Basic Research Support for the CCR

基础研究计划（BRP）为NCI的癌症研究中心（CCR）提供科学和技术专业知识，范围从癌症和人类免疫缺陷病毒(HIV)/获得性免疫缺陷综合征（AIDS），到癌症、传染病和自身免疫性疾病的基本细胞过程。BSP支持的CCR研究项目有10个：1)基础研究实验室-研究影响癌症进展、诊断和治疗的细胞、分子、遗传、生化和免疫学机制2)癌症和炎症项目-研究重点是先天抵抗和适应性免疫如何参与肿瘤发生和肿瘤监测3)化学生物学实验室-发现新的小分子、多肽、大分子、基因调控和染色体生物学实验室-使用各种生物体来研究染色体动力学和调控5)HIV动力学和复制计划-研究结构生物学，生物化学，病毒学，病毒-宿主相互作用，进化，和体内病毒生物学，以更好地了解逆转录病毒复制的机制6)大分子晶体学实验室-研究与大分子晶体学及其应用相关的系统和技术7)分子靶标实验室-一个跨学科，合作，以团队为导向的方法识别和验证潜在的癌症相关靶点8)小鼠癌症遗传学项目-使用分子小鼠遗传学作为主要工具，以更好地了解哺乳动物发育和疾病的基本过程9)结构生物物理实验室-解决结构生物学和生物物理学，旨在理解和调节蛋白质和核酸的作用机制10)泌尿肿瘤学分支-发现和表征肾癌易感基因

The Basic Research Program (BRP) provides scientific and technical expertise to NCI's Center for Cancer Research (CCR) in areas ranging from cancer and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), to the basic cellular processes underlying cancer, infectious diseases, and autoimmune disorders. There are 10 CCR research programs supported by the BSP: 1) Basic Research Laboratory - research on the cellular, molecular, genetic, biochemical, and immunological mechanisms affecting the progression, diagnosis, and treatment of cancer 2) Cancer and Inflammation Program - studies focus on how innate resistance and adaptive immunity participate in oncogenesis and tumor surveillance 3) Chemical Biology Laboratory - discovery of new small molecules, peptides, macromolecules, arrays and materials that impact cancer and AIDS diagnostics and treatment 4) Gene Regulation and Chromosome Biology Laboratory - uses a variety of organisms to investigate chromosome dynamics and regulation 5) HIV Dynamics and Replication Program - studies in structural biology, biochemistry, virology, virus-host interaction, evolution, and in vivo virus biology to better understand mechanisms of retroviral replication 6) Macromolecular Crystallography Laboratory - investigates systems and techniques relevant to macromolecular crystallography and its applications 7) Molecular Targets Laboratory - an interdisciplinary, collaborative, team-oriented approach to identifying and validating potential cancer-pertinent targets 8) Mouse Cancer Genetics Program - uses molecular mouse genetics as a primary tool to better understand the fundamental processes underlying mammalian development and disease 9) Structural Biophysics Laboratory - solution structural biology and biophysics aimed at understanding and regulating the mechanism of action of proteins and nucleic acids 10) Urologic Oncology Branch - discovery and characterization of renal carcinoma susceptibility genes