Basic Research Support for the CCR

CCR的基础研究支持

• 批准号: 9344156
• 负责人: thomas a misteli
• 金额: $ 91.76万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9344156
• 关键词: Acquired Immunodeficiency Syndrome; Affect; Area; Autoimmune Diseases; Basic Science; Biochemical; Biochemistry; Biology; Biomedical Research; Biophysics; Cell physiology; Chemicals; Chromosomes; Communicable Diseases; Crystallography; Development; Diagnosis; Diagnostic; Disease; Evolution; Gene Expression Regulation; Genetic; Genetic Programming; HIV; Human Resources; Inflammation; Laboratories; Laboratory Research; Malignant Neoplasms; Molecular; Molecular Genetics; Molecular Target; Mus; NCI Center for Cancer Research; Nucleic Acids; Organism; Peptides; Process; Proteins; Qualifying; Regulation; Renal carcinoma; Research; Research Support; Resistance; Susceptibility Gene; System; Technical Expertise; Techniques; Travel; Urologic Oncology; Virus; adaptive immunity; anticancer research; cancer genetics; cancer therapy; in vivo; macromolecule; programs; small molecule; structural biology; tool; tumor; tumorigenesis; virology; virus host interaction

The Basic Research Program (BRP) provides scientific and technical expertise to NCI's Center for Cancer Research (CCR) in areas ranging from cancer and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), to the basic cellular processes underlying cancer, infectious diseases, and autoimmune disorders. There are 10 CCR research programs supported by the BSP: 1) Basic Research Laboratory - research on the cellular, molecular, genetic, biochemical, and immunological mechanisms affecting the progression, diagnosis, and treatment of cancer 2) Cancer and Inflammation Program - studies focus on how innate resistance and adaptive immunity participate in oncogenesis and tumor surveillance 3) Chemical Biology Laboratory - discovery of new small molecules, peptides, macromolecules, arrays and materials that impact cancer and AIDS diagnostics and treatment 4) Gene Regulation and Chromosome Biology Laboratory - uses a variety of organisms to investigate chromosome dynamics and regulation 5) HIV Dynamics and Replication Program - studies in structural biology, biochemistry, virology, virus-host interaction, evolution, and in vivo virus biology to better understand mechanisms of retroviral replication 6) Macromolecular Crystallography Laboratory - investigates systems and techniques relevant to macromolecular crystallography and its applications 7) Molecular Targets Laboratory - an interdisciplinary, collaborative, team-oriented approach to identifying and validating potential cancer-pertinent targets 8) Mouse Cancer Genetics Program - uses molecular mouse genetics as a primary tool to better understand the fundamental processes underlying mammalian development and disease 9) Structural Biophysics Laboratory - solution structural biology and biophysics aimed at understanding and regulating the mechanism of action of proteins and nucleic acids 10) Urologic Oncology Branch - discovery and characterization of renal carcinoma susceptibility genes

基础研究计划（BRP）为NCI的癌症研究中心（CCR）提供科学和技术专业知识，范围从癌症和人类免疫缺陷病毒(HIV)/获得性免疫缺陷综合征（AIDS），到癌症、传染病和自身免疫性疾病的基本细胞过程。BSP支持的CCR研究项目有10个：1)基础研究实验室-研究影响癌症进展、诊断和治疗的细胞、分子、遗传、生化和免疫学机制2)癌症和炎症项目-研究重点是先天抵抗和适应性免疫如何参与肿瘤发生和肿瘤监测3)化学生物学实验室-发现新的小分子、多肽、大分子、基因调控和染色体生物学实验室-使用各种生物体来研究染色体动力学和调控5)HIV动力学和复制计划-研究结构生物学，生物化学，病毒学，病毒-宿主相互作用，进化，和体内病毒生物学，以更好地了解逆转录病毒复制的机制6)大分子晶体学实验室-研究与大分子晶体学及其应用相关的系统和技术7)分子靶标实验室-一个跨学科，合作，以团队为导向的方法识别和验证潜在的癌症相关靶点8)小鼠癌症遗传学项目-使用分子小鼠遗传学作为主要工具，以更好地了解哺乳动物发育和疾病的基本过程9)结构生物物理实验室-解决结构生物学和生物物理学，旨在理解和调节蛋白质和核酸的作用机制10)泌尿肿瘤学分支-发现和表征肾癌易感基因