Nuclear Architecture and Disease

核结构与疾病

• 批准号: 7291700
• 负责人: thomas a misteli
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7291700
• 关键词: Nuclear; Architecture; Disease

All genomes exist and function in the cell nucleus. Although we have made strides in decoding entire genomes, we only poorly understand how genomes function in intact cells. Our cell biological studies of genomes and the cell nucleus are aimed at uncovering fundamental concepts of genome organization and nuclear function in vivo and they are providing opportunities for applying these principles to human disease diagnosis, therapeutics and bioengineering.

所有的基因组都存在于细胞核中并发挥作用。虽然我们在解码整个基因组方面取得了长足的进步，但我们对基因组在完整细胞中的功能知之甚少。我们对基因组和细胞核的细胞生物学研究旨在揭示体内基因组组织和核功能的基本概念，并为将这些原则应用于人类疾病诊断，治疗和生物工程提供机会。