Clinical Research Support for the CCR

下面重点介绍目前支持癌症研究中心(CCR)临床研究的临床服务计划(CSP)实验室。临床支持实验室提供临床监测、流式细胞术和淋巴因子检测以及经临床验证的免疫学分析，以支持临床试验和研究人员发起的基础研究。人乳头瘤病毒(HPV)免疫学实验室在HPV诱导的宫颈病变的自然历史研究和HPV疫苗试验中研究对HPV抗原的细胞介导免疫反应，目的是确定针对感染的免疫保护和疾病进展的假定相关性。人类癌症免疫毒素治疗分析支持和开发实验室为CCR的分子生物学实验室提供专门的支持，该实验室包括基于免疫毒素细胞的中和分析，以及在治疗期间抽取的患者血清和血浆样本中免疫毒素浓度的测量。艾滋病监测实验室对人类免疫缺陷病毒(HIV)患者在接受各种抗病毒和免疫调节剂治疗期间的免疫功能进行连续研究。生物处理实验室通过在标本收集、包装、运输、加工、储存和分发方面提供专家服务，为CCR提供支持。

Clinical Services Program (CSP) laboratories that currently support clinical research at the Center for Cancer Research (CCR) are highlighted below. The Clinical Support Laboratory provides clinical monitoring, flow cytometry, and lymphokine testing as well as clinically validated immunological assays in support of clinical trials and investigator-initiated basic research. The Human Papilloma Virus (HPV) Immunology Laboratory investigates cell-mediated immune responses to HPV antigens in natural history studies of HPV-induced cervical lesions and in HPV vaccine trials, with the goal of identifying putative correlates of immune protection against infection and disease progression. The Human Cancer Immunotoxin Therapy Assay Support and Development Laboratory provides dedicated support to CCR's Laboratory of Molecular Biology that includes immunotoxin cell-based neutralization assays and measurement of immunotoxin concentrations present in patient serum and plasma samples drawn during treatment. The AIDS Monitoring Laboratory performs sequential studies of immune function in patients with human immunodeficiency virus (HIV) disease during treatment with a variety of anti-viral and immunomodulatory agents. The BioProcessing Laboratory provides support to the CCR by providing expert services in specimen collection, packaging, transport, processing, storage, and distribution.