Clinical Research Support for the CCR

CCR 的临床研究支持

• 批准号: 9344216
• 负责人: thomas a misteli
• 金额: $ 137.64万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9344216
• 关键词: Acquired Immunodeficiency Syndrome; Basic Science; Biological Assay; Biomedical Research; Cells; Cervical; Clinical; Clinical Investigator; Clinical Research; Clinical Services; Clinical Trials; Clinical Trials Design; Development; Disease; Disease Progression; Flow Cytometry; Generations; Goals; HIV; Human; Human Papilloma Virus Vaccine; Human Papillomavirus; Immune; Immune response; Immunologics; Immunology; Immunotoxin Therapy; Immunotoxins; Infection; Laboratories; Lesion; Lymphokines; Malignant Neoplasms; Measurement; Mission; Molecular Biology; Monitor; Mutation; NCI Center for Cancer Research; Natural History; Patients; Plasma; Play; Research; Research Support; Resistance development; Role; Sampling; Services; Testing; Transport Process; Vaccines; Viral; Viral Antigens; Viral Load result; Virus Diseases; anticancer research; base; bioprocess; cell mediated immune response; design; immune function; laboratory development; programs; response; sample collection; vaccine trial

Clinical Services Program (CSP) laboratories that currently support clinical research at the Center for Cancer Research (CCR) are highlighted below. The Clinical Support Laboratory provides clinical monitoring, flow cytometry, and lymphokine testing as well as clinically validated immunological assays in support of clinical trials and investigator-initiated basic research. The Human Papilloma Virus (HPV) Immunology Laboratory investigates cell-mediated immune responses to HPV antigens in natural history studies of HPV-induced cervical lesions and in HPV vaccine trials, with the goal of identifying putative correlates of immune protection against infection and disease progression. The Human Cancer Immunotoxin Therapy Assay Support and Development Laboratory provides dedicated support to CCR's Laboratory of Molecular Biology that includes immunotoxin cell-based neutralization assays and measurement of immunotoxin concentrations present in patient serum and plasma samples drawn during treatment. The AIDS Monitoring Laboratory performs sequential studies of immune function in patients with human immunodeficiency virus (HIV) disease during treatment with a variety of anti-viral and immunomodulatory agents. The BioProcessing Laboratory provides support to the CCR by providing expert services in specimen collection, packaging, transport, processing, storage, and distribution.

以下重点介绍了目前支持癌症研究中心（CCR）临床研究的临床服务计划（CSP）实验室。临床支持实验室提供临床监测、流式细胞术和淋巴因子检测以及经临床验证的免疫学检测，以支持临床试验和免疫学启动的基础研究。人乳头瘤病毒（HPV）免疫学实验室在HPV诱导的宫颈病变的自然史研究和HPV疫苗试验中研究对HPV抗原的细胞介导的免疫应答，目的是确定针对感染和疾病进展的免疫保护的推定相关性。人类癌症免疫毒素治疗检测支持和开发实验室为CCR的分子生物学实验室提供专门的支持，包括基于免疫毒素细胞的中和检测和治疗期间抽取的患者血清和血浆样本中存在的免疫毒素浓度的测量。艾滋病监测实验室对人类免疫缺陷病毒（艾滋病毒）疾病患者在接受各种抗病毒和免疫调节剂治疗期间的免疫功能进行连续研究。生物处理实验室通过在标本采集、包装、运输、处理、储存和分发方面提供专家服务，为CCR提供支持。