Occupational Exposure Assessment

职业暴露评估

• 批准号: 10263729
• 负责人: Melissa Friesen
• 金额: $ 23.28万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263729
• 关键词: Air; Aromatic Amines; Aromatic Polycyclic Hydrocarbons; Arsenic; Asbestos; Atrazine; Benzene; Biological Markers; Brain; Breast; Cadmium; Carcinogens; Case-Control Studies; Chemicals; Childhood Malignant Brain Tumor; Chlorinated Hydrocarbons; Chromium; Classification; Cohort Studies; Cross-Sectional Studies; Data; Development; Diesel Exhaust; Dose; Dust; Electromagnetic Fields; Ewings sarcoma; Exposure to; Formaldehyde; Gasoline; Germ cell tumor; Goals; Hormonal; Human; Immune; Kidney; Larynx; Lead; Lung; Lymphatic; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of urinary bladder; Measurement; Metals; Methodological Studies; Methods; Occupational; Occupational Exposure; Occupations; Pattern; Performance; Pesticides; Physical activity; Polychlorinated Biphenyls; Population Study; Procedures; Publishing; Questionnaires; Reporting; Solvents; Specificity; System; Techniques; Trichloroethylene; Validation; Woman; Wood material; base; case control; design; exhaust; genotoxicity; improved; leukemia; mathematical model; response

Assessment of occupational exposures is a crucial factor in evaluating dose-response relationships and most human population-based studies conducted by the Branch have an extensive exposure assessment component. Major assessment efforts in cohort studies have involved exposures to pesticides, benzene, polycyclic aromatic hydrocarbons, and diesel exhaust fumes, and to a broad range of exposures in a cohort study of women in Shanghai and shipyard workers. Cross-sectional studies are being conducted to study the effect of benzene, diesel exhaust, trichloroethylene, and atrazine on genotoxic, immune, and hormonal parameters. In the case-control design, jobs have been evaluated for a wide variety of exposures, including solvents (including chlorinated hydrocarbons, aromatic, and other solvents), metals (arsenic, chromium, cadmium, lead), electromagnetic fields, polychlorinated biphenyls, dusts (wood dust and other types) , asbestos, formaldehyde, physical activity, nitrosoamines, polycyclic aromatic hydrocarbons, gasoline and diesel exhausts, aromatic amines, and pesticides. These exposures have been evaluated in studies of cancer of the bladder, brain, breast, kidney, lung, larynx, and the lymphatic and hemtopoietic system, and of childhood brain cancer, germ cell tumor cancer, and leukemia Ewings sarcoma and possible associations with parental occupations. Methodologic studies are also conducted to improve exposure assessment techniques and to understand exposure patterns, such as peak exposures. A study has been conducted in Shanghai to evaluate assessments made from detailed occupational questionnaires with air measurements. A report describing the exposure assessment procedures for evaluating EMF exposures in a brain cancer case-control study has been published. Reports describing the occurrences of pesticides, polychlorinated biphenyls, chlorinated and aromatic solvents, wood dust, lead, cadmium, and nitrosoamines are being prepared. Detailed questionnair

职业照射评估是评估剂量-反应关系的一个关键因素，该处进行的大多数基于人群的研究都有广泛的照射评估内容。队列研究中的主要评估工作涉及杀虫剂、苯、多环芳烃和柴油废气的暴露，以及上海妇女和造船厂工人的队列研究中的广泛暴露。正在进行横断面研究，以研究苯、柴油废气、三氯乙烯和阿特拉津对基因毒性、免疫和激素参数的影响。在病例对照设计中，对各种暴露的工作进行了评估，包括溶剂（包括氯化烃、芳香烃和其他溶剂）、金属（砷、铬、镉、铅）、电磁场、多氯联苯、粉尘（木尘和其他类型）、石棉、甲醛、体育活动、亚硝胺、多环芳香烃、汽油和柴油废气、芳香胺和杀虫剂。这些暴露已在膀胱癌、脑癌、乳腺癌、肾癌、肺癌、喉癌、淋巴和造血系统癌、儿童脑癌、生殖细胞癌和白血病尤因斯肉瘤的研究中进行了评估，并可能与父母职业有关。还进行了方法学研究，以改进暴露评估技术并了解暴露模式，例如峰值暴露。在上海进行了一项研究，对带有空气测量的详细职业问卷进行评估。一份报告描述了评估脑癌病例对照研究中电磁场暴露的暴露评估程序。正在编写有关农药、多氯联苯、氯化和芳香溶剂、木屑、铅、镉和亚硝基胺发生情况的报告。详细的问卷