本机制。 13）实验移植和免疫治疗分支 - 免疫治疗、免疫重建、T细胞生物学、造血和造血干细胞移植领域的基础、临床前和临床研究。